Relationship between HLA-DQ polymorphisms and outcome of HCV infection

Objective To explore the association of human leukocyte antigen-DQ (HLA-DQ)polymorphisms with outcome of hepatitis C virus (HCV)infection. Methods Two variants of rs2856718 and rs7453920 were genotyped among 262 HCV spontaneous clearance cases, 339 persistent HCV infection cases and 942 uninfected controls by using TaqMan technology. Results Logistic regression analyses showed that the genotype AG of rs2856718 significantly decreased the risk of HCV infection (adjusted OR=0.73, 95% CI:0.56-0.94). Moreover, the genotype AA of rs7453920 was correlated with elevated risk HCV infection (adjusted OR=1.75, 95% CI:1.01-3.03). Haplotype analysis also showed that haplotype AA significantly increased the risk of HCV infection (adjusted OR=1.67, 95% CI:1.11-2.52). Stratified Analysis suggested that the frequency of rs2856718 AG genotyoe in HCV infected group was much lower than that of uninfected control group among male patients (adjusted OR=0.68, 95% CI:0.51-0.93); the frequency of rs7453920 GG genotyoe in HCV infected group was much higher than that of uninfected control group among people who was 45 to 60 years old (adjusted OR=2.35, 95% CI:1.11-4.98). Conclusions HLA-DQ polymorphisms might play a vital role in the outcome of HCV infection.