深圳市学龄前儿童不同免疫接种方式对水痘抗体水平的影响

彭远舟; 李文豪; 张艳炜; 吴宇; 程锦泉

doi:10.16462/j.cnki.zhjbkz.2023.09.010

深圳市学龄前儿童不同免疫接种方式对水痘抗体水平的影响

doi: 10.16462/j.cnki.zhjbkz.2023.09.010

1.
暨南大学基础医学与公共卫生学院公共卫生与预防医学系，广州 510630
2.
深圳市疾病预防与控制中心学校卫生所，深圳 518038

基金项目:

广东省医学科学技术研究基金 A2020168

深圳市医学重点学科 SZXK064

详细信息

通讯作者:
程锦泉，E-mail: cjinquan@szcdc.net

中图分类号: R186.1
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- 被引次数: 0
出版历程
- 收稿日期: 2021-11-15
- 修回日期: 2022-03-09
- 网络出版日期: 2023-10-12
- 刊出日期: 2023-09-10

Effects of different immunization methods on varicella antibody levels in preschool children in Shenzhen City

1.
Department of Public Health and Preventive Medicine, School of Basic Medicine and Public Health, Jinan University, Guangzhou 510630, China
2.
School Health Center of Shenzhen Center for Disease Prevention and Control, Shenzhen 518038, China

Funds:

Medical Science and Technology Research Foundation of Guangdong Province A2020168

Shenzhen Key Medical Discipline SZXK064

More Information

Corresponding author: CHENG Jinquan, E-mail: cjinquan@szcdc.net

摘要

摘要: 目的评价深圳市学龄前儿童水痘抗体水平，为水痘疫苗免疫策略提供科学依据。方法采取分层随机抽样的方法，采集深圳市学龄前儿童血样，采用酶联免疫吸附测定(enzyme linked immuno sorbent assay, ELISA)测定血清中水痘抗体滴度，分析接种剂次、接种间隔等不同免疫状态对水痘IgG抗体几何平均浓度(geometric mean concentration, GMC)、抗体阳性率的影响。结果深圳市学龄前儿童水痘IgG抗体GMC为11.20 U/mL，阳性率为61.5%。未接种组、接种1次组和接种2次组的GMC分别为4.31 U/mL、12.15 U/mL、15.86 U/mL(F=11.11, P < 0.001)，抗体阳性率分别为26.1%、39.5%和74.5%(χ²=41.42, P < 0.001);第1针及时接种组和超期接种组GMC分别为14.17 U/mL、8.07 U/mL(t=3.11, P=0.002)，抗体阳性率分别为70.8%、47.9%(χ²=11.12, P < 0.001)。结论深圳市学龄前儿童及时地完成第2针疫苗接种可提高免疫抗体水平。
- 水痘 /
- 学龄前儿童 /
- 免疫状态 /
- 免疫程序 /
- 加强免疫
Abstract: Objective To evaluate the level of varicella antibody in preschool children in Shenzhen, and to provide a scientific basis for effective varicella vaccine immunization strategy. Methods Blood samples were collected from preschool children in Shenzhen through stratified random sampling. The varicella antibody titer in the serum was measured using an enzyme-linked immunosorbent assay. The influence of different immunization conditions, such as the number of vaccinations and the interval between vaccinations, on the geometric mean concentration (GMC) and positive rate of varicella IgG antibody was analyzed. Results The GMC of chickenpox IgG antibody in preschool children in Shenzhen was 11.20 U/ml, and the positive rate of chickenpox IgG antibody was 61.5%. The GMC of chickenpox IgG antibody in non-vaccinated group, once vaccinated group and twice vaccinated group were 4.31 U/ml, 12.15 U/ml and 15.86 U/ml, respectively (F=11.11, P < 0.001). And the positive rate of chickenpox IgG antibody was 26.1%, 39.5% and 74.5% in these groups, respectively(χ²= 41.42, P < 0.001); The GMC of chickenpox IgG antibody in the first needle timely vaccination group and extended vaccination group were 14.17 U/ml and 8.07 U/ml, respectively (t=3.11, P=0.002), with positive rate of 70.8% and 47.9%, respectively(χ²=11.12, P < 0.001). Conclusions Timely completion of the second vaccination for preschool children in Shenzhen can improve the antibody levels.
- Varicella /
- Preschool children /
- Immune state /
- Immunization program /
- Strengthen the immune

HTML全文

表 1 深圳市学龄前儿童水痘IgG抗体水平的总体情况

Table 1. General situation of chickenpox IgG antibody levels in preschool children in Shenzhen City

类别 Category	人数 Number ofpeople	阳性数 Number ofpositives	阳性率/% Positive rate/%	GMC/(U·mL^-1)	t/χ²/F值value	P值 value
性别Gender
男Male	149	99	66.4	12.44	1.34	0.182
女Female	142	80	56.3	10.03	2.72	0.099
年龄组/岁Age group/years
4	112	68	60.7	10.78
5	112	69	61.6	11.42	0.07	0.932
6	67	42	62.6	11.54	0.07	0.965
地区District
南山区Nanshan	97	60	61.8	11.33
罗湖区Luohu	95	56	58.9	11.39	0.03	0.969
宝安区Bao′an	99	63	63.6	10.89	0.45	0.796
合计Total	291	179	61.5	11.20
注：GMC, 几何平均浓度。 Note: GMC, geometric mean concentration.

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表 2 深圳市学龄前儿童水痘疫苗免疫状态分布

Table 2. Distribution of immunization status of varicella vaccine among preschool children in Shenzhen City

类别 Category	人数 Number ofpeople	阳性数 Number ofpositives	阳性率/% Positive rate/%	GMC/(U·mL^-1)	t/χ²/F值value	P值value
接种剂次Number of inoculations
未接种组Non-vaccinated group	23	6	26.1	4.31
接种1次组once vaccinated group	76	30	39.5	12.15	11.11	< 0.001
接种2次组twice vaccinated group	192	143	74.5	15.86	41.42	< 0.001
第1针是否及时接种Get the first dose inoculation in time
是Yes	195	138	70.8	14.17	3.11	0.002
否No	73	35	47.9	8.07	11.12	< 0.001
第2针是否及时接种Get the second dose inoculation in time
是Yes	178	133	74.7	15.47	-0.82	0.426
否No	12	10	71.4	21.86		0.733
2针接种间隔时间/月Interval between two shots/months
< 12	15	8	53.3	8.73
12~ < 24	20	12	60.0	13.08
24~ < 36	42	35	83.3	17.65	1.30	0.273
36~ < 48	97	74	76.2	16.73		0.107
≥48	18	14	77.7	18.89
末次接种后的时间/月Time since last inoculation/months
< 12	146	104	71.2	15.23
12~ < 24	45	33	73.3	14.52
24~ < 36	20	9	45.0	6.65	3.77	0.005
36~ < 48	19	8	42.1	6.55	1.33	0.185
≥48	20	11	55.0	11.00
注：GMC, 几何平均浓度。 Note: GMC, geometric mean concentration.

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