痴呆危险因素人群归因分值的城乡差异

张波; 张连生; 程桂荣; 曾燕; 安丽娜; 甘旭光; 吴玉莲; 刘丹

doi:10.16462/j.cnki.zhjbkz.2021.07.021

痴呆危险因素人群归因分值的城乡差异

doi: 10.16462/j.cnki.zhjbkz.2021.07.021

张波^{1, 2},
张连生¹,
程桂荣^{1, 2},
曾燕^{1, 2},
安丽娜^{1, 2},
甘旭光^{1, 2},
吴玉莲^{1, 2},
刘丹^{1, 2, ,}

1.
430065 武汉，武汉科技大学医学院
2.
430065 武汉，武汉科技大学脑科学先进技术研究院

基金项目:

国家自然科学基金 71774127

武汉科技大学人文社会科学高水平培育项目 W201809

详细信息

通讯作者:
刘丹，E-mail: 3123392758@qq.com

中图分类号: R181
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- 文章访问数: 378
- HTML全文浏览量: 271
- PDF下载量: 48
- 被引次数: 0
出版历程
- 收稿日期: 2020-07-14
- 修回日期: 2020-11-09
- 网络出版日期: 2021-08-13
- 刊出日期: 2021-07-10

Urban-rural differences in population attributable fractions for risk dementia factors

ZHANG Bo^{1, 2},
ZHANG Lian-sheng¹,
CHENG Gui-rong^{1, 2},
ZENG Yan^{1, 2},
AN Li-na^{1, 2},
Gan Xu-guang^{1, 2},
WU Yu-lian^{1, 2},
LIU Dan^{1, 2
, ,}

1.
Medical College, Wuhan University of Science and Technology, Wuhan 430065, China
2.
Brain Science and Advanced Technology Institute, Wuhan University of Science and Technology, Wuhan 430065, China

Funds:

National Natural Science Foundation of China 71774127

Key Program for Humanities and Social Sciences of Wuhan University of Science and Technology W201809

摘要

摘要: 目的使用人群归因分值(population attributable fractions, PAF)探讨痴呆危险因素所造成痴呆患者的比例，为今后痴呆的早期预防和干预提供建议。方法采用随机整群抽样的方法选取3 361名≥65岁的老年人进行调查，使用χ²检验分析危险因素的城乡差异。在主成分分析探索危险因素之间重叠效应的基础上，计算痴呆危险因素的加权PAF。结果城市痴呆危险因素的总加权PAF为39.51%，高血压、超重肥胖、吸烟、低教育程度、糖尿病、缺乏体育锻炼及缺乏社交的加权PAF分别为10.46%、9.78%、5.69%、5.55%、3.93%、2.75%及1.35%。农村痴呆危险因素的总加权PAF为31.66%，低教育程度、高血压、超重肥胖、缺乏社交、吸烟和糖尿病的加权PAF分别为9.21%、6.60%、4.96%、4.94%、4.44%和1.51%。结论不同危险因素的加权PAF在城乡之间存在较大差异，针对痴呆的预防策略和早期干预在城市及农村的侧重点应有所不同。
- 痴呆 /
- 人群归因分值 /
- 城乡差异
Abstract: Objective Based on the population attributable fraction (PAF), the ratio of dementia induced by risk factors was estimated to provide early prevention and intervention strategies. Methods To assess the urban-rural differences of risk factors of dementia using Chi-square test in 3 361 persons which are selected using random cluster sampling and 65 years or older. Based on the results from principal components analysis, we calculated the weighted PAF of each risk factor contributing to dementia. Results The overall weighted PAF for dementia risk factors in urban was 39.51%, and the weighted PAF for individual risk factors was hypertension (10.46%), overweight and obesity (9.78%), smoking (5.69%), low education (5.55%), diabetes (3.93%), lack of physical exercise (2.75%) and lack of social interaction (1.35%). The overall weighted PAF for dementia risk factors in rural was 31.66%, and the weighted PAF for individual risk factors was low education (9.21%), hypertension (6.60%), overweight and obesity (4.96%), lack of social interaction (4.94%), smoking (4.44%), diabetes (1.51%). Conclusions There was a significant difference in weighted PAF of each risk factor between urban and rural areas. And prevention and early intervention strategies for dementia should be given different emphasis in urban and rural areas.
- Dementia /
- Population attributable fractions /
- Urban-rural differences

HTML全文

表 1 痴呆危险因素的人群归因分值

Table 1. Population attributable fractions for dementia risk factors

危险因素	RR(95% CI)值	暴露情况(%)	重叠效应(%)	PAF(%)	加权PAF(%)
低教育程度	1.6(1.3~2.0)	49.42	77.63	22.87	6.43
高血压	1.6(1.2~2.2)	53.51	64.33	24.30	6.84
糖尿病	1.5(1.3~1.8)	16.45	42.25	7.60	2.14
超重肥胖	1.6(1.3~1.9)	43.83	47.77	20.82	5.86
吸烟	1.6(1.2~2.2)	28.65	96.23	14.67	4.13
缺乏社交	1.6(1.3~1.9)	22.64	74.71	11.96	3.37
总体加权PAF(%)					28.77

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表 2 痴呆危险因素的城乡分布[n(%)]

Table 2. The distribution for dementia risk factors in urban and rural areas [n(%)]

危险因素	城市		农村		χ²值	P值
危险因素	暴露人数	非暴露人数	暴露人数	非暴露人数	χ²值	P值
低教育程度	372(24.22)	1 536(75.78)	1 289(88.71)	164(11.29)	1 580.92	＜0.001
高血压	999(52.36)	909(47.64)	803(55.26)	650(44.74)	2.80	0.094
糖尿病	377(19.76)	1 531(80.24)	176(12.11)	1 277(87.89)	35.08	＜0.001
超重肥胖	915(47.96)	993(52.04)	558(38.40)	895(61.60)	30.57	＜0.001
吸烟	475(24.90)	1 433(75.10)	488(33.59)	965(66.41)	30.47	＜0.001
缺乏社交	206(10.80)	1 702(89.20)	555(38.20)	898(61.80)	353.56	＜0.001
缺乏体育锻炼	320(16.77)	1 588(83.23)

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表 3 痴呆危险因素人群归因分值的城乡差异

Table 3. Differences in population attributable fractions for dementia risk factors between urban and rural areas

危险因素	RR(95% CI)值	城市				农村
危险因素	RR(95% CI)值	暴露情况(%)	重叠效应(%)	PAF(%)	加权PAF(%)	暴露情况(%)	重叠效应(%)	PAF(%)	加权PAF(%)
低教育程度	1.6(1.3~2.0)	24.22	54.75	12.69	5.55	88.71	76.39	34.74	9.21
高血压	1.6(1.2~2.2)	52.36	55.83	23.91	10.46	55.26	55.49	24.90	6.60
糖尿病	1.5(1.3~1.8)	19.76	41.34	8.99	3.93	12.11	56.32	5.71	1.51
超重肥胖	1.6(1.3~1.9)	47.96	44.78	22.35	9.78	38.40	55.96	18.73	4.96
吸烟	1.6(1.2~2.2)	24.90	33.83	13.00	5.69	33.59	73.62	16.77	4.44
缺乏社交	1.6(1.3~1.9)	10.80	40.36	3.09	1.35	38.20	88.79	18.65	4.94
缺乏体育锻炼	1.4(1.2~1.7)	16.77	40.97	6.29	2.75
总体加权PAF(%)					39.51				31.66

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