Association analysis between genetic variants in <i>STAT4</i>and pathological characteristics of primary liver cancer

ZHONG Xuan; ZHOU Xin-feng; WEI Zhi-mei; LIU Gui-yan; GAO Yan-hui; YU Xin-fa; CHEN Si-dong; LIU Li

doi:10.16462/j.cnki.zhjbkz.2019.08.021

Volume 23 Issue 8

Aug. 2019

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2019 > 23(8): 992-997

ZHONG Xuan, ZHOU Xin-feng, WEI Zhi-mei, LIU Gui-yan, GAO Yan-hui, YU Xin-fa, CHEN Si-dong, LIU Li. Association analysis between genetic variants in STAT4and pathological characteristics of primary liver cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(8): 992-997. doi: 10.16462/j.cnki.zhjbkz.2019.08.021

Citation:

ZHONG Xuan, ZHOU Xin-feng, WEI Zhi-mei, LIU Gui-yan, GAO Yan-hui, YU Xin-fa, CHEN Si-dong, LIU Li. Association analysis between genetic variants in STAT4and pathological characteristics of primary liver cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(8): 992-997. doi: 10.16462/j.cnki.zhjbkz.2019.08.021

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Association analysis between genetic variants in STAT4and pathological characteristics of primary liver cancer

doi: 10.16462/j.cnki.zhjbkz.2019.08.021

1.
Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China
2.
Department of Oncology, Shunde Hospital of Southern Medical University, Foshan 528300, China

Funds:

Natural Science Foundation of Guangdong Province 2016A030313809

Pearl River Nova Program of Guangzhou Science and Technology Project 201806010103

More Information

Corresponding author: LIU Li. E-mail: pupuliu919@163.com
Received Date: 2018-12-29
Rev Recd Date: 2019-04-02
Publish Date: 2019-08-10

Abstract

Abstract

Objective To investigate the effect of genetic variants in STAT4 and its interaction with exercise on the pathological characteristics of patients with liver cancer. Methods In the 601 new patients with primary liver cancer, multivariate Logistic regression model was used to analyze the genetic association with the risks of advanced stage and portal vein tumor thrombosis at first diagnosis for patients. The multiplicative interaction term and the "Delta" method were used to evaluate the multiplicative and additive interactions, respectively. Results Under the dominant model, the rs897200 variant showed a marginally statistical association with the risk of advanced liver cancer at first diagnosis for patients (adjusted OR=0.64, 95% CI: 0.41-1.01, P=0.057). Carriers of the rs1031507 CC+AC genotype had a lower risk of advanced liver cancer than those with the AA genotype (adjusted OR=0.63, 95% CI: 0.40-0.99, P=0.046). In the crossover analysis, compared with the patients who carried the rs897200 CT+CC genotype and had exercise, the TT genotype carriers being lack of exercise showed an increased risk of advanced cancer (OR=3.71, 95% CI: 1.97-6.98, P < 0.001). Similarly, the rs1031507 AA genotype and the lack of exercise jointly increased the risk of advanced cancer (OR=3.78, 95% CI: 2.01-7.13, P < 0.001). However, no statistical interactions between the genetic factors and exercise were observed for liver cancer stages. Conclusion The genetic variants in STAT4, rs897200 and rs1031507, solely or jointly with exercise, affect the clinical stage of liver cancer at patients' first diagnosis.
- STAT4,
- Primary liver cancer,
- Genetic variants,
- TNM stage,
- Portal vein cancer thrombus

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References(19)

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