2013-2014年度季节性流行性感冒疫苗对儿童保护效果的病例对照研究

贺晴; 许建雄; 王鸣; 沈纪川; 张春焕; 傅传喜

doi:10.16462/j.cnki.zhjbkz.2016.10.013

2013-2014年度季节性流行性感冒疫苗对儿童保护效果的病例对照研究

doi: 10.16462/j.cnki.zhjbkz.2016.10.013

1. 广州市疾病预防控制中心免疫规划部, 广东广州 510440;
2. 广州市疾病预防控制中心基层公共卫生部, 广东广州 510440

详细信息

作者简介:
贺晴(1987-),女,湖南湘乡人,医师,硕士。主要研究方向:传染病的流行及控制。

中图分类号: R186.31;R511.7;R979.5
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- 被引次数: 0
出版历程
- 收稿日期: 2016-04-27
- 修回日期: 2016-07-21

A case-control study of effectiveness of seasonal influenza vaccine in children in 2013-2014

1. Department of Immunization Programme Planning, Center for Disease Control and Prevention of Guangzhou, Guangzhou 510440, China;
2. Department of Primary Public Health, Center for Disease Control and Prevention of Guangzhou, Guangzhou 510440, China

摘要

摘要: 目的评价2013-2014年度季节性流行性感冒疫苗（流感疫苗）对6~59月龄儿童的保护效果。方法选择2013-2014年度6~59月龄的实验室诊断流感病例为病例组，在广州市免疫规划系统中随机选择健康儿童为对照组，进行成组病例对照研究，采用非条件Logistic回归计算保护效果。结果本研究共纳入2 690名研究对象。2013-2014年度，流感疫苗对6~59月龄儿童的保护效果为42.3%（95% CI：27.8%~53.8%），对36~59月龄儿童的保护效果高于6~35月龄儿童，完全免疫的保护效果高于部分免疫，性别间保护效果无统计学差异。结论流感疫苗对6~59月龄儿童具有中等保护效果，建议6~59月龄儿童每年接种流感疫苗。
- 流感,人 /
- 疫苗 /
- 病例对照研究
Abstract: Objective To estimate the effectiveness of seasonal influenza vaccine in 2013-2014. Methods A category matching case-control study was conducted among children aged 6 to 59 months. The laboratory confirmed influenza cases were randomly selected from surveillance sites in Guangzhou during the study period. The healthy controls were randomly selected from children aged 6 to 59 months in the children's expanded programmed immunization administrative computerized system. Vaccine effectiveness (VE) was analyzed by unconditional Logistic regression. Results 2 690 subjects were collected in our study. We found that the VE for vaccination in 2013-2014 for children aged 6 to 59 months was 42.3%(95% CI:27.8%-53.8%). Full vaccination provided more protection than partial vaccination. Conclusions This post-licensing study of VE found moderate protection against influenza for vaccinated children aged 6 to 59 months. Annual and full vaccination should be encouraged in children.
- Influenza, human /
- Vaccines /
- Case-control studies

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