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内蒙古地区心血管病高危人群发生冠状动脉粥样硬化性心脏病的危险因素

苗宇 闫涛 张子英 郭淑怡 王靖宇 闫金利 许蕾 王雅 张春发 钟武志 张楠 张星光

苗宇, 闫涛, 张子英, 郭淑怡, 王靖宇, 闫金利, 许蕾, 王雅, 张春发, 钟武志, 张楠, 张星光. 内蒙古地区心血管病高危人群发生冠状动脉粥样硬化性心脏病的危险因素[J]. 中华疾病控制杂志, 2024, 28(3): 310-315. doi: 10.16462/j.cnki.zhjbkz.2024.03.010
引用本文: 苗宇, 闫涛, 张子英, 郭淑怡, 王靖宇, 闫金利, 许蕾, 王雅, 张春发, 钟武志, 张楠, 张星光. 内蒙古地区心血管病高危人群发生冠状动脉粥样硬化性心脏病的危险因素[J]. 中华疾病控制杂志, 2024, 28(3): 310-315. doi: 10.16462/j.cnki.zhjbkz.2024.03.010
MIAO Yu, YAN Tao, ZHANG Ziying, GUO Shuyi, WANG Jingyu, YAN Jinli, XU Lei, WANG Ya, ZHANG Chunfa, ZHONG Wuzhi, ZHANG Nan, ZHANG Xingguang. Analysis of the risk factors of coronary heart disease in population at high cardiovascular risk in Inner Mongolia[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 310-315. doi: 10.16462/j.cnki.zhjbkz.2024.03.010
Citation: MIAO Yu, YAN Tao, ZHANG Ziying, GUO Shuyi, WANG Jingyu, YAN Jinli, XU Lei, WANG Ya, ZHANG Chunfa, ZHONG Wuzhi, ZHANG Nan, ZHANG Xingguang. Analysis of the risk factors of coronary heart disease in population at high cardiovascular risk in Inner Mongolia[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(3): 310-315. doi: 10.16462/j.cnki.zhjbkz.2024.03.010

内蒙古地区心血管病高危人群发生冠状动脉粥样硬化性心脏病的危险因素

doi: 10.16462/j.cnki.zhjbkz.2024.03.010
基金项目: 

国家自然科学基金 82160639

内蒙古自治区高等学校青年科技英才支持计划 NJYT22008

内蒙古医科大学心血管病分子流行病学及防治研究科技创新团队项目 YKD2022TD015

内蒙古医科大学学科建设项目 YKD2022XK012

详细信息
    通讯作者:

    张星光,E-mail:zxg311@126.com

    张楠,E-mail:17704713193@163.com

  • 中图分类号: R181.1;R714.252

Analysis of the risk factors of coronary heart disease in population at high cardiovascular risk in Inner Mongolia

Funds: 

National Natural Science Foundation of China 82160639

Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region NJYT22008

Scientific and Technological Innovation Team of Cardiovascular Molecular Epidemiology and Prevention Research, Inner Mongolia Medical University YKD2022TD015

Discipline Construction Project of Inner Mongolia Medical University YKD2022XK012

More Information
  • 摘要:   目的  探讨内蒙古地区心血管病高危人群冠状动脉粥样硬化性心脏病(coronary heart disease,CHD)发病的相关危险因素,为制定适合内蒙古地区CHD的防治策略提供科学依据。  方法  采用前瞻性队列研究方法,利用多阶段分层整群抽样方法。于2015年12月在内蒙古地区6个盟市开展调查,每年随访1次,直至2021年12月。基线调查包括一般情况、疾病史及治疗史、体格检查和实验室检测,随访调查包括心血管健康状况及临床终点事件收集。采用Cox回归模型分析影响CHD的发病因素。  结果  最终纳入37 726名研究对象,多因素Cox回归模型分析表明:增龄(HR>1.00, P < 0.001)、吸烟(HR=1.20, P < 0.001)、饮酒(HR=1.41, P < 0.001)、超重或肥胖(HR=1.19, P < 0.001)、高血压(HR=1.41, P < 0.001)、糖尿病(HR=1.22, P < 0.001)、血脂异常(HR=2.20, P < 0.001)为CHD发病的危险因素;高教育水平(HR < 1.00, P < 0.001)、非重体力劳动类型(HR < 1.00, P < 0.001)为CHD发病的保护因素。  结论  在内蒙古地区,增龄、吸烟、饮酒、血脂异常、高血压、糖尿病、超重或肥胖为CHD发病的危险因素,高教育水平、非重体力劳动为CHD发病的保护因素。
  • 图  1  不同年龄段人群CHD累计发病率曲线

    CHD, 冠状动脉粥样硬化性心脏病。

    Figure  1.  Cumulative incidence curves of CHD in different age groups

    CHD, coronary heart disease.

    表  1  研究对象的一般特征

    Table  1.   Baseline characteristics of the participants

    变量Variable 男性
    Male
    女性
    Female
    合计
    Total
    χ2值value P值value
    年龄组/岁Age group/years 89.85 <0.001
      35~<45 1 952(11.9) 1 951(9.2) 3 903(10.3)
      45~<55 4 815(29.3) 6 443(30.2) 11 258(29.8)
      55~<65 5 996(36.5) 8 352(39.2) 14 348(38.1)
      ≥65 3 652(22.3) 4 565(21.4) 8 217(21.8)
    民族Ethnicity 2.56 0.278
      汉族Han 14 756(89.9) 19 255(90.3) 34 011(90.2)
      蒙古族Mongol 1 463(8.9) 1 826(8.6) 3 289(8.7)
      其他民族Others 196(1.2) 230(1.1) 426(1.1)
    劳动类型Labor type 794.95 <0.001
      重体力劳动Heavy physical 7 800(47.5) 9 685(45.5) 17 485(46.3)
      失业、家务或退休Unemployment, housework or retirement 4 115(25.1) 7 828(36.7) 11 943(31.7)
      其他非重体力劳动Other non-heavy physical 4 500(27.4) 3 798(17.8) 8 298(22.0)
    血脂异常Dyslipidemia 2 079(12.7) 4 539(21.3) 6 618(17.5) 477.83 <0.001
    高血压Hypertension 13 764(83.9) 17 572(82.5) 31 336(83.1) 12.83 <0.001
    糖尿病Diabetes 4 279(26.1) 4 947(23.2) 9 226(24.5) 40.89 <0.001
    吸烟Smoking 8 102(49.4) 1 461(6.9) 9 563(25.3) 8 851.66 <0.001
    饮酒Drinking 4 277(26.1) 347(1.6) 4 624(12.3) 5 144.70 <0.001
    食用畜肉Eating meat 125.13 <0.001
      从不或几乎不Never or almost never 672(4.1) 1 263(5.9) 1 935(5.1)
      偶尔或每周<4次Occasionally or<4 times per week 8 276(50.4) 11 366(53.3) 19 642(52.1)
      每天或几乎每天Every day or almost every day 7 467(45.5) 8 682(40.8) 16 149(42.8)
    食用乳制品Eating dairy 10.15 0.006
      从不或几乎不Never or almost never 5 967(36.3) 7 928(37.2) 13 895(36.8)
      偶尔或每周<4次Occasionally or<4 times per week 7 200(43.9) 9 003(42.2) 16 203(43.0)
      每天或几乎每天Every day or almost every day 3 248(19.8) 4 380(20.6) 7 628(20.2)
    教育水平Educational level 1 546.24 <0.001
      小学及以下Primary school and below 4 591(28.0) 9 998(46.9) 14 598(38.7)
      中学及中专Secondary school 9 462(57.6) 9 717(45.6) 19 179(50.8)
      大学及以上University and above 2 362(14.4) 1 596(7.5) 3 958(10.5)
    家庭年收入/万元Annual household income/ten thousand yuan 250.49 <0.001
      <1 3 211(19.6) 5 248(24.6) 8 459(22.4)
      1~5 8 383(51.1) 11 143(52.3) 19 526(51.8)
      >5 4 821(29.3) 4 920(23.1) 9 741(25.8)
    体育锻炼Physical exercise 3.32 0.190
      从不或几乎不参加Never or almost never 9 680(58.9) 12 442(58.4) 22 122(58.7)
      偶尔或每周<5次Occasionally or<5 times per week 2 146(13.1) 2 921(13.7) 5 067(13.4)
      每天或几乎每天都锻炼Every day or almost every day 4 589(28.0) 5 948(27.9) 10 537(27.9)
    BMI 41.44 <0.001
      低或正常体重Low or normal 3 919(23.9) 5 709(26.8) 9 628(25.5)
      超重或肥胖Overweight or obesity 12 496(76.1) 15 602(73.6) 28 098(74.5)
    注:①以人数(占比/%)表示。
    Note: ① Number of people(proportion/%).
    下载: 导出CSV

    表  2  CHD发病影响因素的Cox回归模型分析

    Table  2.   Cox regression analysis of the influencing factors of CHD

    变量Variable 总人群Total Population 性别Gender
    男Male 女Female
    HR值value(95% CI) P值value HR值value(95% CI) P值value HR值value(95% CI) P值value
    性别Gender
      女Female 1.00
      男Male 1.16(1.03~1.31) 0.015
    年龄组/岁Age group/years
      35~<45 1.00 1.00 1.00
      45~<55 1.64(1.23~2.19) 0.001 1.84(1.21~2.80) 0.004 1.46(0.97~2.18) 0.068
      55~<65 2.91(2.20~3.85) < 0.001 3.25(2.17~4.86) < 0.001 2.59(1.75~3.83) < 0.001
      ≥65 3.95(2.96~5.27) < 0.001 4.40(2.90~6.68) < 0.001 3.52(2.36~5.26) < 0.001
    民族Ethnicity
      汉族Han 1.00 1.00 1.00
      蒙古族Mongol 1.11(0.92~1.34) 0.270 1.30(1.00~1.69) 0.048 0.97(0.74~1.26) 0.812
      其他民族Others 1.13(0.73~1.76) 0.581 0.73(0.32~1.62) 0.435 1.46(0.86~2.47) 0.166
    吸烟Smoking
      否No 1.00 1.00 1.00
      是Yes 1.20(1.05~1.36) 0.006 1.20(1.03~1.40) 0.022 1.24(0.98~1.56) 0.075
    饮酒Drinking
      否No 1.00 1.00 1.00
      是Yes 1.41(1.18~1.68) 0.001 1.43(1.18~1.72) <0.001 1.25(0.70~2.23) 0.445
    劳动类型Labor type
      重体力劳动Heavy physical 1.00 1.00 1.00
      失业、家务或退休Unemployment, housework or retirement 1.00(0.88~1.13) 0.945 1.04(0.86~1.26) 0.701 0.97(0.83~1.13) 0.671
      其他非重体力劳动Other non-heavy physical 0.64(0.52~0.78) < 0.001 0.71(0.54~0.92) 0.010 0.55(0.40~0.76) <0.001
    高血压患病Hypertension
      否No 1.00 1.00 1.00
      是Yes 1.41(1.27~1.57) < 0.001 1.34(1.15~1.57) <0.001 1.47(1.27~1.70) <0.001
    血脂异常患病Dyslipidemia
      否No 1.00 1.00 1.00
      是Yes 2.20(1.68~2.88) < 0.001 2.09(1.36~3.22) 0.001 2.28(1.61~3.23) < 0.001
    糖尿病患病Diabetes
      否No 1.00 1.00 1.00
      是Yes 1.22(1.06~1.41) 0.006 1.05(0.83~1.32) 0.679 1.34(1.12~1.60) 0.002
    BMI/(kg·m-2)
      低或正常体重Low or normal 1.00 1.00 1.00
      超重或肥胖Overweight or obesity. 1.19(1.06~1.35) 0.005 1.28(1.06~1.54) 0.010 1.12(0.95~1.32) 0.176
    家庭年收入/万元Annual household income/ten thousand yuan
      <1 1.00 1.00 1.00
      1~5 1.05(0.94~1.18) 0.379 1.07(0.89~1.29) 0.467 1.05(0.90~1.21) 0.553
      >5 0.99(0.83~1.18) 0.907 1.16(0.90~1.48) 0.255 0.85(0.67~1.08) 0.191
    教育水平Educational level
      小学及以下Primary school and below 1.00 1.00 1.00
      中学及中专Secondary school 0.82(0.73~0.92) 0.001 0.77(0.64~0.92) 0.004 0.88(0.75~1.03) 0.117
      大学及以上University and above 0.79(0.62~1.02) 0.069 0.77(0.56~1.05) 0.096 0.74(0.48~1.14) 0.168
    注: CHD, 冠状动脉粥样硬化性心脏病。
    Note: CHD, coronary heart disease.
    下载: 导出CSV
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出版历程
  • 收稿日期:  2023-10-08
  • 修回日期:  2024-01-06
  • 网络出版日期:  2024-04-08
  • 刊出日期:  2024-03-10

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