2013-2018年南昌市重症肺炎病例中甲型流感病毒感染状况分析

贺凤兰; 夏文; 倪贤生; 宋文涛; 樊国印; 涂俊凌; 吴景文

doi:10.16462/j.cnki.zhjbkz.2019.02.022

2013-2018年南昌市重症肺炎病例中甲型流感病毒感染状况分析

doi: 10.16462/j.cnki.zhjbkz.2019.02.022

330038 南昌, 南昌市疾病预防控制中心微生物检验科

基金项目:

江西省科技计划项目 20151BBG70258

详细信息

通讯作者:
倪贤生, E-mail: nxsh94@163.com

中图分类号: R181;R183.3
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出版历程
- 收稿日期: 2018-08-28
- 修回日期: 2018-11-09
- 刊出日期: 2019-02-10

Analysis of infection status in severe pneumonia cases infection with influenza A virus in Nanchang from 2013 to 2018

Microbiology Laboratory Nanchang Center for Disease Control and Prevention, Nanchang 330038, China

Funds:

Jiangxi Science and Technology Project 20151BBG70258

More Information

Corresponding author: NI Xian-sheng, E-mail: nxsh94@163.com

摘要

摘要: 目的分析南昌市重症肺炎病例的甲型流感病毒分布特征和发病特点，为重症肺炎病例的临床防治提供依据。方法收集2013年4月~2018年3月南昌市重症肺炎病例的呼吸道样本和病例资料，进行病原学和流行病学分析。结果 2013年4月~2018年3月共检测来自南昌市17家医疗机构的261例重症肺炎病例，检出甲型流感病毒核酸阳性77例，总阳性率为29.50%。其中包括39例新甲H1NI病例、13例季节性H3、16例人感染H7N9禽流感、3例人感染H10N8禽流感。甲型流感病毒重症肺炎病例主要发生在冬春季（12月至次年5月），年龄中位数48岁，其中男性48例，女性31例。2013-2018年南昌市报告21例人感染H7N9/H10N8禽流感病例，90.48%（19/21）的病例通过不明原因肺炎监测发现，病死率33.33%。结论南昌市重症肺炎病例中近三成感染甲型流感病毒，其中新甲H1NI流感病毒为主要流行株，死亡病例均为禽流感病毒感染。
- 重症肺炎 /
- 甲型流感病毒 /
- 病原学 /
- 流行病学
Abstract: Objective To explore the distribution and disease characteristics of influenza virus A in severe pneumonia cases in Nanchang city, so as to provide evidence for clinical prevention and treatment of severe pneumonia cases. Methods The respiratory samples and clinical case data of severe pneumonia cases were collected and the etiology and epidemiology were analyzed in Nanchang from April 2013 to March 2018. Results From April 2013 to March 2018, 261 case patients of severe pneumonia from 17 medical institutions in Nanchang were enrolled. 77 cases was detected as positive for influenza A virus nucleic acid, accounting for 29.50% of the total cases, as follow: 39 cases of A (H1N1pdm) influenza, 13 A (H3), 16 H7N9 and 3 H10N8 avian influenza. Cases were mainly concentrated in winter and spring (from December to May of next year, with median age 48 of years, including 48 males and 31 females. 21 cases of human infection with H7N9/H10N8 avian influenza were reported in Nanchang during 5 years, with the fatality rate of 33.33%. 90.48% (19/21) cases were detected by unexplained pneumonia surveillance system. The median age was 69 years, most of them had underlying diseases and a clear history of poultry contact. Conclusions Nearly 30% of the severe pneumonia cases in Nanchang city were infected with influenza A virus, among which influenza A (H1N1pdm) virus was the main epidemic strain. All deaths were caused by avian influenza virus infection.
- Severe pneumonia /
- Influenza A virus /
- Etiology /
- Epidemiology

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图 1 2013-2018年南昌市重症肺炎病例甲型流感病毒检出时间分布

Figure 1. Detection time distribution of influenza A virus in severe pneumonia cases in Nanchang from 2013 to 2018

下载: 全尺寸图片幻灯片

表 1 2013-2018年南昌市重症肺炎及人感染禽流感病例地区分布

Table 1. Regional distribution of severe pneumonia cases and human infection with avian influenza in Nanchang from 2013 to 2018

县区	检测数(例)	阳性数(例)	阳性率(%)	人禽流感例数
县区	检测数(例)	阳性数(例)	阳性率(%)	H7N9	H10N8
东湖区	25	13	48.00	1	2
青山湖区	38	13	34.21	1	1
安义县	6	2	33.33	0	0
南昌县	20	6	30.00	3	0
西湖区	40	11	28.95	4	0
青云谱区	7	2	14.29	0	0
新建区	18	5	23.53	1	0
进贤县	9	1	11.11	0	0
湾里区	1	0	0.00	0	0
不详县区	3	0	0.00	0	0
合计	167	55	31.33	10	3

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表 2 2013-2018年南昌市甲型流感病毒重症肺炎病例人群分布

Table 2. Population distribution in severe pneumonia cases infection with influenza A virus in Nanchang from 2013 to 2018

特征	检测数(例)	阳性数(例)	阳性率(%)	不同型别阳性数(例)
特征	检测数(例)	阳性数(例)	阳性率(%)	新甲H1NI	季节性H3	H7N9	H10N8
型别
男	164	50	28.05	26	8	11	1
女	97	31	31.96	17	5	7	2
年龄(岁)
0~	23	8	34.78	7	1	0	0
20~	50	21	42.00	17	2	2	0
40~	79	26	28.40	15	2	5	1
≥60	103	24	23.36	4	7	11	2
合计	261	77	29.50	43	12	18	3

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