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湖北省HIV感染人群戊型肝炎流行病学调查

陈雅梦,  尹玲,  张宏伟,  王恒琦,  申鑫,  占建波,  郑武,  疏义林,  张玲

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文章导航 > 中华疾病控制杂志  > 2019 >  23(4): 392-396
陈雅梦, 尹玲, 张宏伟, 王恒琦, 申鑫, 占建波, 郑武, 疏义林, 张玲. 湖北省HIV感染人群戊型肝炎流行病学调查[J]. 中华疾病控制杂志, 2019, 23(4): 392-396. doi: 10.16462/j.cnki.zhjbkz.2019.04.005
引用本文: 陈雅梦, 尹玲, 张宏伟, 王恒琦, 申鑫, 占建波, 郑武, 疏义林, 张玲. 湖北省HIV感染人群戊型肝炎流行病学调查[J]. 中华疾病控制杂志, 2019, 23(4): 392-396. doi: 10.16462/j.cnki.zhjbkz.2019.04.005
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CHEN Ya-meng, YIN Ling, ZHANG Hong-wei, WANG Heng-qi, SHEN Xin, ZHAN Jian-bo, ZHENG Wu, SHU Yi-lin, ZHANG Ling. Epidemiological survey and study of hepatitis E virus among HIV-infected population in Hubei Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(4): 392-396. doi: 10.16462/j.cnki.zhjbkz.2019.04.005
Citation: CHEN Ya-meng, YIN Ling, ZHANG Hong-wei, WANG Heng-qi, SHEN Xin, ZHAN Jian-bo, ZHENG Wu, SHU Yi-lin, ZHANG Ling. Epidemiological survey and study of hepatitis E virus among HIV-infected population in Hubei Province[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(4): 392-396. doi: 10.16462/j.cnki.zhjbkz.2019.04.005
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湖北省HIV感染人群戊型肝炎流行病学调查

doi: 10.16462/j.cnki.zhjbkz.2019.04.005
  • 1.

    430065 武汉市, 武汉科技大学医学院公共卫生学院, "职业危害识别与控制"湖北省重点实验室

  • 2.

    430065 武汉市, 武汉科技大学医院

  • 3.

    241000 芜湖市, 安徽师范大学生命科学学院

  • 4.

    430079 武汉市, 湖北省疾病预防控制中心

基金项目: 

国家自然科学基金 81573239

湖北省卫生和计划生育委员会面上项目 WJ2017M174

湖北省卫生和计划生育委员会面上项目 WJ2017M240

详细信息
    通讯作者:

    张玲, E-mail: zhangling@wust.edu.cn

    疏义林, E-mail: sjshuyilin@163.com

  • 中图分类号: R512.65;R373.51

Epidemiological survey and study of hepatitis E virus among HIV-infected population in Hubei Province

  • 1.

    School of Public Health, Wuhan University of Science and Technology, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Wuhan 430065, China

  • 2.

    Wuhan University of Science and Technology Hospital, Wuhan 430065, China

  • 3.

    College of Life Science, Anhui Normal University, Wuhu 241000, China

  • 4.

    Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China

Funds: 

National Natural Science Foundation of China 81573239

General Projects of Health and Family Planning Commission of Hubei Province of China WJ2017M174

General Projects of Health and Family Planning Commission of Hubei Province of China WJ2017M240

More Information

    摘要
  • 摘要:   目的  了解湖北省人类免疫缺陷病毒(human immunodeficiency virus，HIV)感染人群中戊型肝炎病毒(hepatitis E virus，HEV)的流行情况，为戊型肝炎和艾滋病防治提供有效依据。  方法  于2017年1~6月在湖北省不同地域收集335例HIV感染人群血清样本并进行抗-HEV IgM、抗-HEV IgG检测。  结果  335名HIV感染人群的抗-HEV IgG阳性率为41.49%(139/335)，抗-HEV IgM阳性率为0.89%(3/335)。抗-HEV IgG阳性率与年龄无线性相关(χ趋势2=0.756，P=0.385)，各年龄组间差异均无统计学意义(均有P>0.05)。男女性抗-HEV IgG阳性率差异无统计学意义(χ2=0.085，P=0.771)。CD4 ≤ 200 cell/μl与CD4>200 cell/μl两组间抗-HEV IgG阳性率差异无统计学意义(χ2=1.016，P=0.314)。三例抗-HEV IgM阳性CD4值分别为222 cell/μl，446 cell/μl和198 cell/μl。湖北省东部(30.77%，32/1 041)与中部(47.92%，46/96)HIV感染人群抗-HEV IgG阳性率差异有统计学意义(χ2=6.169，P=0.013)，与东南部抗-HEV IgG阳性率差异有统计学意义(χ2=5.034，P=0.025)。  结论  湖北省HEV病毒在HIV感染人群中流行度较高，需要进行进一步研究并及时采取有效措施进行预防控制。
    Abstract:   Objective  To determinate the seroprevalence of hepatitis E virus (HEV) exposition among HIV-infected people in Hubei Province so as to provide basic data for effective prevention and control of HIV and hepatitis E virus.  Methods  A total of 335 serum samples of HIV-infected people were collected from January to June 2017.Serum samples were subjected to anti-HEV IgG andanti-HEV IgM screening. Data were statistically analyzed.  Results  In 335 HIV-infected people, 0.89% (3/335) of serum samples were anti-HEV IgM positive and 41.49% (139/335) of them were anti-HEV IgG positive.The anti-HEV IgG positive rate was not linearly correlated with age (χ2linear=0.756, P=0.385), and there was no significant difference between the age groups (P>0.05). There was no significant difference in anti-HEV IgG positive rate between different gender(χ2=0.085, P=0.771).Anti-HEV IgG positive rate for the crowd with CD4 value ≤ 200 cell/μl was higher than that with CD4 >200 cell/μl, but showed no significant difference(χ2=1.016, P=0.314), and CD4 indexes of three positive anti-HEV IgM patients were 222, 446 and 198 in cell/μl.The anti-HEV IgG positive rate in HIV-infected population in eastern Hubei (30.77%, 32/1 041) was statistically different from that in central Hubei (47.92%, 46/96) (χ2=6.169, P=0.013), and it was also different from that in southeastern Hubei (45.79%, 49/107) (χ2=5.034, P=0.025).  Conclusions  There were higher HEV infection rate among HIV-infected people in Hubei Province; thus, it is essential to positively carry out double-way screening for these two diseases at the same time, and effective prevention and control of these viruses are required.
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  • 图  1  湖北省地图(来源于网络)

    Figure  1.  Map of Hubei Province (from the network)

    下载: 全尺寸图片 幻灯片

    表  1  湖北省HIV感染人群不同年龄组抗-HEV IgG的分布

    Table  1.   The distribution of anti-HEV IgG among different age groups for HIV-infected people in Hubei Province

    年龄(岁) 检查人数 阳性人数 抗-HEV IgG阳性率(%)
    ≤30 50 18 36.00
    31~ 66 24 36.36
    41~ 81 34 41.98
    51~ 68 36 52.94
    61~ 48 19 39.58
    ≥70 22 8 36.36
    合计 335 139 41.49
    下载: 导出CSV

    表  2  湖北省HIV感染人群不同性别间抗-HEV IgG的分布

    Table  2.   The distribution of anti-HEV IgG among different gender groups for HIV-infected people in Hubei Province

    性别 检查人数 阳性人数 抗-HEV IgG阳性率(%)
    男 243 102 41.98
    女 92 37 40.22
    合计 335 139 41.49
    下载: 导出CSV

    表  3  湖北省HIV感染人群不同CD4值间抗-HEV IgG的分布

    Table  3.   The distribution of anti-HEV IgG among different CD4 value for HIV-infected people in Hubei Province

    CD4值(cell/μl) 检查人数 阳性人数 抗-HEV IgG阳性率(%)
    ≤200 66 31 46.97
    ＞200 269 108 40.15
    合计 335 139 41.49
    下载: 导出CSV

    表  4  湖北省HIV感染人群抗-HEV IgG不同区域的分布

    Table  4.   The distribution of anti-HEV IgG among different areas for HIV-infected people in Hubei Province

    地区 检查人数 阳性人数 抗-HEV IgG阳性率(%)
    东部 104 32 30.77
    中部 96 46 47.92
    东北部 28 12 42.86
    东南部 107 49 45.79
    合计 335 139 41.49
    下载: 导出CSV
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  • 收稿日期:  2018-11-22
  • 修回日期:  2019-01-31
  • 刊出日期:  2019-04-10

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