中国老年人维生素D摄入与认知障碍防治进展

成乐; 赵海峰

doi:10.16462/j.cnki.zhjbkz.2020.05.020

中国老年人维生素D摄入与认知障碍防治进展

doi: 10.16462/j.cnki.zhjbkz.2020.05.020

成乐,
赵海峰^,

030001 山西, 山西医科大学公共卫生学院营养与食品卫生学教研室

基金项目: 国家自然科学基金(81973047, 81472984)

详细信息

通讯作者:
赵海峰, E-mail:haifengzao75@163.com

中图分类号: R151.1
计量
- 文章访问数: 617
- HTML全文浏览量: 233
- PDF下载量: 57
- 被引次数: 0
出版历程
- 收稿日期: 2019-09-16
- 修回日期: 2020-12-15
- 刊出日期: 2020-05-10

Advances in vitamin D intake and prevention of cognitive impairment in Chinese elderly

CHENG Le,
ZHAO Hai-feng^,

Department of Nutrition and Food Hygiene, School of Public Health, Shanxi Medical University, Shanxi 030001, China

Funds: National Natural Science Foundation of China(81973047, 81472984)

More Information

Corresponding author: ZHAO Hai-feng, E-mail:haifengzao75@163.com

摘要

摘要: 中国老年人维生素D参考摄入量自1981年发布至今, 已由400 IU/d增至600 IU/d。但由于户外活动不足或膳食摄入不足等原因, 仍有超1/3的老年人存在维生素D缺乏。维生素D缺乏是阿尔茨海默病(Alzheimer’s Disease, AD)的危险因素之一, 充足的维生素D在AD中起着降低β-淀粉样蛋白沉积、抗炎等重要的作用。本文就≥65岁老年人维生素D参考摄入量修订历程与体内水平现状及其与阿尔茨海默病的关系做一综述。
- 维生素D /
- 参考摄入量 /
- 阿尔茨海默病
Abstract: The reference intake of vitamin D in the elderly has been increased from 400 IU/d to 600 IU/d since its publication in 1981 in China. However, owing to insufficient outdoor activities or insufficient dietary intake, there are still more than one third of the elderly who have vitamin D deficiency. Vitamin D deficiency is one of the risk factors for Alzheimer's Disease(AD). Adequate vitamin D plays an important role in reducing amyloid β-proteindeposition and anti-inflammatory in AD. This review aims to provide an overview of the revision history of vitamin D reference intake and the status of in vivo levels and their relationship with AD in elderly people aged 65 years and older.
- Vitamin D /
- Dietary recommended intakes /
- Alzheimer's disease

HTML全文

表 1 中国≥65岁老年人VD摄入量修订行历程

Table 1. Revision history of VD intake of ≥65 years old in China

年份	RDA/RNI		UL		来源
年份	65岁以下	65岁以上	65岁以下	65岁以上	来源
1981年	400 IU/d	400 IU/d	-		中国每日膳食中营养素供给量修订版
1988年	200 IU/d(16~45岁)	400 IU/d	-		中国每日膳食中营养素供给量第二次修订
2000年	200 IU/d(11~50岁)	400 IU/d	800 IU/d		中国居民膳食营养素参考摄入量
2013年	400 IU/d	600 IU/d	2 000 IU/d		中国居民膳食营养素参考摄入量(2013版)

下载: 导出CSV

参考文献(40)

[1]	Zhang W, Stoecklin E, Eggersdorfer M. A glimpse of vitamin D status in Mainland China[J]. Nutrition, 2013, 29(7-8): 953-957.DOI: 10.1016/j.nut.2013.01.010.
[2]	Shen L, Ji HF. Vitamin D deficiency is associated with increased risk of Alzheimer's disease and dementia: evidence from meta-analysis[J]. Nutr J, 2015, 14(1): 76.DOI: 10.1186/s12937-015-0063-7.
[3]	Afzal S, Bojesen SE, Nordestgaard BG. Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia[J]. Alzheimers Dement, 2014, 10(3): 296-302.DOI: 10.1016/j.jalz.2013.05.1765.
[4]	赫明超, 王拥军, 张岩.维生素D与中枢神经系统疾病关系的研究现状[J].中国临床药理学杂志, 2018, 34(22): 2664-2666, 2677.DOI: 10.13699/j.cnki.1001-6821.2018.22.023. He MC, Wang YJ, Zhang Y. Research progress on the association of vitamin D and central nervous system diseases[J]. Chin J Clin Pharmacol, 2018, 34(22): 2664-2666, 2677. DOI: 10.13699/j.cnki.1001-6821.2018.22.023.
[5]	每日膳食中营养素供给量[J].营养学报, 1981, 3(4): 185-191. Nutrient supply in daily diet[J]. Acta Nutrimenta Sinica, 1981, 3(4): 185-191.
[6]	推荐的每日膳食中营养素供给量的说明[J].营养学报, 1990, 12(1): 1-9. Description of the recommended nutrient supply in the daily diet[J]. Acta Nutrimenta Sinica, 1990, 12(1): 1-9.
[7]	中国营养学会.中国居民膳食营养素参考摄入量[M].北京: 中国轻工业出版社, 2000: 285-286. Chinese Nutrition Society. Dietary recommended intakes[M]. Beijing: China Light Industry Press, 2000: 285-286.
[8]	Vieth R.Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety[J].Am J Clin Nutr, 1999, 65:842-856. http://ndt.oxfordjournals.org/cgi/ijlink?linkType=ABST&journalCode=ajcn&resid=69/5/842
[9]	周建烈, 毛绚霞, 顾景范.维生素D膳食参考摄入量的再评估[J].生理科学进展, 2009, 40(1): 36-40. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=slkxjz200901007 Zhou JL, Mao XX, Gu JF. Update on reassessment of dietary reference intakes(DRIs)for Vitamin D[J]. Progress in Physiological Sciences, 2009, 40(1): 36-40. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=slkxjz200901007
[10]	Kennedy C, Bajdik CD, Willemze R, et al.The influence of painful sunburns and lifetime sun exposure on the risk of actinic kerstoses, seborrheic warts, melanocytic nevi, atypical nevi, and skin cancer[J].J Invest Dermatol, 2003, 120(6):1087-1093. doi: 10.1046/j.1523-1747.2003.12246.x
[11]	Wolpowitz D, Gilchrest BA. The vitamin D questions: how much do you need and how should you get it[J]. J Am Acad Dermatol, 2006, 54(2): 301-317.DOI: 10.1016/j.jaad.2005.11.1057.
[12]	Holick MF.Vitamin D deficiency[J].N Engl J Med, 2007, 357(3):266-281. doi: 10.1056/NEJMra070553
[13]	Hathcock JN, Shao A, Vieth R, et al. Risk assessment for vitamin D[J]. Am J Clin Nutr, 2007, 85(1): 6-18.DOI: 10.1093/ajcn/85.1.6.
[14]	IOM (Institute of Medicine).Dietary reference intakes for calcium and vitamin D (2011)[M].Washington DC: The National Academies Press, 2011..
[15]	中国营养学会.中国居民膳食营养素参考摄入量(2013版)[M].北京: 科学出版社, 2014: 89. Chinese Nutrition Society. Dietary recommended intakes(2013)[M]. Beijing: Science Press, 2014: 89.
[16]	Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline[J]. J Clin Endocrinol Metab, 2011, 96(7): 1911-1930.DOI: 10.1210/jc.2011-0385.
[17]	Holick MF. Vitamin D status: measurement, interpretation, and clinical application[J]. AEP, 2009, 19(2): 73-78.DOI: 10.1016/j.annepidem.2007.12.001.
[18]	陈悦, 周建烈.维生素D缺乏的流行病学研究进展[J].中华临床营养杂志, 2009, 17(5): 316-320.DOI: 10.3760/cma.j.issn.1674-635X.2009.05.016. Chen Y, Zhou JL. Advances in epidemiological studies of vitamin D deficiency[J]. Chin J Clin Nutr, 2009, 17(5): 316-320. DOI: 10.3760/cma.j.issn.1674-635X.2009.05.016.
[19]	Maclaughlin J, Holick MF, Kasper K.Aging decreases the capacity of human skin to produce vitamin D3[J].J Clin Invest, 1985, 76(4):1536. doi: 10.1172/JCI112134
[20]	廖祥鹏, 张增利, 张红红, 等.维生素D与成年人骨骼健康应用指南(2014年标准版)[J].中国骨质疏松杂志, 2014, 20(9): 1011-1030.DOI: 10.3969/j.issn.1006-7108.2014.09.002. Liao XP, Zhang ZL, Zhang HH, et al. Application guideline for vitamin D and bone health in adult Chinese(2014 Standard Edition)vitamin D working group of osteoporosis committee of China gerontological society[J]. Chin J Osteoporos, 2014, 20(9): 1011-1030. DOI: 10.3969/j.issn.1006-7108.2014.09.002.
[21]	Hjelmesaeth J, Roislien J, Hofso D, et al. Plasma 25-hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals: response to Lu et al[J]. Diabetes Care, 2010, 33(1): e13-e13.DOI: 10.2337/dc09-1568.
[22]	Zhao J, Xia W, Nie M, et al. The levels of bone turnover markers in Chinese postmenopausal women: Peking Vertebral Fracture study[J]. Menopause, 2011, 18(11): 1237-1243.DOI: 10.1097/gme.0b013e31821d7ff7.
[23]	Chen J, Yun C, He Y, et al. Vitamin D status among the elderly Chinese population: a cross-sectional analysis of the 2010-2013 China national nutrition and health survey(CNNHS)[J]. Nutr J, 2017, 16(1): 3.DOI: 10.1186/s12937-016-0224-3.
[24]	中国营养学会.中国居民膳食指南2016[M].北京: 人民卫生出版社, 2016: 251. Chinese Nutrition Society. Chinese dietary guideline 2016[M]. Beijing: People's Medical Publishing House, 2016: 251.
[25]	Yao P, Lu L, Hu Y, et al. A dose-response study of vitamin D3 supplementation in healthy Chinese: a 5-arm randomized, placebo-controlled trial[J]. Eur J Nutr, 2016, 55(1): 383-392.DOI: 10.1007/s00394-015-0859-4.
[26]	中国老年保健医学研究会老龄健康服务与标准化分会, 《中国老年保健医学》杂志编辑委员会.老年人维生素D营养素强化补充规范共识[J].中国老年保健医学, 2019, 17(4): 42-45.DOI: 10.3969/j.issn.1672-2671.2019.04.011. China Society for Geriatrics and Medical Care Aged Health Service and Standardization Branch, Editorial Board of Chinese Journal of Geriatric Care. Consensus on vitamin D nutrient fortification supplements for the elderly[J]. Chinese Journal of Geriatric Care, 2019, 17(4): 42-45. DOI: 10.3969/j.issn.1672-2671.2019.04.011.
[27]	鞠康, 周建烈, 陈思路, 等.阿尔茨海默病与维生素D水平的关系[J].中华临床营养杂志, 2013, 21(3): 143-146.DOI: 10.3760/cma.j.issn.1674-635X.2013.03.003. Ju K, Zhou JL, Chen SL, et al. Relationship between serum 25(OH)D level and cognitive function in patients with Alzheimer's disease[J]. Chin J Clin Nutr, 2013, 21(3): 143-146. DOI: 10.3760/cma.j.issn.1674-635X.2013.03.003.
[28]	高畅, 唐志雄, 傅小玲, 等.骨化三醇对阿尔茨海默病治疗效果的影响[J].中日友好医院学报, 2018, 32(3): 152-154, 164.DOI: 10.3969/j.issn.1001-0025.2018.03.006. Gao C, Tang ZX, Fu XL, et al. Clinical study on the effect of calcitriol in the treatment of Alzheimer's disease[J]. Journal of China-Japan Friendship Hospital, 2018, 32(3): 152-154, 164. DOI: 10.3969/j.issn.1001-0025.2018.03.006.
[29]	廖小明, 张冲.维生素D与阿尔茨海默病的关系研究进展[J].广西医科大学学报, 2017, 34(4): 619-623.DOI: 10.16190/j.cnki.45-1211/r.2017.04.035. Liao XM, Zhang C. Advances in research on the relationship between vitamin D and Alzheimer's disease[J]. J Guangxi Med Unive, 2017, 34(4): 619-623. DOI: 10.16190/j.cnki.45-1211/r.2017.04.035.
[30]	Yuan J, Guo X, Wang J, et al. Calcitriol alleviates global cerebral ischemia-induced cognitive impairment by reducing apoptosis regulated by VDR/ERK signaling pathway in rat hippocampus[J]. Brain Research, 2019, 1724: 146430.DOI: 10.1016/j.brainres.2019.146430.
[31]	Gezen-Ak D, Dursun E, Ertan T, et al. Association between vitamin D receptor gene polymorphism and alzheimer'sdisease[J]. Tohoku J Exp Med, 2007, 212(3): 275-282.DOI: 10.1016/j.jns.2016.09.013.
[32]	Lehmann DJ, Refsum H, Warden DR, et al. The vitamin D receptor gene is associated with Alzheimer's disease[J]. Neurosci Lett, 2011, 504(2): 79-82.DOI: 10.1016/j.exger.2015.06.012.
[33]	Lee YH, Kim JH, Song GG. Vitamin D receptor polymorphisms and susceptibility to Parkinson's disease and Alzheimer's disease: a meta-analysis[J]. Neurol Sci, 2014, 35(12): 1947-1953.DOI: 10.1007/s10072-014-1868-4.
[34]	史曜维, 庄晓伟, 朱磊, 等.阿尔茨海默病与维生素D受体基因遗传变异的关联分析[J].中风与神经疾病杂志, 2018, 35(8): 722-725. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zfysjjbzz201808012 Shi YW, Zhuang XW, Zhu L, et al. Association between VDR polymorphisms and susceptibility of alzheimer disease[J]. J Apoplexy and Nerv Dis, 2018, 35(8): 722-725. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zfysjjbzz201808012
[35]	Aleksis R, Oleskovs F, Jaudzems K, et al. Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity[J]. Biochimie, 2017, 140: 176-192.DOI: 10.1016/j.biochi.2017.07.011.
[36]	Jia J, Hu J, Huo X, et al. Effects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with Alzheimer's disease: a randomised, double-blind, placebo-controlled trial[J]. J Neurol Neurosurg Psychiatry, 2019, 0: 1-6.DOI: 10.1136/jnnp-2018-320199.
[37]	Van Eldik LJ, Carrillo MC, Cole PE, et al. The roles of inflammation and immune mechanisms in Alzheimer's disease[J]. Alzheimer's Dement(N Y), 2016, 2(2): 99-109.DOI: 10.1016/j.trci.2016.05.001.
[38]	赵松涛.阿尔茨海默病患者25-羟维生素D水平与炎性因子及氧化应激的相关性分析[J].中国卫生检验杂志, 2018, 28(5): 632-634. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgwsjyzz201805039 Zhao ST. Correlation of 25-hydroxy vitamin D levels with inflammatory factors and oxidative stress in patients with Alzheimer's disease[J]. Chin J Health Lab Tec, 2018, 28(5): 632-634. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgwsjyzz201805039
[39]	Briones T L, Darwish H. Vitamin D mitigates age-related cognitive decline through the modulation of pro-inflammatory state and decrease in amyloid burden[J]. J Neuroinflammation, 2012, 9(1): 244.DOI: 10.1186/1742-2094-9-244.
[40]	Zhang D, Li M, Dong Y, et al. 1α, 25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells[J]. Innate Immun, 2017, 23(7): 584-591.DOI: 10.1016/j.neulet.2012.08.071.