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CN 34-1304/RISSN 1674-3679

HUANG Zhu-hang, SU Jia-li, ZHENG Hui-zhen, ZHANG Yi-bin, TANG Yan, XIA Yan-hui, CHEN Yi-jian, ZHANG Lei, FAN Ren-feng, ZHANG Ji-kai. Persistence of rabies antibody 3 years after postexposure prophylaxis with 2-1-1 regimen of Vero-cell rabies vaccine for human use and antibody response to two booster doses[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(5): 607-612. doi: 10.16462/j.cnki.zhjbkz.2019.05.023
Citation: HUANG Zhu-hang, SU Jia-li, ZHENG Hui-zhen, ZHANG Yi-bin, TANG Yan, XIA Yan-hui, CHEN Yi-jian, ZHANG Lei, FAN Ren-feng, ZHANG Ji-kai. Persistence of rabies antibody 3 years after postexposure prophylaxis with 2-1-1 regimen of Vero-cell rabies vaccine for human use and antibody response to two booster doses[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(5): 607-612. doi: 10.16462/j.cnki.zhjbkz.2019.05.023

Persistence of rabies antibody 3 years after postexposure prophylaxis with 2-1-1 regimen of Vero-cell rabies vaccine for human use and antibody response to two booster doses

doi: 10.16462/j.cnki.zhjbkz.2019.05.023
Funds:

Guangdong technology service platform for clinical research on vaccines Guangdong provincial development and reform commission[2016] No. 779

Guangdong province laboratory system construction special funds Guangdong province vaccine safety key scientific research base, 2012A061300003

Guangzhou vaccine safety evaluation of key laboratory special funds 2014SY000009

Guangdong province medical science and technology research fund project B2016009

More Information
  • Corresponding author: ZHANG Ji-kai, E-mail: 527929822@qq.com
  • Received Date: 2018-11-28
  • Rev Recd Date: 2019-03-17
  • Publish Date: 2019-05-10
  •   Objective  To evaluate the antibody persistence following rabies postexposure prophylaxis (PEP) with 2-1-1 regimen and antibody response to two booster doses.  Methods  A total of 314 healthy volunteers at year 1, year 2, year 3 who had received a complete rabies PEP using 2-1-1 regimen were recruited. Two booster doses of rabies vaccine were inoculated, and blood samples were obtained before and 14 days after two booster doses. Human rabies virus IgG antibody was evaluated by ELISA, and the antibody levels and antibody positive rates were analyzed.  Results  The antibody GMC of 303 people at year 1, year 2, year 3 after a complete immunization was 1.33 IU/mL, 1.04 IU/mL and 0.72 IU/mL, with an antibody positive rate of 77.78%, 66.67% and 55.56%, respectively. Among 282 people who received 2 doses for booster immunization, the antibody GMC at day 14 of 1 year, 2 year and 3 year immunization group was 16.83 IU/mL, 19.37 IU/mL and 21.05 IU/mL respectively, which was higher than that before booster immunization (t=16.54, P < 0.001; t=13.85, P < 0.001; t=16.02, P < 0.001). The antibody positive rate was 100.00%, 99.00% and 100.00%, respectively.  Conclusions  The immune persistence of rabies antibody after PEP with antirabies vaccine using the 2-1-1 regimen is good so as to the immune response after 2 doses of booster immunization in 3 years is effective.
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