Relationship between hyperuricemia and chronic kidney disease in adult residents of communities in the Songjiang district, Shanghai

ZHOU Xiao-yan; ZHAO Qi; WANG Na; WANG Rui-ping; ZHANG Yue; YU Yu-ting; JIANG Yong-gen; ZHAO Gen-ming

doi:10.16462/j.cnki.zhjbkz.2019.03.007

Volume 23 Issue 3

Mar. 2019

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2019 > 23(3): 278-282, 293

ZHOU Xiao-yan, ZHAO Qi, WANG Na, WANG Rui-ping, ZHANG Yue, YU Yu-ting, JIANG Yong-gen, ZHAO Gen-ming. Relationship between hyperuricemia and chronic kidney disease in adult residents of communities in the Songjiang district, Shanghai[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(3): 278-282, 293. doi: 10.16462/j.cnki.zhjbkz.2019.03.007

Citation:

ZHOU Xiao-yan, ZHAO Qi, WANG Na, WANG Rui-ping, ZHANG Yue, YU Yu-ting, JIANG Yong-gen, ZHAO Gen-ming. Relationship between hyperuricemia and chronic kidney disease in adult residents of communities in the Songjiang district, Shanghai[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(3): 278-282, 293. doi: 10.16462/j.cnki.zhjbkz.2019.03.007

Citation:

ZHOU Xiao-yan, ZHAO Qi, WANG Na, WANG Rui-ping, ZHANG Yue, YU Yu-ting, JIANG Yong-gen, ZHAO Gen-ming. Relationship between hyperuricemia and chronic kidney disease in adult residents of communities in the Songjiang district, Shanghai[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(3): 278-282, 293. doi: 10.16462/j.cnki.zhjbkz.2019.03.007

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Relationship between hyperuricemia and chronic kidney disease in adult residents of communities in the Songjiang district, Shanghai

doi: 10.16462/j.cnki.zhjbkz.2019.03.007

ZHOU Xiao-yan^{1, 2},
ZHAO Qi^{1, 2},
WANG Na^{1, 2},
WANG Rui-ping³,
ZHANG Yue^{1, 2},
YU Yu-ting^{1, 2},
JIANG Yong-gen³,
ZHAO Gen-ming^{1, 2
,
,}

1.
Department of Epidemiology, School of Public Health, Fudan University, Shanghai 200032, China
2.
Key Laboratory of Public Health Safety, Ministry of Education, Shanghai 200032, China
3.
Songjiang District Center for Disease Control and Prevention, Shanghai 201600, China

Received Date: 2018-09-13
Rev Recd Date: 2018-11-23
Publish Date: 2019-03-10

Abstract

Abstract

Objective To explore the relationships between hyperuricemia (HUA), serum uric acid (SUA) level and the chronic kidney disease (CKD) in adult residents of communities. Methods A cross-sectional study was conducted in Xinqiao town of Songjiang district, Shanghai and a total of 9 527 residents aged 20-75 years were selected by random cluster sampling. Logistic regression models were used to evaluate the association between SUA and CKD. Results Subjects were divided into five groups according to the gender-specific quintiles of SUA. The CKD prevalence in serum uric acid quintiles of male were 4.9%, 5.7%, 6.0%, 8.0% and 13.8% respectively, while of female were 12.8%, 12.7%, 11.9%, 13.3% and 18.2% respectively, increasing along with the increase of SUA among both sexes (all P<0.05). Compared to the serum uric acid first quintile, the multivariate-adjusted odds for CKD in male of the fourth and fifth quintiles were 2.12 (95% CI: 1.32-3.39) and 3.84 (95% CI: 2.45-6.02), and the multivariate-adjusted odds for CKD in female of the fifth quintile was 1.38 (95% CI: 1.05-1.80). Hyperuricemia was defined by SUA>420 μmol/L(male) or >360 μmol/L(female). In the unadjusted model, HUA was significantly associated with CKD of all subjects (OR=2.03, 95% CI: 1.69-2.44, P<0.001), and the association was still significant (OR=2.04, 95% CI: 1.68-2.49, P<0.001) after adjustment for the potential confounders. The multivariate-adjusted odds of CKD associated with HUA was 2.89 (95% CI: 2.12-3.94, ) and 1.98 (95% CI: 1.51-2.60) for male and female, respectively. Conclusion Hyperuricemia was independently associated with the increased prevalence of CKD among community-based population living in the Songjiang district, Shanghai.
- Uric acid,
- Hyperuricemia,
- Chronic kidney disease,
- Cross-sectional study

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References(21)

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