Study on association of plasma trace elements concentration with HCV infection and liver function

XIE Chao-nan; WU Meng-ping; HUANG Peng; YUE Ming; PENG Zhi-hang; YU Rong-bin; WANG Jie; ZHANG Yun

doi:10.16462/j.cnki.zhjbkz.2016.09.003

Volume 20 Issue 9

Sep. 2016

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XIE Chao-nan, WU Meng-ping, HUANG Peng, YUE Ming, PENG Zhi-hang, YU Rong-bin, WANG Jie, ZHANG Yun. Study on association of plasma trace elements concentration with HCV infection and liver function[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(9): 872-875. doi: 10.16462/j.cnki.zhjbkz.2016.09.003

Citation:

XIE Chao-nan, WU Meng-ping, HUANG Peng, YUE Ming, PENG Zhi-hang, YU Rong-bin, WANG Jie, ZHANG Yun. Study on association of plasma trace elements concentration with HCV infection and liver function[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(9): 872-875. doi: 10.16462/j.cnki.zhjbkz.2016.09.003

Citation:

XIE Chao-nan, WU Meng-ping, HUANG Peng, YUE Ming, PENG Zhi-hang, YU Rong-bin, WANG Jie, ZHANG Yun. Study on association of plasma trace elements concentration with HCV infection and liver function[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2016, 20(9): 872-875. doi: 10.16462/j.cnki.zhjbkz.2016.09.003

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Study on association of plasma trace elements concentration with HCV infection and liver function

doi: 10.16462/j.cnki.zhjbkz.2016.09.003

1. Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 210029, China;
2. Department of Infectious Diseases, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;
3. Department of Fundamental Nursing, School of Nursing, Nanjing Medical University, Nanjing 210029, China;
4. Institute of Epidemiology and Microbiology, the Institute of Military Medicine of Nanjing Command, Nanjing 210002, China

Received Date: 2016-03-14
Rev Recd Date: 2016-07-24

Abstract

Abstract

Objective To explore the association of plasma microelements (Cu, Fe and Zn) concentration with hepatitis C virus (HCV) infection and liver function in hepatitis C patients. Methods In a case-control study, 281 participants, including 90 patients with chronic hepatitis C, 92 HCV natural clearance subjects and 99 healthy controls, were investigated. The subjects' plasma trace elements concentration was detected by inductively coupled plasma mass spectrometry (ICP-MS). And partial correlation analysis and multivariable logistic regression analysis were used to explore the relationship of microelements concentration and HCV viral load in patients with chronic HCV infection. Results Compared with healthy controls, the level of zinc was decreased, however, the level of iron was increased in patients with chronic HCV infection (all P<0.05). After controlling for age, sex and BMI, the HCV viral load was negatively correlated with plasma iron concentration (r=-0.263, P=0.016). The Logistic regression showed that iron was independently associated with ALT values in patients with persistent HCV infection (OR=1.001,95% CI:1.000-1.002,P=0.030). Conclusions Trace elements (Cu, Fe and Zn) may be associated with HCV infection outcomes. Especially, iron level is an independent risk factors of chronic HCV infection.
- Hepatitis C, chronic,
- Iron,
- Viral load

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References(17)

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