Evaluation of individualized medication under the guidance of genetic testing in the management of hypertension patients in rural areas

NI Xiao-li; TANG Quan-qi; ZOU Shi-gui; LI Lun-lan; ZHANG Sheng-quan

doi:10.16462/j.cnki.zhjbkz.2019.10.024

Volume 23 Issue 10

Oct. 2019

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2019 > 23(10): 1284-1288

NI Xiao-li, TANG Quan-qi, ZOU Shi-gui, LI Lun-lan, ZHANG Sheng-quan. Evaluation of individualized medication under the guidance of genetic testing in the management of hypertension patients in rural areas[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(10): 1284-1288. doi: 10.16462/j.cnki.zhjbkz.2019.10.024

Citation:

NI Xiao-li, TANG Quan-qi, ZOU Shi-gui, LI Lun-lan, ZHANG Sheng-quan. Evaluation of individualized medication under the guidance of genetic testing in the management of hypertension patients in rural areas[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(10): 1284-1288. doi: 10.16462/j.cnki.zhjbkz.2019.10.024

Citation:

NI Xiao-li, TANG Quan-qi, ZOU Shi-gui, LI Lun-lan, ZHANG Sheng-quan. Evaluation of individualized medication under the guidance of genetic testing in the management of hypertension patients in rural areas[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(10): 1284-1288. doi: 10.16462/j.cnki.zhjbkz.2019.10.024

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Evaluation of individualized medication under the guidance of genetic testing in the management of hypertension patients in rural areas

doi: 10.16462/j.cnki.zhjbkz.2019.10.024

1.
Nursing Department, Anhui First Affiliated Hospital of Anhui Medical University, Hefei 230000, China
2.
Department of Cardiology, People's Hospital of Lujiang County, Anhui Medical University, Hefei 231500, China
3.
Department of Oncology, People's Hospital of Lujiang County, Hefei 231500, China
4.
Nursing Department, People's Hospital of Lujiang County, Hefei 231500, China
5.
Department of Basic Medical Sciences, Anhui Medical University, Hefei 230000, China

Funds:

Natural Science Research Project of Anhui Province KJ2017A195

More Information

Corresponding author: LI Lun-lan, E-mail: lilunlan@aliyun.com
Received Date: 2019-06-17
Rev Recd Date: 2019-09-03
Publish Date: 2019-10-10

Abstract

Abstract

Objective This study combined genotyping with family doctors' contracting model to assess the application of precision medicine in rural patients with essential hypertension. Methods In this study, 209 hypertensive patients from 3 villages in Lujiang County, Hefei City, Anhui Province were selected as subjects and randomly divided into experimental group(n=105) and control group(n=104). The medication regimen of observation group was guided by genetic testing for gene sensitivity to antihypertensive drugs, and the control group was implemented routine pharmacy. All the patients were managed by family doctors. Adverse drug reaction rate, treatment compliance, blood pressure, body mass index (BMI), fasting blood glucose (FBG), cholesterol (TC), and triglycerides (TG) of the two groups were analyzed, respectively, during the 6-month intervention. Results After 6-month of intervention, the medication compliance of the experimental group were significantly higher than that of the control group, and the blood pressure and adverse drug reaction rate were significantly lower than that of the control group. After 3 months of intervention, there was no significant decrease in BMI, FBG, TC and TG in the two groups. After 6 months of intervention, the FBG, TC and TG of the experimental group were significantly decreased, while only the FBG value of the control group was significantly decreased. There were no significant changes in body mass index (BMI) values in both groups. Conclusions Individualized medication guided by genotyping can improve the treatment compliance, reduce the adverse drug reaction rate, and improve the treatment efficiency of patients with essential hypertension.
- Gene test,
- Family doctors contracted services,
- Rural areas,
- Essential hypertension

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References(12)

References

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