2010―2020年江苏省育龄人群乙型肝炎病毒血清学检测结果

李孟兰; 吴玉璘; 黄丽丽; 封婕; 张瑞金; 刘帅妹; 周青; 林宁

doi:10.16462/j.cnki.zhjbkz.2024.11.006

2010―2020年江苏省育龄人群乙型肝炎病毒血清学检测结果

doi: 10.16462/j.cnki.zhjbkz.2024.11.006

李孟兰^{1, 2, 3},
吴玉璘^{1, 2, 3},
黄丽丽^{1, 2, 3},
封婕^{1, 2, 3},
张瑞金^{1, 2, 3},
刘帅妹^{1, 2, 3},
周青^{1, 2, 3},
林宁^{1, 2, 3, ,}

1.
江苏省卫生健康发展研究中心，南京 210036
2.
国家卫生健康委避孕药具警戒与生育力监测重点实验室，南京 210036
3.
江苏省生育力保护与卫生技术评估重点实验室，南京 210036

基金项目:

江苏省卫生健康委科研项目 M2020101

江苏省科教能力提升工程 ZDXYS202210

详细信息

通讯作者:
林宁，E-mail: 945230710@qq.com

中图分类号: R446.6
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- 文章访问数: 58
- HTML全文浏览量: 21
- PDF下载量: 10
- 被引次数: 0
出版历程
- 收稿日期: 2024-05-29
- 修回日期: 2024-09-03
- 网络出版日期: 2024-12-23
- 刊出日期: 2024-11-10

Serological testing results of hepatitis B virus among the population of childbearing age in Jiangsu Province from 2010 to 2020

LI Menglan^{1, 2, 3},
WU Yulin^{1, 2, 3},
HUANG Lili^{1, 2, 3},
FENG Jie^{1, 2, 3},
ZHANG Ruijin^{1, 2, 3},
LIU Shuaimei^{1, 2, 3},
ZHOU Qing^{1, 2, 3},
LIN Ning^{1, 2, 3
, ,}

1.
Jiangsu Health Development Research Center, Nanjing 210036, China
2.
NHC Key Laboratory of Contraceptives Vigilance and Fertility Surveillance, Nanjing 210036, China
3.
Jiangsu Provincial Medical Key Laboratory of Fertility Protection and Health Technology Assessment, Nanjing 210036, China

Funds:

Scientific Research Project of Jiangsu Provincial Health Commission M2020101

Jiangsu Province Capability Improvement Project Through Science, Technology and Education ZDXYS202210

More Information

Corresponding author: LIN Ning, E-mail: 945230710@qq.com

摘要

摘要: 目的了解2010―2020年江苏省育龄人群乙型肝炎病毒(hepatitis B virus, HBV)血清学检测结果，为科学防控HBV感染提供参考。方法收集2010―2020年参加国家免费孕前优生健康检查项目的1 061 396例(530 698对)育龄人群HBV血清学检测结果，分析江苏省育龄人群HBV感染现状和影响因素。结果 2010―2020年江苏省育龄人群乙型肝炎表面抗原(hepatitis B surface antigen, HBsAg)总阳性率为4.49%，乙型肝炎表面抗体(hepatitis B surface antibody, HBsAb)总阳性率为35.82%，HBsAg阳性率和HBsAb阳性率均呈下降趋势(HBsAg：趋势χ² =542.665, P < 0.001; HBsAb：趋势χ² =727.147, P < 0.001)。不同检测年份、性别、年龄、文化程度和职业的育龄人群HBsAg阳性率、HBsAb阳性率差异均有统计学意义(均P < 0.001)，不同民族、疫苗接种情况、户口的育龄人群HBsAb阳性率差异均有统计学意义(均P < 0.001)，但HBsAg阳性率差异无统计学意义(P>0.05)。育龄夫妇中，单独一方HBsAg阳性的占8.33%，其中50.67%的配偶HBsAb为阴性。结论江苏省育龄人群HBV感染率处于全国中等水平，2010―2020年育龄人群HBsAg阳性率逐渐降低。HBsAb阳性率偏低，大部分育龄人群属于HBV易感人群，尤其是在单独一方HBsAg阳性的家庭中，＞50%的配偶HBsAb为阴性，建议及时进行乙型肝炎疫苗接种、提高HBsAb保护率。HBsAg阳性率还与性别、年龄、文化程度、职业等因素相关，需制定针对性的防控措施，进一步巩固和加强乙型病毒性肝炎防控效果。
- 乙型肝炎病毒 /
- 乙型肝炎表面抗原 /
- 乙型肝炎表面抗体 /
- 孕前优生健康检查
Abstract: Objective To investigate the serological testing results of HBV among the population of childbearing age in Jiangsu Province from 2010 to 2020, and to provide reference for scientific prevention and control of HBV infection. Methods Serological testing results of HBV were collected from 1 061 396 cases (530 698 pairs) of childbearing age population who participated in the national free pre-pregnancy health examination program from 2010 to 2020, and the HBV infection status and influencing factors were analyzed in Jiangsu Province. Results From 2010 to 2020, the total positive rate of HBsAg and HBsAb was 4.49% and 35.82% respectively in Jiangsu Province, and the positive rate of HBsAg and HBsAb showed an downward trend (HBsAg: trend χ² =542.665, P < 0.001; HBsAb: trend χ² =727.147, P < 0.001). The positive rate of HBsAg and HBsAb were statistically significant in different testing years, gender, age groups, educational levels and occupations (all P < 0.001). The positive rate of HBsAb was also statistically significant in different ethnic groups, hepatitis B vaccination status and registered permanent residence (all P < 0.001), but there was no significant difference in the positive rate of HBsAg (P>0.05). Among the couples of childbearing age, 8.33% of husbands or wives whose HBsAg test results was positive alone, while 50.67% of their spouses tested negative for HBsAb. Conclusions The overall HBV infection rate among the population of childbearing age in Jiangsu Province is at the medium level, and the positive rate of HBsAg decreased gradually from 2010 to 2020. However, the overall positive rate of HBsAb is still low, and most people of the childbearing age are susceptible to HBV, especially in the families whose husbands or wives tested positive for HBsAg alone. Cosidering over half of their spouses tested negative for HBsAb, emphasizing the importance of timely hepatitis B vaccination and improving the protection rate of HBsAb.The positive rate of HBsAg is also related to different gender, age groups, educational level, occupation and other factors, it is necessary to formulate targeted prevention and control measures to further consolidate and strengthen the prevention and control effect of HBV.
- Hepatitis B virus /
- Hepatitis B surface antigen /
- Hepatitis B surface antibody /
- Pre-pregnancy health examination

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表 1 2010―2020年江苏省育龄人群HBsAg、HBsAb检测结果

Table 1. Detection results of HBsAg and HBsAb of childbearing age in Jiangsu Province from 2010 to 2020

检测年份 Year of detection	总数 Total	HBsAg(+)^①	HBsAb(+)^①
2010	24 006	741(3.09)	6 635(27.64)
2011	101 222	4 746(4.69)	34 779(34.36)
2012	169 540	9 018(5.32)	63 758(37.61)
2013	167 034	8 307(4.97)	64 570(38.66)
2014	149 136	7 167(4.81)	58 867(39.47)
2015	135 638	5 746(4.24)	47 180(34.78)
2016	103 804	4 383(4.22)	36 653(35.31)
2017	83 354	3 241(3.89)	26 330(31.59)
2018	67 074	2 422(3.61)	22 059(32.89)
2019	55 184	1 761(3.19)	17 758(32.18)
2020	5 404	140(2.59)	1 556(28.79)
χ²值 value		1 008.110	3 887.843
趋势χ²值 value		542.665	727.147
P值 value		< 0.001	< 0.001
合计 Total	1 061 396	47 672(4.49)	380 145(35.82)
注：HBsAg，乙型肝炎表面抗原；HBsAb，乙型肝炎表面抗体。 ①以人数(占比/%)表示。 Note: HBsAg, hepatitis B surface antigen; HBsAb, hepatitis B surface antibody. ① Number of people (proportion/%).

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表 2 不同人口学特征的育龄人群HBsAg和HBsAb阳性分布情况

Table 2. Distribution of HBsAg and HBsAb positivity in the population of childbearing age with different demographic characteristics

变量 Variable	合计 Total	HBsAg(+)^①	χ²值 value	P值 value	HBsAb(+)^①	χ²值 value	P值 value
性别 Gender			1 036.592	< 0.001		317.601	< 0.001
女性 Female	530 698	20 401(3.84)			194 474(36.64)
男性 Male	530 698	27 271(5.14)			185 671(34.99)
年龄/岁 Age/years			2 988.491	< 0.001		686.893	< 0.001
< 20	3 892	97(2.49)			1 257(32.30)
20~ < 25	308 761	10 512(3.40)			112 173(36.33)
25~ < 30	481 647	20 485(4.25)			176 490(36.64)
30~ < 35	167 787	9 705(5.78)			56 936(33.93)
35~ < 40	69 680	4 744(6.81)			23 396(33.58)
40~ < 45	24 676	1 818(7.37)			8 262(33.48)
≥45	4 953	311(6.28)			1 631(32.93)
民族 Ethnic group			1.373	0.241		17.072	< 0.001
汉族 Han	1 058 989	47 552(4.49)			379 380(35.82)
少数民族 Minority	2 407	120(4.99)			765(31.78)
文化程度 Educational level			571.614	< 0.001		3 669.949	< 0.001
文盲 Illiteracy	2 627	114(4.34)			645(24.55)
小学 Primary school	11 192	561(5.01)			3 423(30.58)
初中 Junior high school	320 575	16 127(5.03)			109 096(34.03)
高中 Senior high school	342 877	15 938(4.65)			116 475(33.97)
大专/本科 Junior college /undergraduate	376 018	14 631(3.89)			146 331(38.92)
研究生及以上 Master degree or above	8 107	301(3.71)			4 175(51.50)
职业 Occupation			693.535	< 0.001		2 540.128	< 0.001
农民 Farmer	322 792	14 742(4.57)			113 733(35.23)
工人 Worker	430 074	20 627(4.80)			148 672(34.57)
服务业 Service	83 914	3 803(4.53)			30 464(36.30)
经商 Business	53 781	2 673(4.97)			19 248(35.79)
家务 Homeworker	16 559	681(4.11)			6 132(37.03)
教师、公务员、职员等 Teacher, civil servant, employee, etc	106 904	3 228(3.02)			45 552(42.61)
其他 Others	47 372	1 918(4.05)			16 344(34.5)
疫苗接种情况 Hepatitis B vaccination status			1.826	0.177		4 535.512	< 0.001
是 Yes	243 125	11 041(4.54)			101 056(41.57)
否 No	818 271	36 631(4.48)			279 089(34.11)
户口 Registered permanent residence			0.937	0.333		691.288	< 0.001
农业户口 Agriculture account	980 991	44 006(4.49)			347 911(35.47)
非农业户口 Non-agriculture account	80 405	3 666(4.56)			32 234(40.09)
注：HBsAg，乙型肝炎表面抗原；HBsAb，乙型肝炎表面抗体。 ①以人数(占比/%)表示。 Note: HBsAg, hepatitis B surface antigen; HBsAb, hepatitis B surface antibody. ① Number of people (proportion/%).

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表 3 2010―2020年江苏省育龄夫妇HBsAg检测结果

Table 3. HBsAg detection results of couples of childbearing age in Jiangsu Province from 2010―2020

合计 Total	妻子单阳 The result of wife is positive^①	丈夫单阳 The result of husband is positive^①	夫妻双阳 The results of couples are all positive^①	夫妻双阴 The results of couples are all negative^①
530 698	18 668(3.52)	25 538(4.81)	1 733(0.33)	484 759(91.34)
注：HBsAg，乙型肝炎表面抗原。 ①以人数(占比/%)表示。 Note: HBsAg, hepatitis B surface antigen. ① Number of people (proportion/%).

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表 4 育龄夫妇一方HBsAg阳性时其配偶的HBsAb检测结果

Table 4. HBsAb test results of spouses in childbearing couples whose HBsAg test results of wife or husband is positive alone

变量 Variable	配偶Spouses HBsAb(+)^①	配偶Spouses HBsAb(-)^①
妻子单阳 HBsAg test results of wife is positive alone(n=18 668)	8 870(47.51)	9 798(52.49)
丈夫单阳 HBsAg test results of husband is positive alone(n=25 538)	12 935(50.65)	12 603(49.35)
合计 Total(n=44 206)	21 805(49.33)	22 401(50.67)
注：HBsAg，乙型肝炎表面抗原；HBsAb，乙型肝炎表面抗体。 ①以人数(占比/%)表示。 Note: HBsAg, hepatitis B surface antigen; HBsAb, hepatitis B surface antibody. ① Number of people (proportion/%).

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