miRNA作为尘肺病潜在生物标志物的研究与进展

杜苗苗; 王佳; 李雯雯; 穆敏; 朱峰林; 叶冬青

doi:10.16462/j.cnki.zhjbkz.2023.12.019

miRNA作为尘肺病潜在生物标志物的研究与进展

doi: 10.16462/j.cnki.zhjbkz.2023.12.019

杜苗苗¹,
王佳^{1, 2, 3, ,},
李雯雯³,
穆敏³,
朱峰林^{2, 3},
叶冬青^{1, 3, ,}

1.
安徽理工大学工业粉尘防控与职业安全健康教育部重点实验室，淮南 232000
2.
安徽理工大学煤炭安全开采国家地方联合工程研究中心，淮南 232000
3.
安徽理工大学公共卫生学院，淮南 232000

基金项目:

工业粉尘防控与职业安全健康教育部重点实验室开放基金 EK20202002

煤炭安全精准开采国家地方联合工程研究中心开放基金 EC2021007

安徽理工大学引进人才基金 13200389

详细信息

通讯作者:
叶冬青，E-mail: ydqph@aust.edu.cn

王佳，E-mail: wangjia@whu.edu.cn

中图分类号: R135.2
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- 文章访问数: 211
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- PDF下载量: 21
- 被引次数: 0
出版历程
- 收稿日期: 2023-06-28
- 修回日期: 2023-10-04
- 刊出日期: 2023-12-10

Research and progress of miRNA as potential biomarkers for pneumoconiosis

DU Miaomiao¹,
WANG Jia^{1, 2, 3
, ,},
LI Wenwen³,
MU Min³,
ZHU Fenglin^{2, 3},
YE Dongqing^{1, 3
, ,}

1.
Key Laboratory of Industrial Dust Prevention and Control, Occupational Safety and Health, Ministry of Education, Anhui University of Science and Technology, Huainan 232000, China
2.
Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining, Anhui University of Science and Technology, Huainan 232000, China
3.
School of Public Health, Anhui University of Science and Technology, Huainan 232000, China

Funds:

Independent Research Fund of Key Laboratory of Industrial Dust Prevention and Control & Occupational Health and Safety, Ministry of Education EK20202002

The Open Research Grant of the Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining EC2021007

Scientific Research Foundation for High-level Talents of Anhui University of Science and Technology 13200389

More Information

Corresponding author: WANG Jia, E-mail: wangjia@whu.edu.cn; YE Dongqing, E-mail: ydqph@aust.edu.cn

摘要

摘要: 尘肺病是目前我国临床上最常见的职业病之一，其发病机制尚未完全明确，临床上缺乏有效地治疗方法。微小RNA(microRNAs, miRNA)是一类非编码单链的RNA分子，通过与靶基因结合，抑制mRNA翻译或促进mRNA的降解，以此参与基因转录后翻译水平的调控。已有研究表明miRNA与尘肺病的发生发展密切相关，是尘肺病早期筛查诊断的重要候选生物标志物。本研究就miRNA在尘肺病中的研究现状和进展进行综述，为尘肺病的发病机制研究及早期预警、诊断、治疗提供新的思路及方法。
- 微小RNA /
- 尘肺病 /
- 生物标志物
Abstract: Pneumoconiosis is one of the most common occupational diseases in China, which has a very complex pathogenesis and lacks effective treatment in clinical practice. MicroRNAs (miRNAs) are a class of non-coding single-stranded RNA molecules that participate in the regulation of post-transcriptional translation by binding to target genes and inhibiting mRNA translation or promoting mRNA degradation. Previous studies have shown that miRNA is closely related to the occurrence and development of pneumoconiosis, which considered to be an important candidate biomarker for early screening and diagnosis for pneumoconiosis. This artide summarizes the current status of miRNA in pneumoconiosis, aiming to provide new ideas and methods for the study of pathogenesis, early warning, diagnosis and treatment of pneumoconiosis.
- miRNA /
- Pneumoconiosis /
- Biomarker

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图 1 尘肺病发病机制示意

Figure 1. Schematic diagram of pathogenic mechanism of pneumoconiosis

下载: 全尺寸图片幻灯片

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