安徽省2013—2022年戊型病毒性肝炎流行病学特征分析

王阿鑫; 肖永康; 毕念念; 龚磊; 吴家兵

doi:10.16462/j.cnki.zhjbkz.2024.06.005

安徽省2013—2022年戊型病毒性肝炎流行病学特征分析

doi: 10.16462/j.cnki.zhjbkz.2024.06.005

王阿鑫¹,
肖永康²,
毕念念²,
龚磊²,
吴家兵^{1, 2, ,}

1.
蚌埠医科大学公共卫生学院，蚌埠 233000
2.
安徽省疾病预防控制中心卫生应急管理与急性传染病防治科，合肥 230601

基金项目:

中联肝健康促进中心，中国戊型肝炎防治专项基金课题 CLH2023-F-HEV-09

详细信息

通讯作者:
吴家兵，E-mail: wjb0386@126.com

中图分类号: R512.6
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- 文章访问数: 100
- HTML全文浏览量: 24
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- 被引次数: 0
出版历程
- 收稿日期: 2023-08-23
- 修回日期: 2024-03-15
- 网络出版日期: 2024-07-13
- 刊出日期: 2024-06-10

Epidemiological analysis on hepatitis E in Anhui Province from 2013 to 2022

1.
School of Public Health, Bengbu Medical College, Bengbu 233000, China
2.
Anhui Provincial Center for Disease Control and Prevention Department of Health Emergency Management and Prevention of Acute Infectious Diseases, Hefei 230601, China

Funds:

China Liver Health China Hepatitis E Prevention and Control Special Fund Project CLH2023-F-HEV-09

More Information

Corresponding author: WU Jiabing, E-mail: wjb0386@126.com

摘要

摘要: 目的分析安徽省2013—2022年戊型病毒性肝炎(viral hepatitis E, HE)的流行病学特征，为预防和控制HE提供科学依据。方法通过中国疾病预防控制信息系统传染病报告系统收集2013—2022年安徽省HE病例报告信息，描述性分析HE病例的流行特征，并采用Joinpoint回归分析HE报告发病率的时间变化趋势。结果 2013—2022年安徽省共报告HE病例15 465例，年均报告发病率为2.52/10万。经Joinpoint回归模型分析，2013—2022年HE年均报告发病率呈现2个阶段波动，以2020年为拐点，在2013—2020年呈下降趋势，年度变化百分比(annual percent change, APC)为-6.86%(P=0.005)，2020—2022年呈上升趋势，APC为18.33%(P=0.183)。在病例三间分布上，1—4月共报告病例6 663例，占比最高(43.08%)；安徽省16个市均有病例报告，年平均报告发病率居前3位的地区分别为蚌埠市(6.70/10万)、淮南市(6.28/10万)和宿州市(4.75/10万)，地区间报告发病率差异有统计学意义(χ²=6 792.45，P＜0.001)；病例中男性多于女性，男女性别比为2.53∶1.00；病例以中老年人为主(60.7%)，年龄集中在45~＜70岁；职业以农民为主，占61.05%。结论安徽省2013—2022年HE年均报告发病率呈整体下降趋势，2020—2022年有所回升，HE整体防控工作仍不容忽视。应围绕中老年人、农民等重点人群积极开展HE科普宣传，在高发季节加强HE的健康干预和防治工作。
- 戊型病毒性肝炎 /
- 流行特征 /
- 流行趋势
Abstract: Objective To analyze the epidemiological characteristics of viral hepatitis E (HE) in Anhui Province from 2013 to 2022, providing a scientific basis for the prevention and control of HE. Methods HE case report information in Anhui Province from 2013 to 2022 were collected through the Chinese Center for Disease Control and Prevention Information System for Infectious Disease Reporting. A descriptive analysis of the epidemic characteristics of HEE cases was conducted, and Joinpoint regression analyswas was used to study the temporal trends in the reported incidence of HE. Results Between 2013 and 2022, a total of 15 465 cases of HE were reported in Anhui Province, with an average annual reported incidence rate of 2.52 per 100 000. According to the Joinpoint regression model analysis, the average annual reported incidence rate of HE showed two-phase fluctuations during 2013-2022, with a turning point in 2020. From 2013 to 2020, there was a decreasing trend with an annual percent change (APC) of -6.86% (P=0.005), while from 2020 to 2022, there was a rebound with an APC of 18.33% (P=0.183). In terms of the distribution of cases, a total of 6 663 cases were reported from January to April, accounting for the highest proportion (43.08%); cases were reported in all 16 cities in Anhui Province, with the top three annual average reported incidence rates being in Bengbu City (6.70 per 100 000), Huainan City (6.28 per 100 000), and Suzhou City (4.75 per 100 000), and there was a statistically significant difference in reported incidence rates among regions (χ²= 6 792.45, P < 0.001); there were more male cases than female cases, with a male-to-female ratio of 2.53∶1.00; cases were mainly in middle-aged and elderly people, with 60.7% of cases concentrated in the 45-< 70 age group; the main occupation was farmers, accounting for 61.05%. Conclusions The average annual reported incidence rate of HEin Anhui Province shows an overall fluctuating downward trend from 2013 to 2022, but there has been a slight increase in the past two years. The overall prevention and control of HE should not be underestimated. In the future, HE popularization should be actively carried out in key groups such as middle-aged and elderly people and farmers. Strengthening health interventions and prevention and control efforts for HE during the high-incidence seasons is also crucial.
- Viral hepatitis E /
- Epidemiological characteristics /
- Epidemic trend

HTML全文

图 1 安徽省2013—2022年戊型病毒性肝炎报告发病率变化趋势的Joinpoint回归分析

Observed：观察到的发病率；APC：年度变化百分比。

Figure 1. Joinpoint regression analysis of the trend of reported incidence of viral hepatitis E in Anhui Province from 2013 to 2022

Observed: observed incidence; APC: annual percentage change.

下载: 全尺寸图片幻灯片

图 2 安徽省2013—2022年戊型病毒性肝炎发病月份报告情况

Figure 2. Monthly reported incidence of viral hepatitis E in Anhui Province from 2013 to 2022

下载: 全尺寸图片幻灯片

图 3 安徽省2013—2022年戊型病毒性肝炎报告发病年龄分布

Figure 3. Age distribution of reported viral hepatitis E in Anhui Province from 2013 to 2022

下载: 全尺寸图片幻灯片

表 1 安徽省2013—2022年戊型病毒性肝炎报告发病地区分布情况

Table 1. Regional distribution of viral hepatitis E reported incidence in Anhui Province from 2013 to 2022

地市City	病例报告数 Number of case reports	报告发病率/10万^-1 Reported incidence /100 000^-1
宿州市Suzhou City	2 612	4.75
蚌埠市Bengbu City	2 243	6.70
合肥市Hefei City	1 819	2.23
淮南市Huainan City	1 812	6.28
滁州市Chuzhou City	1 182	2.95
阜阳市Fuyang City	1 156	1.44
六安市Lu′an City	785	1.58
安庆市Anqing City	735	1.54
亳州市Bozhou City	617	1.22
芜湖市Wuhu City	498	1.34
宣城市Xuancheng City	491	1.91
黄山市Huangshan City	475	3.48
淮北市Huaibei City	378	1.77
马鞍山市Ma′anshan City	271	1.21
池州市Chizhou City	255	1.80
铜陵市Tongling City	136	1.05

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参考文献(16)

[1]	杨仕贵. 消除病毒性肝炎公共卫生威胁, 机遇与挑战并存[J]. 中华疾病控制杂志, 2021, 25(7): 749-752. DOI: 10.16462/j.cnki.zhjbkz.2021.07.002. Yang SG. Eliminating the public health threat of viral hepatitis, both opportunities and challenges exist[J]. Chin J Dis Control Prev, 2021, 25(7): 749-752. DOI: 10.16462/j.cnki.zhjbkz.2021.07.002.
[2]	董邓波, 邹圣强, 唐舒. 2009—2019年中国病毒型肝炎发病的时空流行病学特征分析[J]. 现代预防医学, 2024, 51(4): 595-601. DOI: 10.20043/j.cnki.MPM.202311272. Dong DB, Zou SQ, Tang S. Spatio-temporal epidemiological characterization of viral hepatitis incidence in China from 2009-2019[J]. Modern Preventive Medicine, 2024, 51(4): 595-601. DOI: 10.20043/j.cnki.MPM.202311272.
[3]	王葳, 陈恺韵, 吴立梦, 等. 2017-2020年上海市戊型肝炎病毒基因型特征研究[J]. 疾病监测, 2022, 37(2): 214-219. https://www.cnki.com.cn/Article/CJFDTOTAL-JBJC202202017.htm Wang W, Cheng KY, Wu LM, et al. Genotypic characterization of hepatitis E virus in Shanghai, 2017-2020[J]. Dis Surveill, 2022, 37(2): 214-219. https://www.cnki.com.cn/Article/CJFDTOTAL-JBJC202202017.htm
[4]	北京大学人民医院, 北京大学肝病研究所, 中国药品生物制品检定所, 等. 戊型病毒性肝炎诊断标准[S]. 行业标准-卫生, 2008: 1-7. People's Hospital of Peking University, Institute of Liver Diseases of Peking University, China National Institute for the Control of Pharmaceutical and Biological Products, et al. Diagnostic criteria for viral hepatitis E[S]. Industry Standard-Health, 2008: 1-7.
[5]	黄澳迪, 唐林, 王晓琪, 等. 中国2011-2021年戊型病毒性肝炎发病趋势和时空聚集性[J]. 中国疫苗和免疫, 2022, 28(4): 417-421. DOI: 10.19914/j.CJVI.2022080. Huang AD, Tang L, Wang XQ, et al. Trends and spatial and temporal aggregation of viral hepatitis E incidence in China, 2011-2021[J]. Chinese Journal of Vaccines and Immunization, 2022, 28(4): 417-421. DOI: 10.19914/j.CJVI.2022080.
[6]	陈奕娟, 孙琬琬, 陈直平, 等. 2005—2020年浙江省戊型病毒性肝炎时空特征[J]. 中华疾病控制杂志, 2023, 27(9): 1101-1106. doi: 10.16462/j.cnki.zhjbkz.2023.09.020 Chen YJ, Sun WW, Chen ZP, et al. Spatial and temporal characteristics of viral hepatitis E in Zhejiang Province, 2005-2020[J]. Chin J Dis Control Prev, 2023, 27(9): 1101-1106. doi: 10.16462/j.cnki.zhjbkz.2023.09.020
[7]	齐孝旗, 欧剑鸣, 陈武, 等. 福建省2012—2021年戊型病毒性肝炎流行特征[J]. 中国热带医学, 2023, 23(9): 902-905. DOI: 10.13604/j.cnki.46-1064/r.2023.09.02. Qi XQ, Ou JM, Chen W, et al. Epidemiologic characteristics of viral hepatitis E in Fujian Province from 2012 to 2021[J]. China Tropical Medicine, 2023, 23(9): 902-905. DOI: 10.13604/j.cnki.46-1064/r.2023.09.02.
[8]	中国戊型病毒性肝炎院内筛查管理流程专家共识(2023年版)[J]. 临床肝胆病杂志, 2023, 39(4): 785-794. DOI: 10.3969/j.issn.1001-5256.2023.04.008. Expert consensus on the management process of in-hospital screening for viral hepatitis E in China (2023 edition)[J]. J Clin Hepatol, 2023, 39(4): 785-794. DOI: 10.3969/j.issn.1001-5256.2023.04.008.
[9]	刘淼. 戊型肝炎病毒与血液安全的研究进展[J]. 中国输血杂志, 2023, 36(4): 359-364. DOI: 10.13303/j.cjbt.issn.1004-549x.2023.04.017. Liu M. Research progress on hepatitis E virus and blood safety[J]. Chin J Blood Transfusion, 2023, 36(4): 359-364. DOI: 10.13303/j.cjbt.issn.1004-549x.2023.04.017.
[10]	Stunnenberg M, Huizen S, Swart A, et al. Thermal inactivation of hepatitis E virus in pork products estimated with a semiquantitative infectivity assay[J]. Microorganisms, 2023, 11(10). DOI: 10.3390/microorganisms11102451.
[11]	胡龙, 肖隽, 胡艳芳, 等. 2004—2019年湖北省戊型肝炎流行特征[J]. 公共卫生与预防医学, 2021, 32(5): 93-96. DOI: 10.3969/j.issn.1006－2483.2021.05.021. Hu L, Xiao J, Hu YF, et al. Epidemiologic characteristics of hepatitis E in Hubei Province, 2004-2019[J]. J Pub Health Prev Med, 2021, 32(5): 93-96. DOI: 10.3969/j.issn.1006－2483.2021.05.021.
[12]	崔伟红, 李娜, 李波. 2016-2020年烟台市戊型病毒性肝炎流行病学特征[J]. 中国疫苗和免疫, 2021, 27(6): 663-666. DOI: 10.19914/j.CJVI.2021121. Cui WH, Li N, Li B. Epidemiologic characteristics of viral hepatitis E in Yantai City from 2016 to 2020[J]. Chinese Journal of Vaccines and Immunization, 2021, 27(6): 663-666. DOI: 10.19914/j.CJVI.2021121.
[13]	Pokhrel S, Bhusal A, Kumari N, et al. Hepatitis-E-induced cholestasis in a child: a case report[J]. Ann Med Surg (Lond), 2023, 85(6): 3039-3042. DOI: 10.1097/MS9.0000000000000748.
[14]	唐莹, 管文齐, 王凤双, 等. 2005—2019年北京市顺义区戊型肝炎流行病学特征及危险因素分析[J]. 华南预防医学, 2021, 47(7): 926-929. https://www.cnki.com.cn/Article/CJFDTOTAL-GDWF202107027.htm Tang Y, Guan WQ, Wang FS et al. Epidemiological characteristics and risk factor analysis of hepatitis E in Shunyi District, Beijing, 2005-2019[J]. South China J Preve Med, 2021, 47(7): 926-929. https://www.cnki.com.cn/Article/CJFDTOTAL-GDWF202107027.htm
[15]	肖正斌, 陈恺韵, 任宏, 等. 2005—2019年戊型肝炎季节性流行特征及时间序列分析[J]. 上海预防医学, 2021, 33(10): 923-928. DOI: 10.19428/j.cnki.sjpm.2021.20817. Xiao ZB, Chen KY, Ren H, et al. Seasonal epidemiological characteristics and time series analysis of hepatitis E from 2005 to 2019[J]. Shanghai Journal of Preventive Medicine, 2021, 33(10): 923-928. DOI: 10.19428/j.cnki.sjpm.2021.20817.
[16]	李鹏. 2015~2019年沈阳市戊型病毒性肝炎流行特征分析[J]. 预防医学论坛, 2021, 27(1): 36-38. DOI: 10.16406/j.pmt.issn.1672-9153.2021.01.010. Li P. Characterization of the prevalence of viral hepatitis E in Shenyang City from 2015 to 2019[J]. Prev Med Trib, 2021, 27(1): 36-38. DOI: 10.16406/j.pmt.issn.1672-9153.2021.01.010.