A case-control study on the relationship between maternal copper and preeclampsia

GAO Lin-ying; WANG Ying; WU Wei-wei; FENG Yong-liang; YANG Hai-lan; WANG Su-ping

doi:10.16462/j.cnki.zhjbkz.2020.12.016

Volume 24 Issue 12

Jan. 2021

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GAO Lin-ying, WANG Ying, WU Wei-wei, FENG Yong-liang, YANG Hai-lan, WANG Su-ping. A case-control study on the relationship between maternal copper and preeclampsia[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1447-1451. doi: 10.16462/j.cnki.zhjbkz.2020.12.016

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GAO Lin-ying, WANG Ying, WU Wei-wei, FENG Yong-liang, YANG Hai-lan, WANG Su-ping. A case-control study on the relationship between maternal copper and preeclampsia[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1447-1451. doi: 10.16462/j.cnki.zhjbkz.2020.12.016

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A case-control study on the relationship between maternal copper and preeclampsia

doi: 10.16462/j.cnki.zhjbkz.2020.12.016

1.
School of Public Health, Shanxi Medical University, Taiyuan 030001, China
2.
Department of Obstetrics, First Hospital of Shanxi Medical University, Taiyuan 030001, China

Funds:

National Natural Science Foundation of China 81703314

Doctoral Startup Research Fund of Shanxi Medical University 03201615

More Information

Corresponding author: WU Weiwei, E-mail:wuweiwei2008@sina.com
Received Date: 2020-06-16
Rev Recd Date: 2020-09-01
Publish Date: 2020-12-10

Abstract

Abstract

Objective To investigate the level of copper (Cu) in pregnant women with preeclampsia and normotensive pregnant women, and their relationship with risk of preeclampsia. Methods A frequency matching case-control study was performed among the pregnant women who gave birth between March 2012 and September 2016 in the First Hospital of Shanxi Medical University. A total of 427 pregnant women with preeclampsia were as cases. 427 normotensive pregnant women matched for date of conception, residence, and age were randomly selected as controls. Demographic characteristics, childbearing history, pregnancy and health condition, behavior and lifestyle, family history of hypertension, and newborn birth condition were collected by face to face investigation and medical records review. Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine levels of copper, manganese, zinc, and selenium in the maternal blood. Results The distribution of maternal blood copper was skewed, and the median and inter-quartile range of copper concentration in the preeclampsia and control group were 1.31(1.07, 1.60) mg/L and 1.31(1.06, 1.56) mg/L (Z=0.41, P=0.685). The median and quartile values of blood Cu in pregnant women with early and late preeclampsia were 1.25 (1.04, 1.56) mg/L and 1.34 (1.08, 1.61) mg/L (Z=1.78, P=0.075), respectively. There were no significant differences in blood Cu levels between the preeclampsia group, the control group and the pre-eclampsia group with different clinical subtypes (all P > 0.05). The results of Logistic regression analysis model showed that after the control of the level of education, income, pre-pegant body mass index, pregnancy weight gain, parity, gestational diabetes, family history of high blood pressure, and other elements, such as pregnant women were not found in the blood Cu with preeclampsia, early onset preeclampsia, and later in the pathogenesis of preeclampsia. Conclusions It can not be considered that maternal blood copper is related with preeclampsia and its subtypes.
- Preeclampsia,
- Copper,
- Pregnant women,
- Case-control study

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References(19)

References

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