A case-control study of venous blood chromium levels before delivery and preeclampsia

LI Wang-jun; LI Jin-bo; GUO Meng-zhu; REN Qing-wen; FENG Yong-liang; YANG Hai-lan; ZHANG Ya-wei; WANG Su-ping; WU Wei-wei

doi:10.16462/j.cnki.zhjbkz.2022.07.009

Volume 26 Issue 7

Jul. 2022

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2022 > 26(7): 798-802

LI Wang-jun, LI Jin-bo, GUO Meng-zhu, REN Qing-wen, FENG Yong-liang, YANG Hai-lan, ZHANG Ya-wei, WANG Su-ping, WU Wei-wei. A case-control study of venous blood chromium levels before delivery and preeclampsia[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(7): 798-802. doi: 10.16462/j.cnki.zhjbkz.2022.07.009

Citation:

LI Wang-jun, LI Jin-bo, GUO Meng-zhu, REN Qing-wen, FENG Yong-liang, YANG Hai-lan, ZHANG Ya-wei, WANG Su-ping, WU Wei-wei. A case-control study of venous blood chromium levels before delivery and preeclampsia[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(7): 798-802. doi: 10.16462/j.cnki.zhjbkz.2022.07.009

Citation:

LI Wang-jun, LI Jin-bo, GUO Meng-zhu, REN Qing-wen, FENG Yong-liang, YANG Hai-lan, ZHANG Ya-wei, WANG Su-ping, WU Wei-wei. A case-control study of venous blood chromium levels before delivery and preeclampsia[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(7): 798-802. doi: 10.16462/j.cnki.zhjbkz.2022.07.009

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A case-control study of venous blood chromium levels before delivery and preeclampsia

doi: 10.16462/j.cnki.zhjbkz.2022.07.009

1.
Department of Epidemiology, School of Public Health, Shanxi Medical University, Taiyuan 030001, China
2.
Obstetrics and Gynecology, First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001, China
3.
National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China

Funds:

National Natural Science Foundation of China 81703314

Scientific and Technological Innovation Project of Higher Education Institutions in Shanxi Province 2019L0439

Fund Program for the Scientific Activities of Selected Returned Overseas Professionals in Shanxi Province 20210042

More Information

Corresponding author: WU Wei-wei, E-mail: wuweiwei2008@sina.com
Received Date: 2021-10-26
Rev Recd Date: 2022-04-07

Available Online: 2022-07-19

Publish Date: 2022-07-10

Abstract

Abstract

Objective To investigate the relationship between chromium (Cr) exposure during pregnancy and the risk of preeclampsia (PE) and its clinical subtypes. Methods The research subjects were pregnant women who gave birth in the Obstetrics department of the First Hospital of Shanxi Medical University from March 2012 to September 2016. A total of 442 cases of PE [195 cases of early-onset PE (EOPE) and 247 cases of late-onset PE (LOPE)] and 1 745 normal pregnant women were randomly selected. The general demographic characteristics, disease history, family history, etc. were collected, and the concentration of heavy metal Cr in whole blood was detected. Unconditional Logistic regression was used to analyze the level of Cr exposure and the risk of PE and its clinical subtypes. Results The whole blood Cr exposure level of pregnant women in the PE group was [9.54 (3.40, 39.26)] μg/L, that in the EOPE group was [9.75 (3.56, 55.38)] μg/L, and that in the LOPE group was [9.36 (3.21, 39.24)] μg/L, which were higher than that of normal pregnant women with [7.02 (0.10, 30.05)] μg/L (all P < 0.05). Using unconditional Logistic regression analysis, after adjusting for confounding factors such as pregnant women's age, education level, and per capita monthly income, Cr exposure levels were related to the risk of PE and its different clinical subtypes, and it was associated with a higher risk of EOPE. Conclusion Cr exposure in pregnancy is related to the risk of PE, and is more related to the risk of EOPE.
- Preeclampsia,
- Chromium exposure,
- Pregnancy,
- Whole blood

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References(21)

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