Analysis of epidemiological characteristics and trend prediction of influenza in Yinchuan City from 2009 to 2018
-
摘要:
目的 分析2009-2018年银川市流行性感冒(简称流感)的发病情况及流行病学特征,并预测发病趋势,为流感的防控提供科学依据。 方法 采用描述性研究的方法,描述2009-2018年银川市流感的流行病学特征,并用自回归移动平均混合模型(autoregressive integrated moving average model,ARIMA)预测2019年1月-2020年6月流感的发病趋势。 结果 2009-2018年银川市流感共报告2 254例,年均发病率为11.22/10万,整体呈下降趋势(χ2趋势=28.95,P < 0.001)。流感在秋冬季节高发,发病高峰为11月-次年1月。西夏区发病率最高(504例,18.34/10万),贺兰县最低(75例,3.59/10万)。男性发病率高于女性(11.86/10万vs10.56/10万,χ2=7.580,P < 0.001);流感在各年龄段均有分布,主要为0~5岁年龄段(528例,23.43%);以学生(776例,34.43%)、散居儿童(471例,20.90%)、农民(240例,10.65%)为主。ARIMA模型预测结果显示,2019年1月-2020年6月银川市流感发病率与2018年持平。 结论 2009-2018年银川市流感发病率整体呈下降趋势。西夏区为流感重点防控地区,学生、散居儿童、农民为易感人群,提示应更加关注易感人群的健康,加强对高发地区及5岁以下儿童流感的监测与管理。 Abstract:Objective To analyze the incidence and epidemiological characteristics of influenza in Yinchuan City from 2009 to 2018, and predict the incidence trend, so as to provide scientific evidence for prevention and control of influenza. Methods Descriptive study was used to describe the epidemiological characteristics of influenza in Yinchuan City from 2009 to 2018, and autoregressive integrated moving average model (ARIMA model) was used to forecast the incidence trend of influenza from January 2019 to June 2020. Results A total of 2 254 cases of influenza were reported in Yinchuan City from 2009 to 2018. The average annual incidence rate was 11.22/100 000. The incidence of influenza showed an overall downward trend (χ2Trend=28.95, P < 0.001). Influenza occurred most frequently in autumn and winter. The peak months were from November to January of the following year. The highest incidence region was Xixia district (504 cases, 18.34/100 000), and the lowest one was He Lan county (75 cases, 3.59/100 000). The incidence of influenza was higher in men than in women (11.86/100 000 vs 10.56/100 000, χ2=7.580, P < 0.001). It was distributed in all age groups. The main age rang was 0-5 years old (528 cases, 23.43%). Most cases were students (776 cases, 34.43%), scattered children (471 cases, 20.90%) and farmers (240 cases, 10.65%). The ARIMA model showed that the incidence of influenza in Yinchuan City from January 2019 to June 2020 was the same as that in 2018. Conclusions The incidence of influenza in Yinchuan City decreased from 2009 to 2018. Xixia district was the key prevention and control area of influenza. Students, scattered children and farmers were the vulnerable groups, which suggest that we should pay more attention to the health of vulnerable groups, strengthen surveillance and management of influenza in high-risk areas and children under the age of five. -
Key words:
- Influenza /
- Incidence /
- Epidemiological characteristics /
- Trend prediction
-
表 1 2009-2018年银川市流感发病率(/10万)
Table 1. Incidence of influenza in Yinchuan City from 2009 to 2018 (/ 100 000)
时间(年) 银川市 兴庆区 金凤区 西夏区 永宁县 贺兰县 灵武市 发病数 发病率 发病数 发病率 发病数 发病率 发病数 发病率 发病数 发病率 发病数 发病率 发病数 发病率 2009 547 34.78 136 32.28 158 59.38 54 28.65 151 70.43 17 8.59 31 10.89 2010 56 3.53 9 1.87 5 2.12 6 3.66 24 11.07 0 0.00 12 4.16 2011 76 3.81 15 2.21 7 2.13 5 1.77 22 10.08 2 0.90 25 9.55 2012 156 7.70 26 3.82 51 15.49 15 5.31 18 8.25 4 1.79 42 15.67 2013 223 10.73 93 13.14 36 10.48 43 14.59 15 6.59 5 2.15 31 11.36 2014 265 12.52 103 14.30 53 15.15 51 16.99 6 2.59 8 3.38 44 15.83 2015 218 10.18 56 7.69 58 16.41 86 28.35 5 2.13 7 2.92 6 2.14 2016 168 7.76 89 12.08 24 6.71 34 11.08 6 2.53 5 2.06 10 3.52 2017 219 10.00 66 8.85 76 21.00 52 16.74 5 2.08 8 3.26 12 4.17 2018 326 14.65 72 9.51 36 9.79 158 50.08 25 10.25 19 7.63 16 5.48 合计 2 254 11.22 665 9.99 504 15.30 504 18.34 277 12.13 75 3.59 229 8.18 表 2 2009-2018年银川市流感发病情况的年龄、性别分布(%)
Table 2. Age and gender distribution of influenza in Yinchuan City from 2009 to 2018 (%)
年龄分组
(岁)男 女 合计 发病数 构成比(%) 发病数 构成比(%) 发病数 构成比(%) 0~ 287 23.74 241 23.06 528 23.43 5~ 232 19.19 211 20.19 443 19.65 10~ 273 22.58 195 18.66 468 20.76 20~ 143 11.83 137 13.11 280 12.42 30~ 75 6.20 90 8.61 165 7.32 40~ 63 5.21 59 5.65 122 5.41 50~ 55 4.55 49 4.69 104 4.61 ≥60 81 6.70 63 6.03 144 6.39 合计 1 209 100.00 1 045 100.00 2 254 100.00 表 3 银川市2018年7月-2018年12月流感发病率预测值(/10万)
Table 3. The predicted incidence of influenza in Yinchuan City from July 2018 to December 2018 (/ 100 000)
时间(年-月) 实际值 预测值(95% CI) 误差 2018-07 0.40 0.47 (-1.84~2.78) -0.07 2018-08 0.31 0.61 (-2.51~3.72) -0.29 2018-09 0.40 0.65 (-2.56~3.86) -0.24 2018-10 0.63 0.64 (-2.58~3.87) -0.01 2018-11 0.54 1.67 (-1.56~4.89) -1.13 2018-12 1.66 2.90 (-0.33~6.12) -1.23 -
张瑾, 徐翮飞, 薛晓宁, 等. 2015-2017年度青岛口岸输入性流感监测分析[J].中国国境卫生检疫杂志, 2019, 42(4):246-250. DOI: 10.16408/j.1004-9770.2019.04.005.Zhang J, Xu HF, Xue XN, et al. Surveillance analysis of imported influenza in Qingdao port during 2015-2017[J]. Chinese Journal of Frontier Health and Quarantine, 2019, 42(4):246-250. DOI: 10.16408/j.1004-9770.2019.04.005. 张正, 高强, 苏琦, 等. 2014-2017年淮安市流感监测结果分析[J].现代预防医学, 2019, 46(18):3430-3434. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xdyfyx201918042Zhang Z, Gao Q, Su Q, et al. Analysis on influenza surveillance in Huai'an during 2014 to 2017[J]. Mod Prev Med, 2019, 46(18):3430-3434. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xdyfyx201918042 Burmaa A, Kamigaki T, Darmaa B, et al. Epidemiology and impact of influenza in Mongolia, 2007-2012[J]. Influenza Other Resp, 2014, 8(5):530-537. DOI: 10.1111/irv.12268. 王玲玲, 孙娇, 尤莉莉, 等. 2005-2015年中国流行性感冒发病率变化趋势分析[J].中国全科医学, 2019, 23(1):58-63. DOI:10.12114/j.issn.1007-9572.2019.725.Wang LL, Sun J, You LL, et al. Incidence trend of influenza in China from 2005 to 2015[J]. Chin Gen Pract, 2019, 23(1):58-63. DOI: 10.12114/j.issn.1007-9572.2019.725.issn.1007-9572.2019.725. 温秋芳, 孙晓强, 马学旻, 等. 2016-2018年宁夏流感监测结果分析[J].宁夏医学杂志, 2019, (10):1-5. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=nxyxzz201910008Wen QF, Sun XQ, Ma XM, et al. Analysis of influenza surveillance results during 2016-2018 in Ningxia[J]. Ningxia Medical Journal, 2019, (10):1-5. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=nxyxzz201910008 安洲, 程周祥, 钱帮群, 等. 2013-2015年芜湖市学校流感样病例暴发疫情的流行病学特征分析[J].现代预防医学, 2016, 43(22):4053-4056. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xdyfyx201622006An Z, Cheng ZX, Qian BQ, et al. Epidemiological characteristics of influenza-like illness outbreaks in schools of Wuhu from 2013 to 2015[J]. Mod Prev Med, 2016, 43(22):4053-4056. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xdyfyx201622006 马贵凤, 祝洁, 曹慧军, 等. 2013-2018年我国流感流行特征分析[J].中国病原生物学杂志, 2019, 14(1):73-77. DOI: 10.13350/j.cjpb.19011.Ma GF, Zhu J, Cao HJ, et al. Epidemiological analysis of influenza virus in China from 2013 to 2018[J]. Journal of Pathogen Biology, 2019, 14(1):73-77. DOI: 10.13350/j.cjpb.19011. 黄一伟, 张红, 刘运芝, 等. 2009年甲型H1N1流感研究进展[J].实用预防医学, 2009, 16(6):2011-2014. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=syyfyx200906138Huang YW, Zhang H, Liu YZ, et al. Progress of influenza a (H1N1) research in 2009[J]. Pract Prev Med, 2009, 16(6):2011-2014. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=syyfyx200906138 张耿林, 高志良.新发传染病及防控策略[J].中国病毒病杂志, 2018, 8(4):252-256. DOI: 10.16505/j.2095-0136.2018.0072.Zhang GL, Gao ZL. Emerging infectious disease and the strategy of prevention and control[J]. Chinese Journal of Viral Diseases, 2018, 8(4):252-256. DOI: 10.16505/j.2095-0136.2018.0072. 石平, 施超, 刘娟, 等. 2013-2017年无锡市流感年流感流行特征分析及预警值探讨[J].现代预防医学, 2019, 46(17):3096-3100. http://www.cnki.com.cn/Article/CJFDTotal-XDYF201917006.htmShi P, Shi C, Liu J, et al. Epidemiological analysis of seasonal influenza and threshold investigation for early warning, Wuxi, 2013-2017[J]. Mod Prev Med, 2019, 46(17):3096-3100. http://www.cnki.com.cn/Article/CJFDTotal-XDYF201917006.htm 雷明玉, 余春, 孙洁, 等. 2013-2017年贵州省流感暴发疫情特征分析[J].现代预防医学, 2019, 46(14):2511-2513. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xdyfyx201914005Lei MY, Yu C, Sun J, et al. Epidemiological analysis of influenza outbreaks in Guizhou from 2013 to 2017[J]. Mod Prev Med, 2019, 46(14):2511-2513. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xdyfyx201914005 孙彦峰, 赵秋剑, 胡侃, 等. 2010-2017年宝鸡市流感样病例病原学检测结果分析[J].现代预防医学, 2018, 45(8):1495-1498. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xdyfyx201808038Sun YF, Zhao QJ, Hu K, et al. Study on results of pathogenic detection of influenza-like illness cases in Baoji city[J]. Mod Prev Med, 2018, 45(8):1495-1498. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xdyfyx201808038 薛晓红, 宁海峰.银川市西夏区学校传染病防治管理现状与对策[J].现代预防医学, 2010, 37(16):3074-3075. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xdyfyx201016029Xue XH, Ning HF. Current situation and countermeasures for infectious disease management in schools of Xixia District of Yinchuan[J]. Mod Prev Med, 2010, 37(16):3074-3075. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xdyfyx201016029 王玲, 张艳, 曹海霞, 等. 2009-2015年淄博市流感样病例暴发疫情监测分析[J].中华疾病控制杂志, 2017, 21(2):206-208. DOI: 10.16462/j.cnki.zhjbkz.2017.02.024.Wang L, Zhang Y, Cao HX, et al. Epidemiological characteristics of influenza-like illness outbreak in Zibo City from 2009 to 2015[J]. Chin J Dis Control Prev, 2017, 21(2):206-208. DOI: 10.16462/j.cnki.zhjbkz.2017.02.024. Elhakim M, Hafiz Rasooly M, Fahim M, et al. Epidemiology of severe cases of influenza and other acute respiratory infections in the Eastern Mediterranean Region, July 2016 to June 2018[J]. J Infect Public Heal, 2019, 13(3):423-429. DOI: 10.1016/j.jiph.2019.06.009. 赵丹, 郝艳会.辽阳市流行性感冒流行特征分析[J].预防医学, 2019, 31(9):914-916. DOI: 10.19485/j.cnki.issn2096-5087.2019.09.013.Zhao D, Hao YH. Analysis of epidemic characteristics of influenza in liaoyang city[J]. Prev Med, 2019, 31(9):914-916. DOI: 10.19485/j.cnki.issn2096-5087.2019.09.013 Oliva J, Delgado-Sanz C, Larrauri A. Estimating the burden of seasonal influenza in Spain from surveillance of mild and severe influenza disease, 2010-2016[J]. Influenza Other Resp, 2018, 12(1):161-170. DOI: 10.1111/irv.12499. 孙树梅.关注儿童流感, 重视疫苗接种-AAP感染性疾病委员会《儿童流感的预防与控制建议(2018-2019年)》解读[J].中国全科医学, 2019, 22(6):621-626. DOI: 10.12114/j.issn.1007-9572.2019.00.010.Sun SM. Influenza in Children and Vaccination-Interpretation of AAP Committee on Infectious Diseases Recommendations for Prevention and Control of Influenza in Children(2018-2019)[J]. Chin Gen Pract, 2019, 22(6):621-626. DOI:10.12114/j.issn.1007-9572. 2019.00.010. Cunnin-Gham MJ, 李伟, 资海荣, 等. 2009-2013年南京市流感流行病学特征分析[J].中华疾病控制杂志, 2017, 21(1):3-7. DOI:10.16462/j.cnki.zhjbkz.2017. 01.001.Cunnin-Gham MJ, Li W, Zi HR, et al. Analysis of epidemiological characteristics of influenza in Nanjing from 2009 to 2013[J]. Chin J Dis Control Prev, 2017, 21(1):3-7. DOI: 10.16462/j.cnki.zhjbkz.2017.01.001. 邓斐, 资海荣, 余慧燕, 等.江苏省2010-2014年流感流行特征分析[J].中华疾病控制杂志, 2016, 20(9):901-904. DOI:10.16462/j.cnki. zhjbkz.2016.09.010.Deng F, Zi HR, Yu HY, et al. Epidemiology characteristic of influenza in Jiangsu Province, 2010-2014[J]. Chin J Dis Control Prev, 2016, 20(9):901-904. DOI: 10.16462/j.cnki.zhjbkz.2016.09.010. 温雯, 马建新, 黄立勇, 等. 2015-2016年北京市朝阳区流感流行特征及病原学分析[J].中华疾病控制杂志, 2017, 21(1):8-12. DOI:10.16462/j.cnki..zhjbkz.2017.01.002.zhjbkz.2017.01.002. Wen W, Ma JX, Huang LY, et al. Epidemiological analysis of surveillance for influenzain Chaoyang District, Beijing, 2015-2016[J]. Chin J Dis Control Prev, 2017, 21(1):8-12. DOI: 10.16462/j.cnki.zhjbkz.2017.01.002. 王璐璐, 孙海波, 孙佰红, 等.辽宁省2014-2017监测年度流感流行特征及变化趋势[J].中国公共卫生, 2019, 35(3):352-354. DOI: 10.11847/zgggws1120767.Wang LL, Sun HB, Sun BH, et al. Variation trend and prevalence characteristics of in fluenza in Liaoning Province, 2014-2017[J]. Chin J Public Heal, 2019, 35(3):352-354. DOI: 10.11847/zgggws1120767. 康敏, 谭小华, 杨宇威, 等.广东省2017-2018年冬季流感流行特征研究[J].中华流行病学杂志, 2018, 39(8):1071-1076. DOI: 10.3760/cma.j.issn.0254-6450.2018.08.011.Kang M, Tan XH, Yang YW, et al. Epidemioiogical characteristics of influenza in Guangdong Province, during winter of 2017-2018[J]. Chin J Epidemiol, 2018, 39(8):1071-1076. DOI: 10.3760/cma.j.issn.0254-6450.2018.08.011. 王园园, 陈伟, 李望晨, 等.基于ARIMA的传染病发病率趋势预测模型实证研究[J].中国城乡企业卫生, 2017, 32(11):6-9. DOI: 10.16286/j.1003-5052.2017.11.003.Wang YY, Chen W, Li WC, et al. Trend prediction modeling empirical research of infectious disease morbidity based on ARIMA[J]. Chinese Journal of Urban and Rural Enterprise Hygiene, 2017, 32(11):6-9. DOI: 10.16286/j.1003-5052.2017.11.003.