Study on serum uric as an additional component for screening the metabolic syndrome in adult
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摘要: 目的 检验血尿酸浓度对代谢综合征的诊断能力,分析血尿酸水平对福建省居民代谢综合征的影响。方法 采用随机抽样的方法在福建省10个县调查收集6 134名居民体检和实验室检测资料,分析血尿酸水平对代谢综合征的筛检能力,及血尿酸对代谢综合征的影响。结果 福建省人群男女代谢综合征患病率分别为19.00%和12.70%,含有代谢综合征组份越多的人群,尿酸水平越高,男性尿酸水平筛检代谢综合征的临界值为412.95 μmol/L,受试者工作特征曲线下面积、灵敏度、特异度、阳性预测值、阴性预测值分别为0.635、51.02%、59.74%、28.34%和85.86%;女性人群中血尿酸浓度>310.30 μmol/L时,曲线下面积为0.674,灵敏度、特异度、阳性预测值、阴性预测值分别为63.33%、63.04%、19.35%和92.20%。经过校正年龄和居住地后,男、女性高血尿酸组患代谢综合征的危险度分别是低血尿酸组2.571(2.116~3.124)和2.806(2.249~3.502)倍。结论 通过血尿酸诊断代谢综合征的有一定的临床意义,高血尿酸是代谢综合征及其组份的危险因素。Abstract: Objective To evaluate the diagnostic ability of serum uric acid in identifying metabolic syndrome, and analyze the effects of serum uric acid on metabolic syndrome in Fujian residents. Methods Physical and biomedical data of 6 134 residents randomly selected from 10 counties/districts in Fujian province were collected for the analysis of the screening ability and the influence of serum uric acid on metabolic syndrome. Results The prevalence of metabolic syndrome in male and female populations in Fujian were 19.00% and 12.70%, respectively. The residents consisted with more metabolic syndrome subjects had higher serum uric acid levels.The critical value of serum uric acid for screening metabolic syndrome in the male residents was 412.95 μmol/L, The area under curve (AUC), sensitivity, specificity, positive prediction value(PPV), nagative prediction value(NPV) of receiver operating characteristic curve (ROC) was 0.635,51.02%,59.74%,28.34%and 85.86%, respectively. In the female population, AUC of ROC was 0.674 for SUA above 310.30 μmol/L, the sensitivity, specificity, PPV, NPV was 63.33%, 63.04%,19.35%and 92.20%, respectively. After adjustment by age and place of residence the risk of metabolic syndrome in male and female high serum uric acid groups was 2.571(2.116-3.124)and 2.806(2.249-3.502)times higher than those in the low serum uric acid groups. Conclusions Using serum uric acid for diagnosing metabolic syndrome has certain clinical significance and high serum uric acid is a risk factor for metabolic syndrome.
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Key words:
- Serum uric acid /
- Metabolic syndrome /
- Cross-section /
- ROC
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