山东省居民尿钠钾水平及其与血压的相关性研究

郭瑞; 张丙银; 徐春晓; 董静; 任杰; 刘丹茹; 鹿子龙; 郭晓雷

doi:10.16462/j.cnki.zhjbkz.2024.08.010

山东省居民尿钠钾水平及其与血压的相关性研究

doi: 10.16462/j.cnki.zhjbkz.2024.08.010

1.
山东大学公共卫生学院流行病学系，济南 250012
2.
山东省疾病预防控制中心慢性非传染性疾病防制所，济南 250014

基金项目: 国家卫生健康委山东省人民政府联合三减控三高项目(2019)

详细信息

通讯作者:
郭晓雷，E-mail : guoxiaolei@126.com

中图分类号: R181.2⁺3
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出版历程
- 收稿日期: 2024-02-29
- 修回日期: 2024-05-17
- 网络出版日期: 2024-09-29
- 刊出日期: 2024-08-10

Association between urinary sodium and potassium excretion and blood pressure among adults in Shandong Province, China

1.
Department of Epidemiology, School of Public Health, Shandong University, Jinan 250012, China
2.
Department of Non-Communicable Disease Prevention, Shandong Province Center for Disease Control and Prevention, Jinan 250014, China

Funds: Fund program: Joint Three Reduction and Three High Control Project of the National Health Commission and Shandong Provincial People′s Government (2019)

More Information

Corresponding author: GUO Xiaolei, E-mail: guoxiaolei@126.com

摘要

摘要: 目的分析山东省居民尿钠钾水平与高血压患病风险及血压水平的关系。方法 2019年在山东省选取18~69岁居民进行问卷调查、体格测量及随机点尿采集。通过Tanaka公式以点尿估计24 h尿钠钾水平，采用限制性立方样条、logistic回归分析模型和线性回归分析模型分析24 h尿钠钾水平与高血压患病风险及血压水平的剂量-反应关系及关联模式，并按年龄、性别和是否服用降压药进行亚组分析。结果共纳入3 280人，24 h尿钠、尿钾及尿钠钾比为(4.12±0.95)g/d、(1.70±0.39)g/d和(2.51±0.69)。24 h尿钠升高1 g/d，收缩压升高1.221 mmHg(95% CI：0.611~1.830, P < 0.001)、舒张压升高0.612 mmHg(95% CI：0.201~1.023, P=0.004)，24 h尿钾升高1 g/d，收缩压降低2.297 mmHg(95% CI：-3.797~-0.796, P=0.003)、舒张压降低1.159 mmHg(95% CI：-2.171~-0.147, P=0.025)。与尿钠钾比 < 2.0组相比，≥2.9组高血压患病风险增加37%(95% CI：1.062~1.769, P=0.015)，收缩压升高3.047 mmHg(95% CI：1.470~4.624, P < 0.001)，舒张压升高1.796 mmHg(95% CI：0.734~2.859, P=0.001)。除性别和尿钾与收缩压的关联存在相乘交互作用(P=0.015)，其他指标无交互作用。结论随尿钠升高、尿钾降低，高血压患病风险、收缩压和舒张压均呈上升趋势，随机点尿用于大型流行病学调查中评估高血压患病风险具有一定科学性。
- 尿钠钾排泄 /
- 高血压 /
- 收缩压 /
- 舒张压
Abstract: Objective To analyze the association between urinary sodium and potassium excretion with the risk of hypertension and blood pressure levels among adults in Shandong Province, China. Methods Residents aged 18-69 years were selected for questionnaire survey, physical examination, and random spot urine collection in Shandong Province in 2019. The 24 hour urinary sodium and potassium excretion was estimated by spot urine through the Tanaka formula. Dose-response relationship and association of 24 hour urinary sodium and potassium excretion with the risk of hypertension and blood pressure levels using restricted cubic spline, logistic regression models, and linear regression models. Subgroup analyses were conducted according to different ages, genders, and antihypertensive drug usage. Results A total of 3 280 subjects were included, 24 hour urinary sodium, urinary potassium and urinary sodium-potassium ratios were (4.12±0.95) g/d, (1.70±0.39) g/d and (2.51±0.69). For every 1g/d increase in sodium excretion, systolic blood pressure increases by 1.221 mmHg (95% CI: 0.611-1.830, P < 0.001), and diastolic blood pressure increases by 0.612 mmHg (95% CI: 0.201-1.023, P=0.004). For every 1g/d increase in potassium excretion, systolic blood pressure decreases by 2.297 mmHg (95% CI: -3.797--0.796, P=0.003) and diastolic blood pressure decreases by 1.159 mmHg (95% CI: -2.171--0.147, P=0.025). Compared with the group with a urinary sodium-potassium ratio of < 2.0, the ≥2.9 group increases the risk of hypertension by 37% (95% CI: 1.062-1.769, P=0.015), with an increase in systolic blood pressure of 3.047 mmHg (95% CI: 1.470-4.624, P < 0.001) and diastolic blood pressure of 1.796 mmHg (95% CI: 0.734-2.859, P=0.001). There was no interaction for any of the metrics except for a multiplicative interaction for gender and urinary potassium in the association with systolic blood pressure (P=0.015). Conclusions With the increase of urinary sodium and the decrease of urinary potassium, the risk of hypertension, systolic blood pressure and diastolic blood pressure all increase, and the use of random spot urine for assessing the risk of hypertension in large epidemiological surveys is scientifically valid.
- Urinary sodium and potassium excretion /
- Hypertension /
- Systolic blood pressure /
- Diastolic blood pressure

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图 1 24 h尿钠钾排泄水平与高血压患病风险及收缩压和舒张压的剂量-反应关系

模型调整年龄、性别、教育程度、体力活动、吸烟、饮酒、BMI、糖尿病、血脂异常和食用低钠盐; A：24 h尿钠排泄水平与高血压患病风险的剂量-反应关系；B：24 h尿钠排泄水平与收缩压的剂量-反应关系；C：24 h尿钠排泄水平与舒张压的剂量-反应关系；D：24 h尿钾排泄水平与高血压患病风险的剂量-反应关系；E：24 h尿钾排泄水平与收缩压的剂量-反应关系；F：24 h尿钾排泄水平与舒张压的剂量-反应关系；G：24 h尿钠钾比水平与高血压患病风险的剂量-反应关系；H：24 h尿钠钾比水平与收缩压的剂量-反应关系；I：24 h尿钠钾比水平与舒张压的剂量-反应关系。

Figure 1. The dose-response relationship between 24-hour urinary sodium and potassium excretion and the risk of hypertension, as well as systolic and diastolic blood pressure

Models adjusted for age, sex, education, physical activity, smoking, drinking, BMI, diabetes, dyslipidemia, and consumption of low-sodium salt; A: The dose-response relationship between 24-hour urinary sodium excretion and the risk of hypertension; B: The dose-response relationship between 24-hour urinary sodium excretion and systolic blood pressure; C: The dose-response relationship between 24-hour urinary sodium excretion and diastolic blood pressure; D: The dose-response relationship between 24-hour urinary potassium excretion and the risk of hypertension; E: The dose-response relationship between 24-hour urinary potassium excretion and systolic blood pressure; F: The dose-response relationship between 24-hour urinary potassium excretion and diastolic blood pressure; G: The dose-response relationship between 24-hour urinary sodium-to-potassium ratio and the risk of hypertension; H: The dose-response relationship between 24-hour urinary; I: The dose-response relationship between 24-hour urine sodium-potassium ratio level and diastolic blood pressure.

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图 2 24 h尿钠钾排泄水平与高血压患病风险及血压水平的关联的年龄、性别及服用药物情况亚组分析

模型调整年龄、性别、教育程度、体力活动、吸烟、饮酒、BMI、糖尿病、血脂异常和食用低钠盐；“-”表示为数据无法获得; 箭头表示OR值未完全展示。

Figure 2. The correlation between 24-hour urinary sodium and potassium excretion and the risk of hypertension as well as blood pressure levels: ages, genders, and antihypertensive drug usage subgroup analysis

Models adjusted for age, sex, education, physical activity, smoking, drinking, BMI, diabetes, dyslipidemia, and consumption of low-sodium salt; "-" indicates that the data is not available; An arrow indicates that the OR value is not fully displayed.

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表 1 研究对象的基本特征

Table 1. Characteristics of study participants

变量 Variable	总人群 Total population ^① (n=3 280)	高血压患者 Hypertensive patients ^① (n=875)	非高血压者 Non-hypertensive patients ^① (n=2 405)	χ²/t/H值 value	P值 value
年龄/岁Age/years	44.36±13.91	52.10±11.39	41.54±13.68	-22.185	< 0.001
性别 Gender				24.068	< 0.001
男性 Male	1 437(43.8)	445(50.9)	992(41.2)
女性 Female	1 843(56.2)	430(49.1)	1 413(58.8)
教育程度 Education				-10.570 ^②	< 0.001 ^②
小学及以下 Primary and below	1 076(32.8)	398(45.5)	678(28.2)
初中 Junior High School	1 353(41.2)	335(38.3)	1 018(42.3)
高中 High School	566(17.3)	119(13.6)	447(18.6)
大专及以上 College and above	285(8.7)	23(2.6)	262(10.9)
体力活动 Physical activity				-0.370 ^②	0.711 ^②
低水平 Low level	2 134(65.1)	571(65.3)	1 563(65.0)
中水平 Medium level	241(7.3)	46(5.3)	195(8.1)
高水平 High level	905(27.6)	258(29.5)	647(26.9)
吸烟 Smoking				5.827	0.018
否 No	2 450(74.7)	627(71.7)	1823(75.8)
是 Yes	830(25.3)	248(28.3)	582(24.2)
饮酒 Drinking				5.917	0.017
否 No	1 716(52.3)	427(48.8)	1 289(53.6)
是 Yes	1 564(47.7)	448(51.2)	1 116(46.4)
糖尿病 Diabetes				93.064	< 0.001
否 No	2 896(88.3)	694(79.3)	2 202(91.6)
是 Yes	384(11.7)	181(20.7)	203(8.4)
血脂异常 Dyslipidemia				120.477	< 0.001
否 No	2 179(66.4)	450(51.4)	1 729(71.9)
是 Yes	1 101(33.6)	425(48.6)	676(28.1)
食用低钠盐 Low-sodium salt				11.189	0.001
否 No	2 512(76.6)	706(80.7)	1 806(75.1)
是 Yes	768(23.4)	169(19.3)	599(24.9)
BMI/(kg·m^-2)	25.28±4.76	27.41±5.85	24.51±4.03	-13.535	< 0.001
SBP/mmHg	125.53±18.60	147.72±16.38	117.46±11.41	-50.343	< 0.001
DBP/mmHg	76.06±12.10	88.45±11.90	71.56±8.48	-38.571	< 0.001
点尿钠 Spot urine sodium/(mmol·L^-1)	152.89±76.84	150.19±75.33	153.87±77.37	1.228	0.225
点尿钾 Spot urine potassium/(mmol·L^-1)	45.01±28.26	43.44±27.46	45.58±28.54	1.954	0.055
24 h尿钠估计值 24 h urine sodium estimate/(g·d^-1)	4.12±0.95	4.22±1.00	4.08±0.93	-3.629	< 0.001
24 h尿钾估计值 24 h urine potassium estimate/(g·d^-1)	1.70±0.39	1.72±0.38	1.69±0.39	-1.914	0.060
24 h尿钠钾比 24 h urine sodium-to-potassium ratio	2.51±0.69	2.54±0.72	2.50±0.68	-1.347	0.168
注：SBP，收缩压；DBP，舒张压。 ①以人数(占比/%)或(x±s)表示；②秩和检验。 Note: SBP, systolic blood pressure; DBP, diastolic blood pressure. ① Number of people (proportion/%) or (x±s); ② Wilcoxon rank-sum test.

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表 2 24 h尿钠钾排泄水平与高血压患病风险及血压水平的相关性

Table 2. The correlation between 24 hour urinary sodium and potassium excretion and the risk of hypertension as well as blood pressure levels

变量/结局 Variable/outcome	高血压患病风险 Risk of hypertension OR值 value(95% CI)		收缩压 Systolic blood pressure β值 value(95% CI)		舒张压 Diastolic blood pressure β值 value(95% CI)
变量/结局 Variable/outcome	粗模型 Crude model ^①	调整模型 Adjusted model ^②	粗模型 Crude model ^①	调整模型 Adjusted model ^②	粗模型 Crude model ^①	调整模型 Adjusted model ^②
24 h尿钠估计值
24 h urine sodium estimate/(g·d^-1)
连续变量 Continuous variable	1.166(1.076~1.264)	1.115(1.012~1.229)	2.148(1.484~2.812)	1.221(0.611~1.830)	1.314(0.882~1.745)	0.612(0.201~1.023)
分类变量 Categorical variable
Q1(< 3.5)	―	―	―	―	―	―
Q2(3.5~ < 4.1)	1.091(0.870~1.368)	1.109(0.859~1.434)	1.699(-0.093~3.492)	1.477(-0.061~3.015)	0.977(-0.188~2.142)	0.719(-0.318~1.757)
Q3(4.1~ < 4.7)	1.177(0.942~1.475)	1.131(0.875~1.463)	2.700(0.909~4.492)	1.627(0.070~3.185)	1.538(0.374~2.702)	0.682(-0.368~1.732)
Q4(≥4.7)	1.538(1.237~1.915)	1.454(1.131~1.898)	5.904(4.112~7.696)	3.975(2.359~5.591)	3.732(2.567~4.896)	2.197(1.107~3.287)
24 h尿钾估计值 24 h urine potassium estimate/(g·d^-1)
连续变量 Continuous variable	1.207(0.992~1.468)	0.768(0.602~0.977)	1.771(0.140~3.402)	-2.297(-3.797~-0.796)	0.891(-0.169~1.951)	-1.159(-2.171~-0.147)
分类变量 Categorical variable
Q1(< 1.4)	―	―	―	―	―	―
Q2(1.4~ < 1.7)	1.261(1.009~1.576)	0.940(0.728~1.215)	1.538(-0.265~3.341)	-0.972(-2.528~0.585)	0.320(-0.852~1.492)	-0.975(-2.024~0.074)
Q3(1.7~ < 1.9)	1.307(1.047~1.633)	0.878(0.679~1.135)	2.361(0.559~4.164)	-1.163(-2.739~0.413)	1.238(0.067~2.410)	-0.553(-1.615~0.510)
Q4(≥1.9)	1.215(0.972~1.520)	0.787(0.602~1.029)	1.530(-0.271~3.332)	-2.362(-3.998~-0.727)	0.432(-0.739~1.603)	-1.621(-2.723~-0.518)
24 h尿钠钾比 24 h urine sodium-to-potassium ratio
连续变量 Continuous variable	1.081(0.967~1.208)	1.192(1.046~1.359)	1.518(0.598~2.438)	1.631(0.823~2.439)	1.054(0.456~1.652)	0.831(0.286~1.376)
分类变量 Categorical variable
Q1(< 2.0)	―	―	―	―	―	―
Q2(2.0~ < 2.4)	0.981(0.786~1.225)	1.037(0.806~1.332)	1.442(-0.359~3.243)	1.514(-0.029~3.056)	1.287(0.118~2.457)	1.190(0.151~2.230)
Q3(2.4~ < 2.9)	1.058(0.849~1.319)	1.084(0.844~1.394)	2.472(0.671~4.272)	1.933(0.383~3.484)	1.934(0.765~3.103)	1.353(0.309~2.398)
Q4(≥2.9)	1.146(0.921~1.425)	1.370(1.062~1.769)	2.825(1.023~4.626)	3.047(1.470~4.624)	2.148(0.978~3.317)	1.796(0.734~2.859)
注：①粗模型未调整任何变量；②调整模型调整年龄、性别、教育程度、体力活动、吸烟、饮酒、BMI、糖尿病、血脂异常和食用低钠盐；“―”表示以Q1组为对照。 Note: ①The crude model did not adjust for any variables; ②the adjusted model adjusted for age, sex, education, physical activity, smoking, drinking, BMI, diabetes mellitus, dyslipidemia, and consumption of low-sodium salt; "―" indicates that the Q1 group is used as a control.

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