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血尿酸水平与血脂异常关系的交叉滞后分析

尹田秀 朱晓玥 何志亮 白鹤翔 沈辰也 蔡乐 李若愚 王蓓

尹田秀, 朱晓玥, 何志亮, 白鹤翔, 沈辰也, 蔡乐, 李若愚, 王蓓. 血尿酸水平与血脂异常关系的交叉滞后分析[J]. 中华疾病控制杂志, 2024, 28(1): 14-19. doi: 10.16462/j.cnki.zhjbkz.2024.01.003
引用本文: 尹田秀, 朱晓玥, 何志亮, 白鹤翔, 沈辰也, 蔡乐, 李若愚, 王蓓. 血尿酸水平与血脂异常关系的交叉滞后分析[J]. 中华疾病控制杂志, 2024, 28(1): 14-19. doi: 10.16462/j.cnki.zhjbkz.2024.01.003
YIN Tianxiu, ZHU Xiaoyue, HE Zhiliang, BAI Hexiang, SHEN Chenye, CAI Le, LI Ruoyu, WANG Bei. Cross-lagged analysis of the relationship between serum uric acid and dyslipidemia[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(1): 14-19. doi: 10.16462/j.cnki.zhjbkz.2024.01.003
Citation: YIN Tianxiu, ZHU Xiaoyue, HE Zhiliang, BAI Hexiang, SHEN Chenye, CAI Le, LI Ruoyu, WANG Bei. Cross-lagged analysis of the relationship between serum uric acid and dyslipidemia[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(1): 14-19. doi: 10.16462/j.cnki.zhjbkz.2024.01.003

血尿酸水平与血脂异常关系的交叉滞后分析

doi: 10.16462/j.cnki.zhjbkz.2024.01.003
基金项目: 

重大慢性非传染性疾病防控研究专项 2016YFC1305700

详细信息
    通讯作者:

    王蓓,E-mail:wangbeilxb@163.com

  • 中图分类号: R181.3

Cross-lagged analysis of the relationship between serum uric acid and dyslipidemia

Funds: 

Special Research Project on Prevention and Control of Major Chronic Noncommunicable Diseases on Early Identification of Risk Factors, Early Diagnosis Technology and Pointcut of Diabetes 2016YFC1305700

More Information
  • 摘要:   目的  研究血尿酸(serum uric acid, SUA)水平升高与血脂质之间的关系,为预防控制血脂异常和高尿酸血症提供依据。  方法  2017年4—7月在江苏省盐城市盐都区,采用多级分层随机抽样方法,对≥18岁常住居民进行基线调查,于2022年对该队列人群进行随访;采用交叉滞后模型,探讨SUA水平与血脂之间的关系,包括总胆固醇(total cholesterol, TC)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol, LDL-C)、三酰甘油(triglyceride, TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol, HDL-C),并且针对性别进行分层分析,探究SUA水平与血脂异常的关系是否存在性别差异。  结果  共有1 347名符合条件的对象纳入研究。基线TC到随访SUA的路径系数在一般人群(β=3.402, P=0.048)和男性(β=7.214,P=0.012)中差异均有统计学意义;基线SUA到随访TC的路径系数差异无统计学意义(P=0.958)。基线TG到随访SUA的路径系数在一般人群(β=2.357, P=0.011)和男性(β=3.425,P=0.011)中差异均有统计学意义;基线SUA到随访TG的路径系数差异无统计学意义(P=0.188)。基线SUA到随访HDL-C的路径系数在一般人群(β=0.002,P<0.001)、男性(β=0.001,P<0.001)和女性(β=0.003,P<0.001)中差异均有统计学意义;基线HDL-C到随访SUA的路径系数差异无统计学意义(P=0.461)。基线SUA到随访LDL-C的路径系数在一般人群(β=0.002, P<0.001)、男性(β=0.004,P<0.001)和女性(β=0.001,P=0.015)中差异均有统计学意义;基线LDL-C到随访SUA的路径系数差异无统计学意义(P=0.436)。  结论  SUA与血脂水平之间相互影响,TC、TG水平升高可能导致SUA水平升高,从而可能导致LDL-C水平升高和HDL-C水平降低。
  • 图  1  SUA与TC水平的交叉滞后分析

    SUA:血尿酸;TC:总胆固醇。
    a: P<0.05。

    Figure  1.  Cross-lagged analysis of SUA and TC

    SUA: surem uric acid; TC: total cholesterol.
    a: P < 0.05.

    图  2  SUA与TG水平的交叉滞后分析

    SUA:血尿酸;TG:三酰甘油。
    a: P<0.05。

    Figure  2.  Cross-lagged analysis of SUA and TG

    SUA: surem uric acid; TG: triglyceride.
    a: P < 0.05.

    图  3  SUA与HDL-C水平的交叉滞后分析

    SUA:血尿酸;HDL-C:高密度脂蛋白胆固醇。
    a: P<0.05。

    Figure  3.  Cross-lagged analysis of SUA and HDL-C

    SUA: surem uric acid; HDL-C: high-density lipoprotein cholesterol
    a: P < 0.05.

    图  4  SUA与LDL-C水平的交叉滞后分析

    SUA:血尿酸;LDL-C:低密度脂蛋白胆固醇。
    a: P<0.05。

    Figure  4.  Cross-lagged analysis of SUA and LDL-C

    SUA: surem uric acid; LDL-C: low-density lipoprotein cholesterol.
    a: P < 0.05.

    图  5  SUA与TC水平的交叉滞后分析(分层分析)

    SUA:血尿酸;TC:总胆固醇。
    a: P<0.05。

    Figure  5.  Cross-lagged analysis of SUA and TC (stratified analysis)

    SUA: surem uric acid; TC: total cholesterol.
    a: P < 0.05.

    图  6  SUA与TG水平的交叉滞后分析(分层分析)

    SUA:血尿酸;TG:三酰甘油。
    a: P<0.05。

    Figure  6.  Cross-lagged analysis of SUA and TG (stratified analysis)

    SUA: surem uric acid; TG: triglyceride.
    a: P < 0.05.

    图  7  SUA与HDL-C水平的交叉滞后分析(分层分析)

    SUA:血尿酸;HDL-C:高密度脂蛋白胆固醇。
    a: P<0.05。

    Figure  7.  Cross-lagged analysis of SUA and HDL-C (stratified analysis)

    SUA: surem uric acid; HDL-C: high-density lipoprotein cholesterol.
    a: P < 0.05.

    图  8  SUA与LDL-C水平的交叉滞后分析(分层分析)

    SUA:血尿酸;LDL-C:低密度脂蛋白胆固醇。
    a: P<0.05。

    Figure  8.  Cross-lagged analysis of SUA and LDL-C (stratified analysis)

    SUA: surem uric acid; LDL-C: low-density lipoprotein cholesterol.
    a: P < 0.05.

    表  1  交叉滞后分析中受试者的基线特征

    Table  1.   Baseline characteristics of subjects in cross-lagged analysis

    变量Variable 合计 Total (n=1 347) 男性 Male (n=543) 女性 Female (n=804) Z/χ2值value P值value
    年龄/岁Age/years 52.0(47.0, 60.0) 53.0(46.0, 61.0) 52.0(47.0, 60.0) 1.739 0.207
    BMI/(kg·m-2) 25.3(23.2, 27.7) 25.5(23.2, 28.0) 25.3(23.2, 27.6) 0.554 0.554
    SBP/mmHg-1 135.0(124.0, 148.0) 138.0(126.0, 150.8) 133.0(122.0, 147.0) 8.835 0.003
    DBP/mmHg-1 85.0(77.0, 92.0) 86.0(79.0, 93.0) 83.5(76.0, 90.0) 16.429 0.001
    TG/(mmol·L-1) 1.4(1.0, 2.1) 1.5(1.0, 2.2) 1.3(0.9, 1.9) 9.748 0.002
    TC/(mmol·L-1) 4.8(4.2, 5.4) 4.7(4.2, 5.3) 4.9(4.2, 5.5) 8.536 0.003
    HDL-C/(mmol·L-1) 1.5(1.3, 1.8) 1.5(1.2, 1.7) 1.6(1.3, 1.8) 22.259 0.001
    LDL-C/(mmol·L-1) 2.6(2.2, 3.1) 2.6(2.1, 3.0) 2.6(2.2, 3.1) 0.977 0.323
    FPG/(mmol·L-1) 5.7(5.3, 6.1) 5.8(5.4, 6.3) 5.6(5.3, 6.1) 16.276 0.001
    HbA1c/ % 5.3(5.0, 5.6) 5.3(5.0, 5.6) 5.3(5.0, 5.6) 0.112 0.738
    SUA/(mmol·L-1) 293.0(241.0, 349.0) 345.0(298.0, 398.5) 260.0(222.0, 307.0) 269.242 0.001
    吸烟Smoking 289(21.5) 268(49.4) 21(2.6) 420.225 0.001
    饮酒Drinking 280(20.8) 237(43.6) 43(5.3) 288.707 0.001
    规律运动Regular exercise 375(27.8) 169(31.1) 206(25.6) 4.883 0.027
    注:TG, 三酰甘油; TC, 总胆固醇; HDL-C, 高密度脂蛋白胆固醇; LDL-C, 低密度脂蛋白胆固醇; FPG, 空腹血糖; HbA1c, 糖化血红蛋白; SUA, 血尿酸。
    ①以M(P25, P75)或人数(占比/%)表示。
    Note: TG, triglyceride; TC, total cholesterol; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; FPG, fasting plasma glucose; HbA1c, glycosylated hemoglobin; SUA, serum uric acid.
    M(P25, P75) or number of people (proportion/%).
    下载: 导出CSV
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  • 收稿日期:  2023-05-10
  • 修回日期:  2023-09-30
  • 网络出版日期:  2024-02-05
  • 刊出日期:  2024-01-10

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