Early treatment initiation post- HIV diagnosis may reduce care dropout

AN Jing; LOU Jin-cheng; YANG Gen; LAO Yun-fei

doi:10.16462/j.cnki.zhjbkz.2020.12.010

Volume 24 Issue 12

Jan. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(12): 1412-1417

AN Jing, LOU Jin-cheng, YANG Gen, LAO Yun-fei. Early treatment initiation post- HIV diagnosis may reduce care dropout[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1412-1417. doi: 10.16462/j.cnki.zhjbkz.2020.12.010

Citation:

AN Jing, LOU Jin-cheng, YANG Gen, LAO Yun-fei. Early treatment initiation post- HIV diagnosis may reduce care dropout[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1412-1417. doi: 10.16462/j.cnki.zhjbkz.2020.12.010

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Early treatment initiation post- HIV diagnosis may reduce care dropout

doi: 10.16462/j.cnki.zhjbkz.2020.12.010

AN Jing^{1, 2},
LOU Jin-cheng¹,
YANG Gen¹,
LAO Yun-fei^{1
,
,}

1.
Yunnan Provincial Infectious Disease Hospital, Yunnan AIDS Care Center, AIDS Clinical Management Office, Kunming 650301, China
2.
Kunming Medical University, School of Public Health, Kunming 650500, China

Funds:

Applied Basic Research Joint Special Fund Project of Kunming Medical University and Yunnan Provincial Department of Science and Technology 202001AY070001-105

More Information

Corresponding author: LAO Yun-fei, E-mail:laoyunfei@hotmail.com
Received Date: 2020-01-15
Rev Recd Date: 2020-07-23
Publish Date: 2020-12-10

Abstract

Abstract

Objective To analyze the effect of time interval from diagnosis of human immunodeficiency virus (HIV) to initiation of antiretroviral therapy (ART) on the dropout during treatment, and to provide reference for counseling on mobilization of ART. Methods COX regression was used to assess the risk of first dropout in patients with different time intervals. The data of 15- years ART in Yunnan Province were analyzed retrospectively. Results 110 373 cases of ART among people living with HIV in Yunnan from 2004 to 2018 were included in the analysis. the median time from the diagnosis of HIV to the start of ART was 47 (11 550) days, and the median follow-up was 2.63 (0.88, 5.28) years. Out of the total cases, 47 974 (43.5%) patients started ART within 30 days post-HIV-diagnosis, 15 811 (14.3%) patients had an interval of 31-90 days, 14 253 (12.9%) patients had an interval of 91-365 days, and 32 335 (29.3%) patients had an interval above 365 days. The total dropout rate was 6.77/100 person-years (95% CI:6.69-6.85). With the < 30 day group as the reference, the dropout risk in the 30-90 day group, the 91-365 day group and the >365 day group increased by 10%, 22% and 14%, respectively. In the groups of < 30- day, the 30-90 day, the 91-365 day and the >365 day, the cumulative dropout rates were respectively 11.4%, 12.7%, 15.0% and 15.7%. Conclusions Real-world data confirmed that shortening the time interval from HIV diagnosis to ART initiation (preferably within 30 days) can reduce treatment dropout. The results support the implementation of "one-stop AIDS testing and treatment service" as a prevention and treatment measure. This study provides powerful suggestions for Yunnan Province to guide the mobilization of treatment counseling.
- HIV/AIDS,
- Antiretroviral therapy,
- Treatment dropout

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References(22)

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