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HPV E2、E5致癌机制及相关疫苗研究进展

崔湘杰 史荔 陶玉芬

崔湘杰, 史荔, 陶玉芬. HPV E2、E5致癌机制及相关疫苗研究进展[J]. 中华疾病控制杂志, 2024, 28(1): 96-100. doi: 10.16462/j.cnki.zhjbkz.2024.01.015
引用本文: 崔湘杰, 史荔, 陶玉芬. HPV E2、E5致癌机制及相关疫苗研究进展[J]. 中华疾病控制杂志, 2024, 28(1): 96-100. doi: 10.16462/j.cnki.zhjbkz.2024.01.015
CUI Xiangjie, SHI Li, TAO Yufen. Research progress in the study of HPV E2, E5 oncogenic mechanism and related vaccine[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(1): 96-100. doi: 10.16462/j.cnki.zhjbkz.2024.01.015
Citation: CUI Xiangjie, SHI Li, TAO Yufen. Research progress in the study of HPV E2, E5 oncogenic mechanism and related vaccine[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2024, 28(1): 96-100. doi: 10.16462/j.cnki.zhjbkz.2024.01.015

HPV E2、E5致癌机制及相关疫苗研究进展

doi: 10.16462/j.cnki.zhjbkz.2024.01.015
基金项目: 

云南省重大科技专项计划 202002AA100009

中国医学科学院医学与健康科技创新工程项目 2021-I2M-1-004

详细信息
    通讯作者:

    陶玉芬,E-mail:taoyufen@imbcams.com.cn

  • 中图分类号: R737.33

Research progress in the study of HPV E2, E5 oncogenic mechanism and related vaccine

Funds: 

Major Science and Technology Projects of Yunnan Provincial 202002AA100009

Chinese Academy of Medical Sciences Innovation Fund for Medical Science 2021-I2M-1-004

More Information
  • 摘要: 宫颈癌是影响女性的常见恶性肿瘤之一,其中高危型HPV的持续感染是导致宫颈癌的主要病因。在宫颈癌的发生发展过程中,除了HPV E6、E7与宫颈癌病变有主要的关系外,其他一些早期蛋白如E2、E5也发挥了重要的作用。如E2可以启动并维持病毒的复制,而E5可以与E6、E7癌蛋白合作,促进感染细胞增殖。本研究仅就HPV E2、E5在宫颈癌发生发展中的机制以及相关的治疗性疫苗研究进展进行综述。
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出版历程
  • 收稿日期:  2023-06-21
  • 修回日期:  2023-08-31
  • 网络出版日期:  2024-02-05
  • 刊出日期:  2024-01-10

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