安徽省耐多药肺结核危险因素病例对照研究

余述凤; 梅晓冬; 阚晓宏; 方雪晖; 包训迪

doi:10.16462/j.cnki.zhjbkz.2016.10.015

安徽省耐多药肺结核危险因素病例对照研究

doi: 10.16462/j.cnki.zhjbkz.2016.10.015

余述凤^1,2,
梅晓冬^1, ,,
阚晓宏^3, ,,
方雪晖³,
包训迪⁴

1. 安徽医科大学附属安徽省立医院呼吸内科, 安徽合肥 230001;
2. 安徽省胸科医院呼吸内科, 安徽合肥 230022;
3. 安徽省胸科医院科教科, 安徽合肥 230022;
4. 安徽省胸科医院检验科, 安徽合肥 230022

基金项目:

安徽省卫计委科研基金（2011Y0107）

详细信息

作者简介:
余述凤(1980-),女,安徽合肥人,主治医师,在读硕士研究生。主要研究方向:呼吸系统疾病。

中图分类号: R521;R181.2
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- 被引次数: 0
出版历程
- 收稿日期: 2016-05-10
- 修回日期: 2016-07-26

Risk factors of multidrug-resistant tuberculosis in Anhui Province: A case-control study

1. Department of Respiratory Medicine, Anhui Provincial Hospital affiliated to Anhui Medical University, Hefei 230001, China;
2. Department of Respiratory Medicine, Anhui Provincial Chest Hospital, Hefei 230022, China;
3. Department of Science and Technology, Anhui Provincial Chest Hospital, Hefei 230022, China;
4. Department of Clinical Laboratory, Anhui Provincial Chest Hospital, Hefei 230022, China

摘要

摘要: 目的探讨安徽省耐多药肺结核的危险因素。方法采用病例对照研究方法，病例组为83名耐多药肺结核病人，对照组为98名已治愈的非耐药肺结核病人，以问卷调查形式收集资料。结果居住地为农村、文化程度为初中及以下、家庭人均月收入少、外出务工、吸烟、服用抗结核药物产生不良反应、既往抗肺结核治疗次数多、既往有某个疗程中暂时停药或暂时中断治疗、首次确诊时X线检查肺内病灶多、空洞多、首次抗结核治疗效果未治愈都是耐多药肺结核的危险因素（均有P<0.05）；病人接受过结核病知识以及治疗过程中有关服药原则的宣传和教育、>7 h的睡眠时间是耐多药肺结核的保护因素（均有P<0.05）。结论导致安徽省耐多药肺结核发生的危险因素较多，适当的宣传教育和充足的睡眠有助于减少耐多药肺结核的发生。
- 广泛耐药结核 /
- 危险因素 /
- 病例对照研究
Abstract: Objective To investigate the risk factors of multidrug-resistant tuberculosis in Anhui Province. Methods 83 patients with multidrug-resistant pulmonary tuberculosis and 98 cured patients with non drug-resistant pulmonary tuberculosis were collected and analyzed with case-control study. Results Rural residence, junior high school education level and below, less family month income, migrant work, smoking, experience of adverse reactions of anti-tuberculosis drugs, history of repeated tuberculosis treatment, history of discontinuation or temporary interruption of anti-tuberculosis therapy, lung X ray image with multiple lesions or cavities when tuberculosis was diagnosed, and once first treatment failure were risk factors of multidrug-resistant tuberculosis (all P<0.05); equipped with tuberculosis knowledge or related medication taking principle popularization and sleeping time >7 hours were protective factors (all P<0.05). Conclusions The risk factors of multidrug-resistance tuberculosis in Anhui Province are various. Adequate tuberculosis education and sufficient sleep might be beneficial to the disease.
- Extensively drug-resistant tuberculosis /
- Risk factors /
- Case-control studies

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参考文献(15)

孔雯,刘巧,陆伟,等. 标准化耐多药肺结核化疗方案的不良反应及治疗转归情况分析[J]. 中华疾病控制杂志, 2014,18(7):610-612.

Becerra MC, Franke MF, Appleton SC, et al. Tuberculosis in children exposed at home to multidrug-resistant tuberculosis[J]. Pediatr Infect Dis J, 2013,32(2):115-119.

Seddon JA, Thee S, Jacobs K, et al. Hearing loss in children treated for multidrug-resistant tuberculosis[J]. J Infect, 2013,66(4):320-329.

王伟,刘京铭,李传友,等. WHO 2014年版《耐药结核病规划管理指南伙伴手册》解读之五(耐药结核病实验室检测)[J]. 中国防痨杂志, 2015,37(6):655-658.

李镒冲,张梅,姜勇,等. 中国2012年18~59岁就业流动人口饮酒现状分析[J]. 中华流行病学杂志, 2014,35(11):1186-1191.

刘佳,王佑民,冯双双. 吸烟对2型糖尿病男性患者血脂水平的影响[J]. 安徽医科大学学报, 2015,50(2): 198-201.

肖东楼. 全国结核病耐药性基线调查报告(2007-2008年)[M]. 北京:人民卫生出版社, 2010.

Zhao P, Li XJ, Zhang SF, et al. Social behaviour risk factors for drug resistant tuberculosis in mainland China: a meta-analysis[J]. J Int Med Res, 2012,40(2):436-445.

Hayashi S, Takeuchi M, Hatsuda K, et al. The impact of nutrition and glucose intolerance on the development of tuberculosis in Japan[J]. Int J Tuberc Lung Dis, 2014,18(1):84-88.

Keshavjee S, Gelmanova IY, Shin SS, et al. Hepatotoxicity during treatment for multidrug-resistant tuberculosis: occurrence, management and outcome[J]. Int J Tuberc Lung Dis, 2012,16(5):596-603.

Franke MF, Appleton SC, Bayona J, et al. Risk factors and mortality associated with default from multidrug-resistant tuberculosis treatment[J]. Clin Infect Dis, 2008,46(12):1844-1851.

Cobo J, Asensio A, Moreno S, et al. Risk factors for nosocomial transmission of multidrug-resistant tuberculosis due to Mycobacterium bovis among HIV-infected patients[J]. Int J Tuberc Lung Dis, 2001,5(5):413-418.

Yu HT, Wang Q, Yang N, et al. Risk factors associated with kanamycin-resistant tuberculosis in a Beijing tuberculosis referral hospital[J]. J Med Microbiol, 2012,61(Pt7):960-967.

Tessema B, Beer J, Emmrich F, et al. First-and second-line anti-tuberculosis drug resistance in Northwest Ethiopia[J]. Int J Tuberc Lung Dis, 2012,16(6):805-811.

Gler MT, Podewils LJ, Munez N, et al. Impact of patient and program factors on default during treatment of multidrug-resistant tuberculosis[J]. Int Tuberc Lung Dis, 2012,16(7): 955-960.

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