Study on genotype-associated HPV infection in cervical lesions

WANG Lan-fang; HU Shuang-jie; GE Xiao-wei; WANG Chao-hong; SUN Yu-xiu; SHEN Ji-long

doi:10.16462/j.cnki.zhjbkz.2019.05.009

Volume 23 Issue 5

May 2019

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WANG Lan-fang, HU Shuang-jie, GE Xiao-wei, WANG Chao-hong, SUN Yu-xiu, SHEN Ji-long. Study on genotype-associated HPV infection in cervical lesions[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(5): 536-539, 544. doi: 10.16462/j.cnki.zhjbkz.2019.05.009

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WANG Lan-fang, HU Shuang-jie, GE Xiao-wei, WANG Chao-hong, SUN Yu-xiu, SHEN Ji-long. Study on genotype-associated HPV infection in cervical lesions[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(5): 536-539, 544. doi: 10.16462/j.cnki.zhjbkz.2019.05.009

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Study on genotype-associated HPV infection in cervical lesions

doi: 10.16462/j.cnki.zhjbkz.2019.05.009

Clinical Laboratory, Maternal and Child Care Service Center of Anhui and Maternal and Child Hospital of Anhui Medical University, Hefei 230001, China

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Corresponding author: WANG Lan-fang, E-mail: regnier@ibpc.fr
Received Date: 2018-10-08
Rev Recd Date: 2019-03-01
Publish Date: 2019-05-10

Abstract

Abstract

Objective To explore the association of genotypes of human papillomavirus (HPV) with cervicitis, cervical intraepithelial neoplasia (CIN) and carcinoma in situ of cervix. Methods A total of 464 patients with cervical biology admitted to Hefei women and child health care hospital from October, 2014 to October, 2015 were selected. Among them, there were 242 cases of cervicitis, 222 cases of CIN (76 of group Ⅰ, 71 of group Ⅱ, and 66 of group Ⅲ), and 9 cases of cervical cancer. Hybrid chip technology was used to detect cervical secretions of patients, and 21 kinds of HPV DNA were typed according to histopathological biopsy. Results The HPV infection was found in 464 patients with cervical lesions. Among them, 354 cases (76.3%) had HPV infection with 232 cases (65.5%) of single HPV infection and 122 cases (34.5%) of multiple infections included. The rate of HPV infection was 64.9% in the group of cervicitis, while the rate was 86.8% in group Ⅰ of CIN and in group Ⅱ of CIN, the rate of HPV infection was 87.3%. Surprisingly, the HPV infection rate in group Ⅲ of CIN was as high as 90.9%. The infection rate of HPV in the patients with CIN was significantly higher than those with cervicitis (P < 0.001). All patients with cervical cancer were infected with HPV. Conclusions Persistent infection of high-risk HPV subtypes increases the hazard of cervical tumor and CIN. Therefore, genotyping of HPV DNA is helpful for screening and prediction of cervical cancer.
- HPV,
- Genotyping,
- Cervicitis,
- CIN,
- Cervical cancer

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References(20)

References

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