广东省人群多重耐药金葡菌的携带及耐药性分析

余海峰; 王晓霖; 樊燕平; 姚振江; 陈思东; 叶小华

doi:10.16462/j.cnki.zhjbkz.2016.10.019

广东省人群多重耐药金葡菌的携带及耐药性分析

doi: 10.16462/j.cnki.zhjbkz.2016.10.019

1. 佛山市顺德区勒流医院职业病科, 广东佛山 528322;
2. 广东药科大学公共卫生学院流统系, 广东广州 510310

基金项目:

广东省教育厅青年创新人才类项目（广东药学院创新强校工程资助，2014KQNCX138）；佛山市顺德区医学科研基金（2015A005）

详细信息

作者简介:
余海峰(1968-),男,广东顺德人,主管医师,学士。主要研究方向:职业卫生与传染病控制。

中图分类号: R12;R184
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出版历程
- 收稿日期: 2016-05-25
- 修回日期: 2016-08-25

Carriage rate and antibiotic resistance of multidrug-resistant S. aureus isolates among residents in Guangdong Province

1. Department of Occupation, Leliu Hospital of Shunde, Foshan 528322, China;
2. Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China

摘要

摘要: 目的调查广东省部分人群（动物从业人员和一般人群）的多重耐药金葡菌（multidrug-resistant S. aureus，MDRSA）携带情况，并分析菌株的耐药性。方法对研究对象进行问卷调查和鼻拭子采样，对金葡菌进行药敏试验，分析方法采用χ²检验。结果动物从业人员中金葡菌、MDRSA、甲氧西林耐药金葡菌（methicillin-resistant S. aureus，MRSA）的携带率均高于对照人群（分别为13.3% vs 9.3%；9.5% vs 3.4%；7.0% vs 1.4%；均有P<0.01）。金葡菌对青霉素、克林霉素、四环素和红霉素的耐药率较高，MDRSA主要耐药模式是同时对克林霉素、红霉素、四环素耐药。除了青霉素外，动物从业人员金葡菌对各类抗生素的耐药率均高于对照人群；MRSA菌株对各类抗生素的耐药率均高于甲氧西林敏感金葡菌。结论本研究提示职业性动物接触可能导致从业人员感染耐药细菌。
- 葡萄球菌,金黄色 /
- 职业暴露 /
- 流行病学方法
Abstract: Objective To investigate the carriage rate and antibiotic resistance of multidrug-resistant S. aureus among animal-related workers and general population in Guangdong Province. Methods We surveyed the study population by face-to-face questionnaire and nasal swab sampling. All S. aureus isolates were tested for antibiotic susceptibility test, and the data were analyzed by chi-squared test. Results The carriage rates of S. aureus, multidrug-resistant S. aureus and methicillin-resistant S. aureus (MRSA) were higher in animal-related workers than in controls (13.3% vs 9.3%; 9.5% vs 3.4%; 7.0% vs 1.4%; all P<0.01). The rates of S. aureus isolates showed high levels of resistance to penicillin, clindamycin, tetracycline and erythromycin, and the dominant multidrug resistance pattern of multidrug-resistant S. aureus isolates were mainly resistant to clindamycin, erythromycin and tetracycline. S. aureus strains isolated from animal-related workers showed higher levels of resistances to antibiotics, except for penicillin, than those from general population. The antibiotic-resistant rate was higher in MRSA isolates than in methicillin-sensitive S. aureus isolates. Conclusions This study suggests that occupational animal contact may lead to the infection of drug resistant bacteria.
- Staphylococcus aureus /
- Occupational exposure /
- Epidemiologic methods

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