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CN 34-1304/RISSN 1674-3679

Volume 26 Issue 7
Jul.  2022
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YU Kai-li, LIN Zheng, QIU Mo-liang, LIU Shuang, XIE Qian-wen, RAO Wen-qing, CHEN Yuan-mei, LIN Jian-bo, HU Zhi-jian. A study on the interaction effect of platelet count and sex on prognosis in patients with esophageal squamous cell carcinoma after esophagectomy[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(7): 820-826. doi: 10.16462/j.cnki.zhjbkz.2022.07.013
Citation: YU Kai-li, LIN Zheng, QIU Mo-liang, LIU Shuang, XIE Qian-wen, RAO Wen-qing, CHEN Yuan-mei, LIN Jian-bo, HU Zhi-jian. A study on the interaction effect of platelet count and sex on prognosis in patients with esophageal squamous cell carcinoma after esophagectomy[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2022, 26(7): 820-826. doi: 10.16462/j.cnki.zhjbkz.2022.07.013

A study on the interaction effect of platelet count and sex on prognosis in patients with esophageal squamous cell carcinoma after esophagectomy

doi: 10.16462/j.cnki.zhjbkz.2022.07.013
Funds:

National Key Research and Development Program of China 2017YFC0907100

Medical Innovation Project of Fujian Province 2018-CX-38

More Information
  • Corresponding author: HU Zhi-jian, E-mail: hzj99955888@126.com
  • Received Date: 2021-03-01
  • Rev Recd Date: 2021-08-04
  • Available Online: 2022-07-19
  • Publish Date: 2022-07-10
  •   Objective  To investigate the prognostic value of the preoperative platelet count (PLT) and its interactions with gender and age in patients with esophageal squamous cell carcinoma (ESCC) after esophagectomy.  Methods  A total of 582 patients with ESCC were eligible for retrospective analysis between February 1, 2014, and November 30, 2018. The survival rate was calculated using the Kaplan-Meier method and the comparison of the two groups was performed by using the Log-rank test. Univariate and multivariate analyses were calculated using the Cox proportional hazards regression model to determine prognostic factors associated with overall survival (OS) and disease-free survival(DFS). Hazard ratios (HRs) and (95% CI) were used as common measures to assess relative risk.  Results  PLT only interacted with gender (HR=2.417, 95% CI: 1.150-5.078, P=0.018). Stratified analysis showed that PLT increased group was independently associated with a 71.3% risk increase for death compared with PLT normal group (HR=1.713, 95% CI: 1.203-2.441, P=0.003) in male patients; While in female patients, there was no statistical significance between groups (HR=0.590, 95% CI: 0.299-1.165, P=0.129).  Conclusions  There is an interaction between PLT and gender in predicting the prognosis of patients with ESCC after esophagectomy. Gender differences should be paid attention to when PLT is chosen to be a prognostic factor.
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