Abstract: Objective To investigate the current status of depression and sleep quality among pregnant women in the late pregnancy and its influencing factors, and to explore the relationship between depression and sleep quality in late pregnant women. Methods A total of 535 pregnant women were selected from 2 hospitals in Zhongwei city and the questionnaire survey were conducted, the quality of sleep and depression in pregnant women were evaluated using pittsburgh sleep quality index questionnaire (PSQI) and self-rating depression scale (SDS). Results Among the 535 pregnant women, 34.2% of them had depression symptoms, 20.6% of them had sleep disorder. The detection rate of sleep disorders in pregnant women with depression (29.0%) was higher than those among the pregnant women without depression (16.2%), and the difference was statistically significant (χ²=12.018, P=0.001). There was a positive relationship between the total score of PSQI and the score of SDS (r=0.680, P<0.001). Results of Multivariate logistic regression analysis showed that low level of education,poor relationship between husband and wife, pregnancy complications and sleep disorders were important risk factors of depressive symptom. Pregnancy complications, worry about children's health and depression were risk factors for sleep disorders in the late pregnancy. Conclusions There is a positive relationship between sleep quality and depression in late pregnant women, and comprehensive intervention measures should be taken to improve the depression and sleep quality of pregnant women in the late pregnancy.