Protective effect of bicyclol on anti-tuberculosis drug-induced hepatotoxicity:a Meta-analysis

Objective To evaluate the efficacy of bicyclol in the treatment of anti-tuberculosis drug-induced hepatotoxicity. Methods Data related to the efficacy of bicyclol in the treatment of anti-tuberculosis drug-induced liver injury were searched from databases including CBM, CNKI, WanFang, VIP Data, PUBMED, EMbase, Central, etc. The randomized controlled trials (RCT) were chosen based on the inclusion and exclusion criteria. Meta-analysis was performed using Stata 11.0 software. Results A total of 1 847 patients from 9 ramdomized controlled trial (RCT) were included, of which 998 were test cases and 849 were control cases. The meta-analysis results showed that the total effective rate of liver function improvement was higher in bicyclol group than that in control group(RR=1.277,95% CI:1.082-1.506,P=0.004). What's more, subgroup analysis showed that the total effective rate of the improvement of liver function within 2 weeks in the experimental group was better than that in control group (RR=1.224,95% CI:1.128-1.329,I²=0.0%,P=0.579); the total effective rate of the improvement of liver function within 4 weeks in the test group was significantly higher than that in control group (RR=1.337,95% CI:0.862-2.074,I²=97.4%,P<0.001). Finally, there was no significant difference between two groups in side effect (RR=0.921,95% CI:0.483-1.938,P=0.828). Conclusions Bicyclol is effective in improving liver injury induced by anti-tuberculosis drugs in tuberculosis (TB) patients.