TNF-α rs1800629 polymorphisms in the genetic susceptibility to cervical cancer

DING Bo; SUN Wei; SHEN Yang; CAI Yun-lang; WANG Shi-zhi

doi:10.16462/j.cnki.zhjbkz.2019.07.021

Volume 23 Issue 7

Jul. 2019

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2019 > 23(7): 850-855

DING Bo, SUN Wei, SHEN Yang, CAI Yun-lang, WANG Shi-zhi. TNF-α rs1800629 polymorphisms in the genetic susceptibility to cervical cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(7): 850-855. doi: 10.16462/j.cnki.zhjbkz.2019.07.021

Citation:

DING Bo, SUN Wei, SHEN Yang, CAI Yun-lang, WANG Shi-zhi. TNF-α rs1800629 polymorphisms in the genetic susceptibility to cervical cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(7): 850-855. doi: 10.16462/j.cnki.zhjbkz.2019.07.021

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TNF-α rs1800629 polymorphisms in the genetic susceptibility to cervical cancer

doi: 10.16462/j.cnki.zhjbkz.2019.07.021

1.
Department of Obstetrics and Gynecoloty, Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, China
2.
Department of Gynecology and Obstetrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210036, China
3.
School of public health, Southeast university, Nanjing 210009, China

Funds:

National Natural Science Foundation of China 81872684

Natural Science Foundation of Jiangsu Province BK20171367

More Information

Corresponding author: WANG Shi-zhi, E-mail: shizhiwang2009@seu.edu.cn
Received Date: 2019-01-22
Rev Recd Date: 2019-04-01
Publish Date: 2019-07-10

Abstract

Abstract

Objective To investigate the relationship between tumor necrosis factor α (TNF-α) rs1800629 polymorphisms and cervical cancer risk. Methods A case-control study was carried out including 552 patients with cervical cancer and 654 normal controls during the same period. TNF-α rs1800629 polymorphisms were examined by Taqman-Probe assay method. The association between the genotypes and cervical cancer was analyzed by Logistic regression models. Stata 11.0 was used for the Meta-analysis. Results Compared with the TNF-α rs1800629 GG genotype, individuals with GA, AA and GA/AA genotypes showed no significant changes in the risk of cervical cancer (all P>0.05). Further Meta-analysis on the relationship between the polymorphisms of TNF-α rs1800629 and cervical cancer also suggested that there was no significant correlation between the genetic variation and the occurrence of cervical cancer. Conclusion The polymorphisms of TNF-α rs1800629 may not be related to cervical cancer risk in Chinese population.
- TNF-α,
- rs1800629,
- Polymorphism,
- Cervical cancer

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References(19)

References

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