Clinicopathological features of LINE-1 gene methylation with esophageal cancer in a high incidence area in China

CUI Guo-yan; YANG Jian-zhou; CHEN Yun-xia; HU Wen-qing; WANG Jin-sheng

doi:10.16462/j.cnki.zhjbkz.2019.05.008

Volume 23 Issue 5

May 2019

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2019 > 23(5): 532-535

CUI Guo-yan, YANG Jian-zhou, CHEN Yun-xia, HU Wen-qing, WANG Jin-sheng. Clinicopathological features of LINE-1 gene methylation with esophageal cancer in a high incidence area in China[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(5): 532-535. doi: 10.16462/j.cnki.zhjbkz.2019.05.008

Citation:

CUI Guo-yan, YANG Jian-zhou, CHEN Yun-xia, HU Wen-qing, WANG Jin-sheng. Clinicopathological features of LINE-1 gene methylation with esophageal cancer in a high incidence area in China[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(5): 532-535. doi: 10.16462/j.cnki.zhjbkz.2019.05.008

Citation:

CUI Guo-yan, YANG Jian-zhou, CHEN Yun-xia, HU Wen-qing, WANG Jin-sheng. Clinicopathological features of LINE-1 gene methylation with esophageal cancer in a high incidence area in China[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(5): 532-535. doi: 10.16462/j.cnki.zhjbkz.2019.05.008

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Clinicopathological features of LINE-1 gene methylation with esophageal cancer in a high incidence area in China

doi: 10.16462/j.cnki.zhjbkz.2019.05.008

1.
Department of Microbiology of Changzhi Medical College, Changzhi 046000, China
2.
Public Health and Preventive Medicine of Changzhi Medical College, Changzhi 046000, China
3.
Department of general surgery of Heping Hospital, Changzhi Medical College, Changzhi 046000, China
4.
Department of Changzhi Medical College, Changzhi 046000, China

Funds:

Research Project Supported by Shanxi Scholarship Council of China 2014-072

Natural Science Foundation of Shanxi Province of China 2016011092

Shanxi Province Service Industry Innovation Discipline group Construction Plan 201809

More Information

Corresponding author: YANG Jian-zhou, E-mail: jzyang@aliyun.com
Received Date: 2018-09-26
Rev Recd Date: 2019-03-01
Publish Date: 2019-05-10

Abstract

Abstract

Objective To study the function of long interspersed nucleotide element-1 (LINE-1) promoter region methylation in the development of esophageal cancer. Methods Pyrosequencing was applied to detect methylation levels of the promoter region of LINE-1 in 96 cases of esophageal cancer tissuses, pericancerous tissue and tissues distant from esophageal cancer. Statistical methods were performed to correlate the level of LINE-1 methylation with clinical features and living habits of the patients. Results The methylation level of LINE-1 was not significantly different among the esophageal cancer tissuses, pericancerous tissue and tissues distant from esophageal cancer (all P>0.05). Among 96 cancer tissuses, no association was found between methylation status of LINE-1 promoter region and age, drinking, family history, histopathological types, tumor locaton and tumor stage (all P>0.05). Metylation status of LINE-1promoter region was associated with gender, smoking history and tumor differentiation (all P < 0.05). Conclusion The methylation of LINE-1 is frequently happened to esophageal cancer. Promoter region hypermethylation of LINE-1 is often occurred to poor differentiated esophageal cancer and advanced TNM stage. The methylation of LINE-1 may play an important role in the diagnosis and prognosis monitoring of esophageal cancer.
- Esophageal cancer,
- LINE-1 gene,
- Methylation

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References(11)

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