Analysis on risk factors affecting the mortality of patients with coronary artery disease after undergoing percutaneous coronary intervention

Objective To discuss the risk factors of mortality after percutaneous coronary intervention (PCI) in patients with coronary heart disease. Methods A retrospective study was conducted among patients with coronary heart disease undergoing PCI with drug-eluting stents at four hospitals in China (Peking University People's Hospital; Beijing University of Chinese Medicine Dongzhimen Hospital; Cangzhou Central Hospital, Hebei Province; Luoyang Central Hospital, Henan Province) from January 1st, 2006 to June 30th, 2011. Multivariable cox proportional hazards models were used for analysis of mortality after PCI. Results 3 511 (85.4%) patients finished follow-up and the mortality after PCI was 4.6% (161/3 511). Age (HR=1.086, 95% CI:1.059-1.113, P<0.001), diabetes (HR=1.807, 95% CI:1.205-2.709, P=0.004), smoking (HR=1.873, 95% CI:1.205-2.709, P=0.002), anemia (HR=1.909, 95% CI:1.266-2.879,P=0.002), left ventricular ejection fraction <50% (HR=2.546, 95% CI:1.558-4.162, P<0.001) and dual antiplatelet therapy (DAPT) time less than one year (HR=0.029, 95% CI:0.013-0.067, P<0.001) were associated with increased all-cause mortality in patients undergoing PCI. Conclusions Age, diabetes, smoking, anemia, heart dysfunction and DAPT time less than one year were risk factors of mortality after PCI and it should be taken into account seriously and intervened properly.