Comparison of antibiotic resistance spectrum between methicillin-resistant and methicillin-susceptible coagulase-negative staphylococci nasal isolates among 1 001 HIV infectors

HE Sui-ping; YE Jia-ping; BAI Chan; LI Ling-hua; LI Li-ya; CAI Wei-ping; WANG Ying-ying; LI Ying; ZHANG Wen-cui; LIU Ning; GONG Zi-jun; YAO Zhen-jiang

doi:10.16462/j.cnki.zhjbkz.2019.12.018

Volume 23 Issue 12

Dec. 2019

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2019 > 23(12): 1527-1530

HE Sui-ping, YE Jia-ping, BAI Chan, LI Ling-hua, LI Li-ya, CAI Wei-ping, WANG Ying-ying, LI Ying, ZHANG Wen-cui, LIU Ning, GONG Zi-jun, YAO Zhen-jiang. Comparison of antibiotic resistance spectrum between methicillin-resistant and methicillin-susceptible coagulase-negative staphylococci nasal isolates among 1 001 HIV infectors[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(12): 1527-1530. doi: 10.16462/j.cnki.zhjbkz.2019.12.018

Citation:

HE Sui-ping, YE Jia-ping, BAI Chan, LI Ling-hua, LI Li-ya, CAI Wei-ping, WANG Ying-ying, LI Ying, ZHANG Wen-cui, LIU Ning, GONG Zi-jun, YAO Zhen-jiang. Comparison of antibiotic resistance spectrum between methicillin-resistant and methicillin-susceptible coagulase-negative staphylococci nasal isolates among 1 001 HIV infectors[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(12): 1527-1530. doi: 10.16462/j.cnki.zhjbkz.2019.12.018

Citation:

HE Sui-ping, YE Jia-ping, BAI Chan, LI Ling-hua, LI Li-ya, CAI Wei-ping, WANG Ying-ying, LI Ying, ZHANG Wen-cui, LIU Ning, GONG Zi-jun, YAO Zhen-jiang. Comparison of antibiotic resistance spectrum between methicillin-resistant and methicillin-susceptible coagulase-negative staphylococci nasal isolates among 1 001 HIV infectors[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2019, 23(12): 1527-1530. doi: 10.16462/j.cnki.zhjbkz.2019.12.018

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Comparison of antibiotic resistance spectrum between methicillin-resistant and methicillin-susceptible coagulase-negative staphylococci nasal isolates among 1 001 HIV infectors

doi: 10.16462/j.cnki.zhjbkz.2019.12.018

1.
Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China
2.
Department of Infectious Diseases, Guangzhou No.8 People's Hospital, Guangzhou 510060, China

Funds:

Guangdong Science and Technology Plan Project 2014A020213013

More Information

Corresponding author: YAO Zhen-jiang, E-mail: zhjyao2001@yahoo.com
Received Date: 2019-08-17
Rev Recd Date: 2019-10-16
Publish Date: 2019-12-10

Abstract

Abstract

Objective We aimed to elucidate the prevalence and the antibiotic resistance spectrum of nasal coagulase-negative staphylococci (CoNS) colonization among HIV infectors in Guangzhou. Method After isolation and identification, all CoNS isolates were tested for the antibiotic susceptibility, and the antibiotic resistance genes. Result Among the 1 001 HIV infectors, the prevalence of CoNS and MRCoNS were 57.44% and 48.15%, respectively. The three predominant resistant antibiotics of MRCoNS isolates were penicillin, erythromycin and trimethoprim-sulfame thoxazole, while predominant detection rates of genes were Aac(6')-aph(2')、ermC and linA genes. The multidrug resistance rate of MRCoNS isolates were significantly higher than methicillin-susceptible coagulase-negative staphylococci (MSCoNS) isolates (80.69% versus 39.66%, P < 0.001, OR=6.36). Conclusions The prevalence and multidrug resistant rates of nasal colonization CoNS and MRCoNS are high among HIV infectors in Guangzhou. MRCoNS isolates were 6.36 times more likely to be of multidrug resistance than MSCoNS isolates.
- HIV infectors,
- Coagulase-negative staphylococci,
- Methicillin-resistant coagulase -negative staphylococci,
- Antibiotic resistance

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References(12)

References

[1]	Taramasso L, Tatarelli P, Di Biagio A. Bloodstream infections in HIV-infected patients[J]. Virulence, 2016, 7(3)320-328. DOI: 10.1080/21505594.2016.1158359.
[2]	Declercq S, Munter PD, Derdelinckx I, et al. Characteristics, causes, and outcome of 54 episodes of bloodstream infections in a cohort of HIV patients[J]. Infect Dis, 2015, 47(9): 611-617. DOI: 10.3109/23744235.2015.1033002.
[3]	Ghassabi F, Hashempour T, Moghadami M, et al. Bacterial etiology and antibiotic resistance pattern of septicemia in HIV and non-HIV patients admitted to tertiary care hospitals, Shiraz, South of Iran[J]. Cell Mol Biol (Noisy-le-grand), 2017, 63(9): 115-121. DOI: 10.14715/CMB/2017.63.9.20.
[4]	Sampanedonkor E, Badoe EV, Annan JA, et al. Colonisation of antibiotic resistant bacteria in a cohort of HIV infected children in Ghana[J]. Pan Afr Med J, 2017, 26: 60. DOI: 10.11604/pamj.2017.26.60.10981.
[5]	Becker K, Heilmann C, Peters G. Coagulase-negative staphylococci[J]. Clin Microbiol Rev, 2014, 27(4): 870-926. DOI: 10.1128/CMR.00109-13.
[6]	郑浩渠, 徐暐杰, 王莹莹, 等. 吸毒人员凝固酶阴性葡萄球菌的携带及耐药性[J]. 广东医学, 2018, 39(23): 3525-3533. DOI: 10.13820/j.cnki.gdyx.20181221.003. Zheng HQ, Xu WJ, Wang YY, et al. Carriage and antibiotic resistance of methicillin-resistant coagulase-negative staphylococci among drug users[J]. Guangdong Medical Journal, 2018, 39(23): 3525-3533. DOI: 10.13820/j.cnki.gdyx.20181221.003.
[7]	黄小斌, 李玲, 李顺铭, 等. 1178名健康人群耐甲氧西林凝固酶阴性葡萄球菌的携带及耐药性[J]. 现代预防医学, 2018, 45(5): 900-904. Huang XB, Li L, Li SM, et al. Carriage and antibiotic resistance of methicillin-resistant coagulase-negative staphylococcus aureus among 1178 healthy human[J]. Modern Preventive Medicine, 2018, 45(5): 900-904.
[8]	Trouillet-Assant S, Flammier S, Sapin A, et al. Mupirocin resistance in isolates of staphylococcus spp. from Nasal Swabs in a tertiary hospital in France[J]. J Clin Microbiol, 2015, 53(8): 2713-5. DOI: 10.1128/JCM.00274-15.
[9]	陈培培, 管婧, 麦颖, 等. 2015-2017年广东某医院细菌耐药性监测结果分析[J]. 中国感染与化疗杂志, 2019, 19(1): 77-83. DOI: 10.16718/j.1009-7708.2019.01.013. Chen PP, Guan J, Mai Y, et al. Results of bacterial resistance surveillance in a Guangdong hospital during 2015-2017[J]. Chin J Infect Chemother, 2019, 19(1): 77-83. DOI: 10.16718/j.1009-7708.2019.01.013.
[10]	Singh S, Dhawan B, Kapil A, et al. Coagulasenegative staphylococci causing blood stream infection at an Indian tertiary care hospital: Prevalence, antimicrobial resistance and molecular characterisation[J]. Indian J Med Microbiol, 2016, 34(4): 500-505. DOI: 10.4103/0255-0857.195374.
[11]	Nanoukon C, Argemi X, Sogbo F, et al. Pathogenic features of clinically significant coagulase-negative staphylococci in hospital and community infections in Benin[J]. Int J Med Microbiol, 2017, 307(1): 75-82. DOI: 10.1016/j.ijmm.2016.11.001.
[12]	Kitti T, Seng R, Saiprom N, et al. Molecular Characteristics of Methicillin-Resistant Staphylococci Clinical Isolates from a Tertiary Hospital in Northern Thailand[J]. Can J Infect Dis Med Microbiol, 2018, 2018: 1-7. DOI: 10.1155/2018/8457012.