The study of periconception folic acid supplementation and its relationship with pregnancy outcome

CHEN Gan-ne; JIANG Min; HUANG Wei-wen; ZHAO Xin-jie; LIU Yun-hui; HUANG Wan-ping

doi:10.16462/j.cnki.zhjbkz.2021.02.008

Volume 25 Issue 2

Feb. 2021

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(2): 160-164

CHEN Gan-ne, JIANG Min, HUANG Wei-wen, ZHAO Xin-jie, LIU Yun-hui, HUANG Wan-ping. The study of periconception folic acid supplementation and its relationship with pregnancy outcome[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(2): 160-164. doi: 10.16462/j.cnki.zhjbkz.2021.02.008

Citation:

CHEN Gan-ne, JIANG Min, HUANG Wei-wen, ZHAO Xin-jie, LIU Yun-hui, HUANG Wan-ping. The study of periconception folic acid supplementation and its relationship with pregnancy outcome[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(2): 160-164. doi: 10.16462/j.cnki.zhjbkz.2021.02.008

Citation:

CHEN Gan-ne, JIANG Min, HUANG Wei-wen, ZHAO Xin-jie, LIU Yun-hui, HUANG Wan-ping. The study of periconception folic acid supplementation and its relationship with pregnancy outcome[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(2): 160-164. doi: 10.16462/j.cnki.zhjbkz.2021.02.008

PDF( 784 KB)

The study of periconception folic acid supplementation and its relationship with pregnancy outcome

doi: 10.16462/j.cnki.zhjbkz.2021.02.008

1.
Department of Health, Guangzhou Huadu District Maternal and Child Health Hospital, Guangzhou Huadu District, Guangzhou 510800, China
2.
Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University, Chengdu 610041, China

Funds:

Key R & D project of Sichuan Science and Technology Department 2019YFS0409

Guangzhou Scientific Research Special Project 201707010239

General Medical Research Project of Huadu District 19-HDWS-082

More Information

Corresponding author: CHEN Gan-ne, E-mail: 64530286@qq.com
Received Date: 2020-06-01
Rev Recd Date: 2020-08-18
Publish Date: 2021-02-10

Abstract

Abstract

Objective This study aimed to investigate the situation and dosage of penconception folic acid supplementation and to explore the association between periconception folic acid supplementation and pregnancy outcome. Methods A total of 6 526 pregnant women were recruited from October 2017 to June 2019 in Huadu District of Guangzhou. R retrospective surveys before or after delivery were conducted to collect information about general demographic characteristics, periconception folic acid supplementationand pregnancy outcomes. Results There were 1 345 pregnant women (20.18%) taken folic acid for more than one month at half a year before pregnancy. 764(11.69%) pregnant women took normal daily dosage of folic acid during periconception. Preconception folic acid supplementation was associated with 74.68 g higher birth weight and the first-trimester supplementation increased 55.05 g (P < 0.05), compared to no folic acid supplementation. After adjusted maternal age, educational level, pre-gestational body mass index (BMI), passive smoking time, periconception folic acid supplementation could reduced the risk of small for gestational age (SGA) infants (aOR=0.66; 95% CI: 0.46-0.95). Low birth weight (LBW) and spontaneous preterm delivery were not related to the type of folic acid supplementation. High-dose folic acid during periconception may increased the risk of spontaneous preterm (aOR=1.75; 95% CI: 1.02-3.01). SGA and LBW were not related to folic acid dose. Conclusions Periconception folic acid supplementation was positively associated with fetal growth resulting in birth weight, and decreased risks of SGA.
- Folate,
- Birth weight,
- Pregnancy outcome

FullText(HTML)

References(20)

References

[1]	Yu J, Flatley C, Greer RM, et al. Birth-weight centiles and the risk of serious adverse neonatal outcomes at term[J]. J Perinat Med, 2018, 46(9):1048-1056. DOI: 10.1515/jpm-2017-0176.
[2]	Anderson SE, Mcnamara K, Andridge R, et al. Executive function and mealtime behavior among preschool-aged children born very preterm[J]. Eat Behav, 2015, 19(12):110-114. DOI: 10.1016/j.eatbeh.2015.07.006.
[3]	Gur Z, Tsumi E, Wainstock T, et al. Association between delivery of small-for-gestational age neonate and long-term pediatric ophthalmic morbidity[J]. Arch Gynecol and Obstet, 2018, 298(6):1095-1099. DOI: 10.1007/s00404-018-4901-7.
[4]	赵曼丽.孕早期血清叶酸、同型半胱氨酸水平检测的临床意义及预防妊娠并发症、胎儿出生缺陷的临床疗效分析[J].中国妇幼保健, 2019, 34(6):1249-1251. DOI: 10.7620/zgfybj.j.issn.1001-4411.2019.06.13. Zhao ML. Clinical significance of serum folic acid homocysteine levels in early pregnancy and prevention of pregnancy complications Clinical effect analysis of fetal birth defects[J]. Maternal and Child Health Care of China, 2019, 34(6):1249-1251. DOI: 10.7620/zgfybj.j.issn.1001-4411.2019.06.13.
[5]	任爱国.叶酸预防神经管缺陷[J].北京大学学报(医学版), 2014, (3):343-346. DOI: 10.3969/j.issn.1671-167x.2014.03.002. Ren AG. Folic acid prevents neural tube defects[J]. Journal of Peking University (Medical Edition), 2014, (3):343-346. DOI: 10.3969/j.issn.1671-167x.2014.03.002.
[6]	Li Z, Ye R, Zhang L, et al. Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study[J]. Int J Epidemio, 2014, 43(4):1113-1132.DOI: 10.1093/ije/dyu020.
[7]	Zheng JS, Guan Y, Zhao Y, et al. Pre-conceptional intake of folic acid supplements is inversely associated with risk of preterm birth and small-for-gestational-age birth a prospective cohort study[J]. Brit J Nutr, 2016, 115(3):509-516. DOI: 10.1017/S0007114515004663.
[8]	李佳媚, 屈鹏飞, 党少农, 等.陕西省育龄妇女围孕期增补叶酸对新生儿出生体重的影响[J].中华流行病学杂志, 2016, 37(7):1017-1020. DOI: 10.3760/cma.j.issn.0254-6450.2016.07.022. Li JM, Qu PF, Dang SN, et al. Effect of folic acid supplementation in childbearing aged women during pregnancy on neonate birth weight in Shaanxi province[J]. Chin J Epidemiol, 2016, 37(7):1017-1020. DOI: 10.3760/cma.j.issn.0254-6450.2016.07.022.
[9]	朱丽.中国不同胎龄新生儿出生体重曲线研制[J].中华儿科杂志, 2015, 2(53):97-103. DOI: 10.3760/cma.Jissn.0578.1310.2015.02.007. Zhu L. Chinese neonatal birth weight curve for different gestational age[J]. Chin J Pediatr, 2015, 2(53):97-103. DOI: 10.3760/cma.Jissn.0578.1310.2015.02.007.
[10]	Bukowski R, Malone FD, Porter FT, et al. Preconceptional folate supplementation and the risk of spontaneous preterm birth a cohort study[J]. PLos Med, 2009, 6(5):e1000061. DOI: 10.1371/journal.pmed.1000061.
[11]	Fueness DF, Yasin N, Dekker GA, et al. Maternal red blood cell folate concentration at 10-12 weeks gestation and pregnancy outcome[J]. J Mater Fetal Neo M, 2012, 25(8):1142-1423. DOI: 10.3109/14767058.2011.636463.
[12]	谢幸, 孔北华, 段涛.妇产科学[M].第9版.北京:人民卫生出版社, 2018:43-43. Xie X, Kong BH, Duan T. Obstetrics and gynecology[M]. 9th ed. Beijing: People's Medical Publishing House, 2018:43-43.
[13]	Xing X, Tao F, Hao J, et al. Periconceptional folic acid supplementation among women attending antenatal clinic in Anhui, China: data from a population-based cohort study[J]. Midwifery, 2012, 28(3):291-297. DOI: 10.1016/j.midw.2011.04.002.
[14]	Liu J, Jin L, Meng Q, et al. Changes in folic acid supplementation behaviour among women of reproductive age after the implementation of a massive supplementation programme in China[J]. Public Health Nutr, 2015, 18(4):582-588. DOI: 10.1017/S1368980014000950.
[15]	陈京, 张世琨, 王巧梅, 等. 2010至2012年中国农村孕早期妇女叶酸服用状况调查[J].中华医学杂志, 2016, 96(15):1215-1219. DOI: 10.3760/cma.j.issn.0376-2491.2016.15.016. Chen J, Zhang SK, Wang QM, et al. Investigation on folic acid supplementation status among Chinese women in the first trimester of pregnancy[J]. Natl Med J Chin, 2016, 96(15):1215-1219. DOI: 10.3760/cma.j.issn.0376-2491.2016.15.016.
[16]	Relton CL, Pearce MS, Parker L. The influence of erythrocyte folate and serum vitamin B-12 status on birth weight[J]. Br J Nutr, 2005, 93(5):593-599. DOI: 10.1079/BJN20041395.
[17]	Hodgetts VA, Morris RK, Francis A, et al. Effectiveness of folic acid supplementation in pregnancy on reducing the risk of small-for-gestational age neonates: a population study, systematic review and meta-analysis[J]. Bjog-Int J Obstet Gy, 2015, 122(4):478-490. DOI: 10.1111/1471-0528.13202.
[18]	Sengpiel V, Bacelis J, Myhre R, et al. Folic acid supplementation, dietary folate intake during pregnancy and risk for spontaneous preterm delivery: a prospective observational cohort study[J]. BMC Pregnancy Childb, 2014, 14(1):375-388. DOI: 10.1186/s12884-014-0375-1.
[19]	郭华棋.围孕期叶酸摄入方式对早产、低出生体重和小于胎龄儿的影响研究[D].兰州: 兰州大学, 2018. Guo HQ. The effect of folic acid intake on preterm birth, low birth weight and small gestational age during the perinatal period[D]. Lanzhou: Lanzhou University, 2018.
[20]	Christian P. Micronutrients, birth weight, and survival[J]Annu Rev Nutr, 2010: 83-104. DOI: 10.1146/annurev.nutr.012809.104813.