HIV-1 epidemic strains and genetic variation among therapy-naive men who have sex with men

LU Xin-li; ZHANG Yu-qi; QIU Yan-chao; LI Bao-jun; LI Yan; WANG Ying-ying; LIU Meng; AN Ning

doi:10.16462/j.cnki.zhjbkz.2020.12.019

Volume 24 Issue 12

Jan. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2020 > 24(12): 1465-1469

LU Xin-li, ZHANG Yu-qi, QIU Yan-chao, LI Bao-jun, LI Yan, WANG Ying-ying, LIU Meng, AN Ning. HIV-1 epidemic strains and genetic variation among therapy-naive men who have sex with men[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1465-1469. doi: 10.16462/j.cnki.zhjbkz.2020.12.019

Citation:

LU Xin-li, ZHANG Yu-qi, QIU Yan-chao, LI Bao-jun, LI Yan, WANG Ying-ying, LIU Meng, AN Ning. HIV-1 epidemic strains and genetic variation among therapy-naive men who have sex with men[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1465-1469. doi: 10.16462/j.cnki.zhjbkz.2020.12.019

Citation:

LU Xin-li, ZHANG Yu-qi, QIU Yan-chao, LI Bao-jun, LI Yan, WANG Ying-ying, LIU Meng, AN Ning. HIV-1 epidemic strains and genetic variation among therapy-naive men who have sex with men[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2020, 24(12): 1465-1469. doi: 10.16462/j.cnki.zhjbkz.2020.12.019

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HIV-1 epidemic strains and genetic variation among therapy-naive men who have sex with men

doi: 10.16462/j.cnki.zhjbkz.2020.12.019

1.
Department of AIDS Research, Hebei Key Laboratory of Pathogen and Epidemiology of Infectious Disease, Hebei Provincial Center for Disease Control and Prevention, Shijiazhuang 050021, China
2.
Department of AIDS Research, Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang 050011, China

Funds:

Provincial Natural Science Foundation of Hebei H2016303006

More Information

Corresponding author: LU Xinli, E-mail:lxlii2009@163.com
Received Date: 2020-09-30
Rev Recd Date: 2020-11-04
Publish Date: 2020-12-10

Abstract

Abstract

Objective To explore HIV-1 genotypes and genetic variation among therapy-naive men who have sex with men (MSM) in Shijiazhuang. Methods HIV-1 genotypic resistance assay was carried out using In-house method. HIV-1 genotypes and drug resistance were analyzed by phylogenetic analysis and submitting the sequences to the Stanford University Network HIV-1 database. Results Five HIV-1 subtypes were found among MSM in Shijiazhuang. Of them, CRF01_AE was the most frequent, accounting for 56.8% (25/44), followed by CRF07_BC 29.5% (13/44), URFs 9.1% (4/44), B 2.3% (1/44) and CRF55_01B 2.3% (1/44). URFs mainly included CRF01_AE/B and CRF01_AE/C. χ² -test verified that HIV-1 genotype distribution showed significant difference (P < 0.05) in marital status, age and first CD4 groups, respectively. The rate of HIV-1 primary drug resistance was 2.3% (1/44). P225H mutation was found in NNRT gene coding region, and one MSM with P225H occurred intermediate resistance to EFV and NVP. Conclusion It is critical for us to take measures to monitor HIV-1 epidemic and drug resistance.
- Human immunodeficiency virus type one,
- Genotype,
- Men who have sex with men,
- Mutation

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References(10)

References

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