Prevalence study of neurocognitive functions and modifiable risk factors in HIV-infected individuals

YUAN Shi-ying; CHEN Xiao-xiao; LIN Hai-jiang; SHI Rui-zi; LI Jing; XU Lu-lu; QIAO Shi-jie; DING Ying-ying; HE Na

doi:10.16462/j.cnki.zhjbkz.2020.12.001

Volume 24 Issue 12

Jan. 2021

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YUAN Shi-ying, CHEN Xiao-xiao, LIN Hai-jiang, SHI Rui-zi, LI Jing, XU Lu-lu, QIAO Shi-jie, DING Ying-ying, HE Na. Prevalence study of neurocognitive functions and modifiable risk factors in HIV-infected individuals[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1365-1370. doi: 10.16462/j.cnki.zhjbkz.2020.12.001

Citation:

YUAN Shi-ying, CHEN Xiao-xiao, LIN Hai-jiang, SHI Rui-zi, LI Jing, XU Lu-lu, QIAO Shi-jie, DING Ying-ying, HE Na. Prevalence study of neurocognitive functions and modifiable risk factors in HIV-infected individuals[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1365-1370. doi: 10.16462/j.cnki.zhjbkz.2020.12.001

Citation:

YUAN Shi-ying, CHEN Xiao-xiao, LIN Hai-jiang, SHI Rui-zi, LI Jing, XU Lu-lu, QIAO Shi-jie, DING Ying-ying, HE Na. Prevalence study of neurocognitive functions and modifiable risk factors in HIV-infected individuals[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1365-1370. doi: 10.16462/j.cnki.zhjbkz.2020.12.001

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Prevalence study of neurocognitive functions and modifiable risk factors in HIV-infected individuals

doi: 10.16462/j.cnki.zhjbkz.2020.12.001

1.
Department of Public Health Epidemiology, Fudan University, Key Laboratory of Public Health and Safety Education, Shanghai 200032, China
2.
Taizhou Center for Disease Control and Prevention, Taizhou 318000, China

Funds:

China National Science and Technology Major Projects on Infectious Diseases 2018ZX10721102-004

The 5^th Public Health Action Plan of Shanghai Municipal Health Commission 076478684Q/2020-00218

More Information

Corresponding author: HE Na, E-mail: nhe@fudan.edu.cn
Received Date: 2020-10-17
Rev Recd Date: 2020-11-06
Publish Date: 2020-12-10

Abstract

Abstract

Objective To investigate the effects of regulatory risk factors on neurocognitive function of human immunodeficiency virus infected persons. Methods Using the baseline survey data of the prospective cohort study of HIV and aging related diseases from 2018 to 2019, elderly HIV infected persons aged 40 and above were selected. A general linear model (GLM) was used to analyze the effects of regulatory risk factors including cardiovascular disease risk factors and bad life behavior on neurocognitive performance of infected persons. Results A total of 625 HIV infected persons were included in the study. Cardiovascular disease risk factors and bad life behavior were reported in the elderly HIV infected patients. At different age stages, the neurocognitive function of infected persons decreased to different degrees, and the cognitive function decreased significantly after 60 years of age. Multivariate regression analysis model showed that hypertension was a risk factor for orientation, memory, delayed recall, language function and exercise ability of infected persons, and other regulatory risk factors such as smoking, alcohol consumption, diabetes and abdominal obesity had not been statistically correlated. Moreover, after clinical grading analysis of blood pressure, it found that prehypertension was associated with decreased language function (β=-0.327, P=0.020), orientation force (β=-0.216, P=0. 028). Even if it did not develop to hypertension state, high-value blood pressure have a negative effect on neurocognitive function. Conclusions Hypertension is associated with the decline of neurocognitive function in middle-aged and elderly HIV patients, and orientation and language ability may be adversely affected in the early stage of hypertension. During HIV follow-up management in the future, we should strengthen the prevention and control of hypertension, early detection of hypertension and standardized clinical management.
- HIV,
- Neurocognitive functioning,
- Modifiable risk factors

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References(27)

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