Effectiveness of <i>Haemophilus</i> <i>influenzae</i> type b conjugate vaccine on hospitalized pneumonia among children in Suzhou: an observational study

DAI Zi-rui; LUAN Lin; TIAN Jian-mei; XU Xin-xin; LIN Yu-zun; ZHENG Ben-feng; FENG Shuang; LIU Chang-peng; ZHANG Jun; ZHANG Tao; ZHAO Gen-ming

doi:10.16462/j.cnki.zhjbkz.2021.02.014

Volume 25 Issue 2

Feb. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(2): 192-197

DAI Zi-rui, LUAN Lin, TIAN Jian-mei, XU Xin-xin, LIN Yu-zun, ZHENG Ben-feng, FENG Shuang, LIU Chang-peng, ZHANG Jun, ZHANG Tao, ZHAO Gen-ming. Effectiveness of Haemophilus influenzae type b conjugate vaccine on hospitalized pneumonia among children in Suzhou: an observational study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(2): 192-197. doi: 10.16462/j.cnki.zhjbkz.2021.02.014

Citation:

DAI Zi-rui, LUAN Lin, TIAN Jian-mei, XU Xin-xin, LIN Yu-zun, ZHENG Ben-feng, FENG Shuang, LIU Chang-peng, ZHANG Jun, ZHANG Tao, ZHAO Gen-ming. Effectiveness of Haemophilus influenzae type b conjugate vaccine on hospitalized pneumonia among children in Suzhou: an observational study[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(2): 192-197. doi: 10.16462/j.cnki.zhjbkz.2021.02.014

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Effectiveness of Haemophilus influenzae type b conjugate vaccine on hospitalized pneumonia among children in Suzhou: an observational study

doi: 10.16462/j.cnki.zhjbkz.2021.02.014

1.
Department of Epidemiology School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education, Shanghai 200032, China
2.
Department of Prevention and Control, Suzhou Center for Disease Control and Prevention, Suzhou 215004, China
3.
Soochow University Affiliated Children's Hospital, Suzhou 215003, China

Funds:

Three-year Action Plan (2020-2022) and Key Discipline Program on Public Health System Construction of Shanghai GWV-10.1-XK16

Global Influenza Hospital Surveillance Network CN2018/2019

More Information

Corresponding author: ZHAO Gen-ming, E-mail:gmzhao@shmu.edu.cn
Received Date: 2020-09-02
Rev Recd Date: 2020-11-09
Publish Date: 2021-02-10

Abstract

Abstract

Objective To evaluate the vaccine effectiveness (VE) of different doses of Haemophilus influenzae type b (Hib) conjugate vaccine on hospitalized pneumonia among children. Methods A retrospective cohort study was conducted among local children born in 2018 and admitted to Suzhou University Affiliated Children's Hospital. Hospital records were collected by using Hospital Information System and vaccination information were identified through Suzhou CDC's electronic vaccine registry database before Jun 30, 2019. The incidence rates of hospitalized pneumonia among vaccinated and children with different doses unvaccinated children were compared and VE was calculated. Results Hib vaccination coverage of ≥1-dose was 18.8%(10 080/53 753)among children in Suzhou between Jan 1, 2018 to Jun 30, 2019. The incidence rates of hospitalized pneumonia decreased with the increase of doses of Hib vaccine (χ²=-4.31, P < 0.001), and the protective effects of 1-dose and 2-doses Hib vaccine were not found, but 2-doses Hib vaccine showed a trend of protection. The incidence rate of hospitalized pneumonia among children who received ≥3-doses Hib vaccine was lower than unvaccinated children (RR=0.72, 95% CI: 0.59-0.89, P < 0.001), and the incidence rate of vaccine-preventable hospitalized pneumonia was 1 514.8 per 10⁵ person-years, and VE of ≥3- doses was 28% (95% CI: 11%-41%). Conclusions Incidence rate of hospitalized pneumonia among children in Suzhou can be reduced by ≥3- doses Hib vaccination. It is suggested that Hib vaccination should be further promoted in children to increase the Hib vaccination coverage.
- Children,
- Hospitalized pneumonia,
- Haemophilus influenzae type b conjugate vaccine,
- Vaccine effectiveness

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References(26)

References

[1]	宁桂军, 王旭霞, 刘世文, 等. 2015-2016年甘肃省白银市5岁以下儿童社区获得性肺炎疾病负担回顾性调查[J].中国疫苗和免疫, 2017, 23(1):18-21. http://www.cnki.com.cn/Article/CJFDTotal-ZGJM201701004.htm Ning GJ, Wang XX, Liu SW, et al. Retrospective investigation of the disease burden of community acquired pneumonia among children under 5 years old in Baiyin City of Gansu Province, 2015-2016[J]. Chin J Vaccin Immun, 2017, 23(1):18-21. http://www.cnki.com.cn/Article/CJFDTotal-ZGJM201701004.htm
[2]	王喆, 季伟, 郭红波, 等.儿童社区与院内获得性肺炎的细菌病原构成及其耐药性对比研究[J].中华预防医学杂志, 2011(3):211-216. DOI: 10.3760/cma.j.issn.0253-9624.2011.03.005. Wang Z, Ji W, Guo HB, et al. Comparative studies on the composition and antibiotic-resistance of pathogenic bacteria between children with community-acquired and hospital-acquired pneumonia[J]. Chin J Pre Med, 2011(3):211-216. DOI: 10.3760/cma.j.issn.0253-9624.2011.03.005.
[3]	张蕾, 艾涛, 杨亚静, 等.儿童社区获得性肺炎病原菌分析[J].中国感染控制杂志, 2014, 13(1):50-52. DOI: 10.3969/j.issn.1671-9638.2014.01.013. Zhang L, Ai T, Yang YJ, et al. Analysis on pathogenic bacteria causing community-associated pneumonia in children[J]. Chin J Infect Control, 2014, 13(1):50-52. DOI: 10.3969/j.issn.1671-9638.2014.01.013.
[4]	World Health Organization.Pneumonia[EB/OL].(2019-08- 02)[2020-07-05].https://www.who.int/en/news-room/fact-sheets/detail/pneumonia.
[5]	中华医学会儿科学分会感染学会, 中国儿童感染性疾病病原学及细菌耐药检测协作组, 中华儿科杂志编辑委员会.儿童流感嗜血杆菌感染诊断及治疗专家建议[J].中华儿科杂志, 2019, 57(9):663-668. DOI: 10.3760/cma.j.issn.0578-1310.2019.09.004. The Subspeciality Group of Infectious Diseases, the Society of Pediatrics, Chinese Medical Association, the Group of Infectious Disease Surveillance of Pediatrics, the Editorial Board, Chinese Journal of Pediatrics. Expert consensus on diagnosis and treatment of Haemophilus influenzae infection in children[J]. Chin J Pediatr, 2019, 57(9):663-668. DOI: 10.3760/cma.j.issn.0578-1310.2019.09.004.
[6]	World Health Organization. Haemophilus influenzae type b (Hib) Vaccination WHO position paper: July 2013-Recommendations[J]. Vaccine, 2013, 31(52):6168-6169. DOI: 10.1016/j.vaccine.2013.10.045.
[7]	Wahl B, O'Brien KL, Greenbaum A, et al. Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000-15[J]. Lancet Glob Health, 2018, 6(7):e744-e757. DOI: 10.1016/S2214-109X(18)30247-X.
[8]	朱启镕, 杨永弘, 刁连东.中国b型流感嗜血杆菌疾病及其免疫预防研讨会会议纪要[J].中华传染病杂志, 2005, (6):434. DOI: 10.3760/j.issn:1000-6680.2005.06.023. Zhu QR, Yang YH, Diao LD. Minutes of Chinese Haemophilus influenzae type b disease and immunization prevention seminar[J]. Chin J Infect Dis, 2005, (6):434. DOI: 10.3760/j.issn:1000-6680.2005.06.023.
[9]	le Roux DM, Zar HJ. Community-acquired pneumonia in children-a changing spectrum of disease[J]. Pediatrc Radiol, 2017, 47(11):1392-1398. DOI: 10.1007/s00247-017-3827-8.
[10]	Rudan I, O'Brien KL, Nair H, et al. Epidemiology and etiology of childhood pneumonia in 2010: estimates of incidence, severe morbidity, mortality, underlying risk factors and causative pathogens for 192 countries[J]. J Glob Health, 2013, 3(1):010401. DOI: 10.7189/jogh.03.010401.
[11]	Chongmelaxme B, Hammanee M, Phooaphirak W, et al. Economic evaluations of Haemophilus influenzae type b (Hib) vaccine:a systematic review[J]. J Med Econ, 2017, 20(10):1094-1106. DOI: 10.1080/13696998.2017.1359181.
[12]	Mulholland K, Hilton S, Adegbola R, et al. Randomised trial of Haemophilus influenzae type-b tetanus protein conjugate for prevention of pneumonia and meningitis in Gambian infants[J]. Lancet, 1997, 349(9060):1191-1197. DOI: 10.1016/s0140-6736(96)09267-7.
[13]	Levine OS, Lagos R, Muñoz A, et al. Defining the burden of pneumonia in children preventable by vaccination against Haemophilus influenzae type b[J]. Pediatr Infect Dis J, 1999, 18(12):1060-1064. DOI: 10.1097/00006454-199912000-00006.
[14]	de Andrade AL, de Andrade JG, Martelli CM, et al. Effectiveness of Haemophilus influenzae b conjugate vaccine on childhood pneumonia: a case-control study in Brazil[J]. Int J Epidemiol, 2004, 33(1):173-181. DOI: 10.1093/ije/dyh025.
[15]	de la Hoz F, Higuera AB, Di Fabio JL, et al. Effectiveness of Haemophilus influenzae type b vaccination against bacterial pneumonia in Colombia[J]. Vaccine, 2004, 23(1):36-42. DOI: 10.1016/j.vaccine.2004.05.017.
[16]	Yang Y, Pan X, Cheng W, et al. Haemophilus influenzae type b carriage and burden of its related diseases in Chinese children: systematic review and meta-analysis[J]. Vaccine, 2017, 35(46):6275-6282. DOI: 10.1016/j.vaccine.2017.09.057.
[17]	钱晓华, 王传清, 朱启镕, 等.社区儿童接种b型流行性感冒嗜血杆菌结合疫苗的前瞻性队列研究[J].中国疫苗和免疫, 2010, 16(2):157-160. http://qikan.cqvip.com/Qikan/Article/Detail?id=33905662 Qian XH, Wang CQ, Zhu QR, et al. A prospective cohort study on community children vaccinated with haemophilus influenzae type b[J]. Chin J Vaccin Immun, 2010, 16(2):157-160. http://qikan.cqvip.com/Qikan/Article/Detail?id=33905662
[18]	Gray DM, Turkovic L, Willennse L, et al. Lung function in African infants in the drakenstein child health study. Impact of lower respiratory tract illness[J]. Am J Respir Crit Care Med, 2017, 195(2):212-220. DOI: 10.1164/rccm.201601-0188OC.
[19]	Edmond K, Scott S, Korczak V, et al. Long term sequelae from childhood pneumonia; systematic review and meta-analysis[J]. PLoS One, 2012, 7(2):e31239. DOI: 10.1371/journal.pone.0031239.
[20]	倪虹, 刘海鹏, 崔伟, 等.安徽某医院2013-2017年住院儿童疾病谱变化研究[J].中华疾病控制杂志, 2019, 23(2):238-241. DOI: 10.16462/j.cnki.zhjbkz.2019.02.023. Ni H, Liu HP, Cui W, et al. Trend of disease spectrum of hospitalized children in Anhui provincial children's hospital from 2013 to 2017[J]. Chin J Dis Prev, 2019, 23(2):238-241. DOI: 10.16462/j.cnki.zhjbkz.2019.02.023.
[21]	陈奕, 许国章, 马瑞, 等. 2009-2012年浙江省宁波市5岁以下住院儿童肺炎发病情况及病原学特征[J].中华预防医学杂志, 2014, 48(12):1053-1056. DOI: 10.3760/cma.j.issn.0253-9624.2014.12.007. Chen Y, Xu GZ, Ma R, et al. A study on the epidemic of pneumonia among children in Ningbo City, Zhejiang Province, 2009-2012[J]. Chin J Pre Med, 2014, 48(12):1053-1056. DOI: 10.3760/cma.j.issn.0253-9624.2014.12.007.
[22]	Khowaja AR, Mohiuddin S, Cohen AL, et al. Effectiveness of haemophilus influenzae type b conjugate vaccine on radiologically-confirmed pneumonia in young children in Pakistan[J]. J Pediatr, 2013, 163(1 Suppl):S79-S85. DOI: 10.1016/j.jpeds.2013.03.034.
[23]	Gessner BD, Sutanto A, Linehan M, et al. Incidences of vaccine-preventable Haemophilus influenzae type b pneumonia and meningitis in Indonesian children: hamlet-randomised vaccine-probe[J]. Lancet, 2005, 365(9453):43-52. DOI: 10.1016/s0140-6736(04)17664-2.
[24]	Flasche S, Takahashi K, Vu DT, et al. Early indication for a reduced burden of radiologically confirmed pneumonia in children following the introduction of routine vaccination against Haemophilus influenzae type b in Nha Trang, Vietnam[J]. Vaccine, 2014, 32(51):6963-6970. DOI: 10.1016/j.vaccine.2014.10.055.
[25]	胡俊, 王晓蕾, 艾涛, 等.下呼吸道感染住院患儿流感嗜血杆菌感染前瞻性多中心流行病学研究[J].中华儿科杂志, 2016, 54(2):119-125. DOI: 10.3760/cma.j.issn.0578-1310.2016.02.010. Hu J, Wang XL, Ai T, et al. Multicenter prospective epidemiology studies on Haemophilus influenzae infection among hospitalized children with lower respiratory tract infections[J]. Chin J Pediatr, 2016, 54(2):119-125. DOI: 10.3760/cma.j.issn.0578-1310.2016.02.010.
[26]	Slack MPE. The evidence for non-typeable Haemophilus influenzae as a causative agent of childhood pneumonia[J]. Pneumonia, 2017, 9(9):1-4. DOI: 10.1186/s41479-017-0033-2.