湖南省新型冠状病毒肺炎流行特征与临床特征

王斌; 耿娟; 张荣光; 昌帅磊; 陈帅印; 杨海燕; 郗园林; 段广才

doi:10.16462/j.cnki.zhjbkz.2020.07.016

湖南省新型冠状病毒肺炎流行特征与临床特征

doi: 10.16462/j.cnki.zhjbkz.2020.07.016

450001 郑州, 郑州大学公共卫生学院流行病学教研室

基金项目:

国家自然科学基金面上项目 81773495

详细信息

通讯作者:
张荣光, E-mail:zrg@zzu.edu.cn

中图分类号: R183
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- 被引次数: 0
出版历程
- 收稿日期: 2020-05-16
- 修回日期: 2020-06-05
- 刊出日期: 2020-07-10

Epidemiological and clinical characteristics of COVID-19 in Hunan Province

Department of Epidemiology, School of Public Health, Zhengzhou University, Zhengzhou 450001, China

Funds:

General Program of National Natural Science Foundation of China 81773495

More Information

Corresponding author: ZHANG Rong-guang, E-mail:zrg@zzu.edu.cn

摘要

摘要: 目的探讨湖南省新型冠状病毒肺炎（coronavirus disease 2019，COVID-19）的流行病学与临床特征。方法对确诊病例的流行病学和临床特征及其影响因素进行描述与分析。结果湖南省累计报告COVID-19确诊病例1 019例。从2020年1月21日确诊首例输入性病例至4月1日，病例的增长首先经历快速增长期，在2月中旬病例数趋于稳定，2月下旬至3月14日，为治愈病例数持续增长的消退期。前期病例以输入性病例为主，2月2日后本地病例新增数超过了输入性病例新增数。52.7%的病例临床首发症状为发热，但部分病例为腹泻恶心等消化道症状。聚集性病例代间距为5（2，9）d，一代病例中位潜伏期为7.5（5，11）d，二代病例中位潜伏期为10（7，14）d，各地市的累计发病率与对应城市的迁徙指数呈正相关，相关系数r=0.628（P=0.016）。结论湖南省COVID-19的总体疫情已经得到控制，但防控境外输入性病例的压力较大，且企业复工与学生复学增加了人员的流动性，近期疫情防控形势依然严峻。
- 新型冠状病毒肺炎 /
- 流行病学特征 /
- 临床特征
Abstract: Objective To investigate epidemiological and clinical characteristics of Coronavirus disease 2019 (COVID-19) in Hunan, China. Methods The epidemic data on COVID-19 in Hunan Province as of Apr 1th, 2020 were collected, and the epidemiological and clinical characteristics of the confirmed cases and influencing factors for this epidemic were described and analyzed. Results A total of 1 019 confirmed COVID-19 cases were reported in Hunan. Form the confirmation of the first imported case on Jan 21th to Apr 1th, 2020, the increase of cases first experienceed a period of rapid growth, and the early reported were mainly imported cases. The number of local new cases exceeded the number of imported new cases after Feb 2th. In the middle of February, the number of cases tended to be stable. The period from late Feb to 14th Mar was a regression period for the sustained increase in the number of cured cases. The first clinical symptom was fever in 52.7% of the cases, but some cases had gastrointestinal symptoms such as diarrhea and nausea. The gene-ration spacing of clustered cases was 5.0 (2, 9)days, the median incubation period of first-generation cases was 7.5 (5, 11) days, and the median incubation period of second-generation cases was 10.0 (7, 14) days. The cumulative incidence rate in each city was positively correlated with the migration index of the corresponding city, with the correlation coefficient r=0.628 (P=0.016). Conclusions The overall outbreak of COVID-19 in Hunan has been under control, but there is great pressure to prevent and control imported cases. Meanwhile, resuming work and study has increased the population migration, and the current situation of epidemic prevention and control is still severe.
- COVID-19 /
- Epidemiologic features /
- Clinical features

HTML全文

图 1 湖南省新冠肺炎时间分布

Figure 1. Time distribution of COVID-19 in Hunan Province

下载: 全尺寸图片幻灯片

图 2 湖南省COVID-19确诊病例数变化

Figure 2. Changes in the number of confirmed COVID-19 cases in Hunan Province

下载: 全尺寸图片幻灯片

图 3 湖南省COVID-19确诊病例地区分布

Figure 3. Regional distribution of confirmed COVID-19 cases in Hunan Province

下载: 全尺寸图片幻灯片

表 1 湖南省各地发病状况及可能影响因素

Table 1. Disease status and possible influencing factors in cities of Hunan Province

地区	确诊病例数 (例)	累计发病率 (/10万)	迁徙指数^a
长沙	242	3.31	4.12
岳阳	156	2.79	3.05
邵阳	102	1.41	3.45
常德	82	1.41	2.91
株洲	80	2.02	2.05
娄底	76	1.97	2.27
益阳	60	1.37	2.79
衡阳	48	0.66	3.51
永州	44	0.82	2.53
怀化	40	0.82	1.97
郴州	39	0.83	2.02
湘潭	36	1.28	1.82
湘西自治州	8	0.31	1.08
张家界	5	0.33	0.72
注：^a为武汉关闭离汉通道1天前迁徙指数，来自百度慧眼数据。

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参考文献(13)

[1]	Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019[J]. N Engl J Med, 2020, 382(8):727-733. DOI: 10.1056/NEJMoa2001017.
[2]	Lu R, Zhao X, Li J, et al. Genomic characterisation and epidemiology of 2019 novel coronavirus:implications for virus origins and receptor binding[J]. Lancet, 2020, 395(10224):565-574. DOI: 10.1016/S0140-6736(20)30251-8.
[3]	Phan LT, Nguyen TV, Luong QC, et al. Importation and human-to-human transmission of a novel coronavirus in Vietnam[J]. N Engl J Med, 2020, 382(9):872-874. DOI: 10.1056/NEJMc2001272.
[4]	Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China:a descriptive study[J]. Lancet, 2020, 395(10223):507-513. DOI: 10.1016/S0140-6736(20)30211-7.
[5]	WHO. Coronavirus disease 2019(COVID-19) situation report-83[EB/OL]. (2020-04-12)[2020-04-13]. https://www.who.int/docs/default-source/coronaviruse/situationreports/20200412-sitrep-83-covid-19.pdf?sfvrsn=697ce98d_4.
[6]	湖南省统计局.湖南省统计年鉴2019[EB/OL]. (2020-01-13)[2020-03-14]. http://222.240.193.190/19tjnj/indexch.htm. Hunan Provincial Bureau of Statistics. 2019 hunan statistical year book[EB/OL]. (2020-01-13)[2020-03-14]. http://222.240.193.190/19tjnj/indexch.htm.
[7]	国家卫生健康委办公厅.新型冠状病毒肺炎诊疗方案(试行第七版)[EB/OL]. (2020-03-04)[2020-03-14]. http://www.nhc.gov.cn/xcs/zhengcwj/202003/46c9294a7dfe4cef80dc7f5912eb1989/files/ce3e6945832a438eaae415350a8ce964.pdf. General Office of National Health Commission. National health commission diagnosis and treatment of COVID-19(trial version 7)[EB/OL]. (2020-03-04)[2020-03-14]. http://www.nhc.gov.cn/xcs/zhengcwj/202003/46c9294a7dfe4cef80dc7f5912eb1989/files/ce3e6945832a438eaae415350a8ce964.pdf.
[8]	胡建雄, 何冠豪, 刘涛, 等.新型冠状病毒肺炎疫情初期湖北省输出风险评估[J].中华预防医学杂志, 2020, 54(4):E017. DOI: 10.3760/cma.j.cn112150-20200219-00142. Hu JX, He GH, Liu T, et al. Risk assessment of exported risk of novel coronavirus pneumonia from Hubei Province[J]. Chin J Prev Med, 2020, 54(4):E017. DOI: 10.3760/cma.j.cn112150-20200219-00142.
[9]	Xu XW, Wu XX, Jiang XG, et al. Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China:retrospective case series[J]. BMJ, 2020, 368606. DOI: 10.1136/bmj.m606.
[10]	Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia[J]. N Engl J Med, 2020, 382(13):1199-1207. DOI: 10.1056/NEJMoa2001316.
[11]	董晓春, 李佳萌, 柏建芸, 等.天津市新型冠状病毒肺炎确诊病例流行病学特征分析[J].中华流行病学杂志, 2020, 41(5):638-642. DOI: 10.3760/cma.j.cn112338-20200221-00146. Dong XC, Li JM, Bai JY, et al. Epidemiological characteristics of confirmed COVID-19 cases in Tianjin[J]. Chin J Epidemiol, 2020, 41(5):638-642. DOI: 10.3760/cma.j.cn112338-20200221-00146.
[12]	苟发香, 张晓曙, 姚进喜, 等.甘肃省新型冠状病毒肺炎流行病学特征分析[J].中华流行病学杂志, 2020, 41:E032. DOI: 10.3760/cma.j.cn112338-20200229-00216. Gou FX, Zhang XS, Yao JX, et al. Epidemiological characteristics of COVID-19 in Gansu province[J]. Chin J Epidemiol, 2020, 41:E032. DOI: 10.3760/cma.j.cn112338-20200229-00216.
[13]	Zhang G, Zhang J, Wang B, et al. Analysis of clinical characteristics and laboratory findings of 95 cases of 2019 novel coronavirus pneumonia in Wuhan, China:a retrospective analysis[J]. Respir Res, 2020, 21(1):74. DOI: 10.1186/s12931-020-01338-8.