An analysis of serum levels of BDNF and relative factors in the accident tendentiousness of drivers

Objective To explore the related factors of the accident tendentiousness drivers, and to investigate the relationship between the serum levels of brain-derived neurotrophic factor (BDNF) and the accident tendentiousness drivers. Methods A case-control study, including 50 patients and 50 controls, were inquired the general condition and the living habits by questionnaire, and serum BDNF levels were assayed by enzyme linked immunosorbent assay (ELISA). Results Serum BDNF was significantly higher (t=-2.564,P=0.012) in patients [(3.18±2.19)ng/ml] compared with the controls [(2.23±1.43)ng/ml]. Serum BDNF levels of the drivers with driving experience <10 years in exposure group was significantly higher(t=-2.141,P=0.038) than those in control group. Serum BDNF levels of the drivers with primary school and junior middle school education in exposure group was significantly higher(t=-2.562,P=0.018) than those in control group. Serum BDNF levels of the drivers with ethnic minorities in exposure group was significantly higher(t=-3.047,P=0.004) compared with the control group. Non-conditional logistic regression analyses showed that the relative factors of the accident proneness were birth place and exercise frequency(all P<0.05). Conclusions Our results suggest that the driver accident tendentiousness are associated with serum BDNF levels, and birth place and exercise frequency may be protective factors of the accident proneness.