Serum total bilirubin distribution and its relation to dyslipidemia in children and adolescents

Objective To investigate serum total bilirubin(TBIL) distribution and its relation to dyslipidemia among children and adolescents. Methods A cross-sectional survey was performed among students from seven schools in Yixing City and 3 787 subjects who completed physical examination and blood biochemistry test after signing informed consent were included in the final analysis. Independent sample t test was performed to compare the differences of TBIL between male and female in different age groups. One-way ANOVA was performed to compare TBIL level among age group. Univariate and multiple logistic regression were applied to evaluate the risk of dyslipidemia according to TBIL level. Results The TBIL level increased with age continuously in 6-16 group both in male and female(all P_trend<0.05). The TBIL level of male were significantly lower than female in 7-, 8- and 10- age groups (all P<0.05). TBIL was positively correlated with high density lipoprotein and negatively correlated with triglyceride both in male and female (all P<0.001). TBIL was positively correlated with total cholesterol and low-density lipoprotein in female (all P<0.001). Compared with the lowest quartile TBIL subjects(Q1), the subjects in Q2(OR=0.690,95% CI:0.568-0.739,P<0.001),Q3(OR=0.575,95% CI:0.471-0.701,P<0.001),Q4(OR=0.552,95% CI:0.451-0.676,P<0.001) group were in lower risk of dyslipidemia after adjustment for age, sex and body mass index. Conclusions The serum TBIL ascended with age in children and adolescents, TBIL level of male was higher than female in old age group. High TBIL level could reduce the risk of dyslipidemia.