Carriage and its influencing factors of Staphylococcus aureus among kindergarten children

CHEN Min-qi; WANG Xu-lin; LI Wen-yu; FU Jin-jian; YE Xiao-hua

doi:10.16462/j.cnki.zhjbkz.2021.03.021

Volume 25 Issue 3

Mar. 2021

Turn off MathJax

Article Contents

Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(3): 363-367

CHEN Min-qi, WANG Xu-lin, LI Wen-yu, FU Jin-jian, YE Xiao-hua. Carriage and its influencing factors of Staphylococcus aureus among kindergarten children[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 363-367. doi: 10.16462/j.cnki.zhjbkz.2021.03.021

Citation:

CHEN Min-qi, WANG Xu-lin, LI Wen-yu, FU Jin-jian, YE Xiao-hua. Carriage and its influencing factors of Staphylococcus aureus among kindergarten children[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(3): 363-367. doi: 10.16462/j.cnki.zhjbkz.2021.03.021

Citation:

PDF( 1037 KB)

Carriage and its influencing factors of Staphylococcus aureus among kindergarten children

doi: 10.16462/j.cnki.zhjbkz.2021.03.021

1.
School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China
2.
Department of Prevention and Health Care, Liuzhou Maternity and Child Health Care Hospital, Liuzhou 545001, China

Funds:

National Natural Science Foundation of China 81973069

Guangdong Basic and Applied Basic Research Foundation 2019A1515010915

Liuzhou Science and Technology Bureau Project 2018BJ10504

More Information

Corresponding author: YE Xiao-hua, E-mail: smalltomato@163.com
Received Date: 2020-10-12
Rev Recd Date: 2021-01-11
Publish Date: 2021-03-10

Abstract

Abstract

Objective To master the carriage rate and its influencing factors of Staphylococcus aureus (S. aureus) in kindergarten children. Methods A multi-stage stratified cluster sampling method was used to sample 1 702 healthy children from six kindergartens in Liuzhou City. Nasal swabs were taken and tested for S. aureus. Chi-squared test was used to test carriage rates between groups, and logistic regression was used to analyze the effects of multiple influencing factors. Results The nasal carriage rate of S. aureus in children was 16.27%. Multivariate logistic regression analysis showed that age (OR=1.72 for children aged 4 years, OR=2.68 for children aged 5 years, OR=2.95 for children aged 6 years, and OR=4.58 for children aged 7 years), having history of antibiotic use (OR=1.44), and having history of skin and soft tissue infection (OR=1.34) were risk factors for S. aureus carriage, while the nasal carriage of Streptococcus pneumoniae (OR=0.17) was a protective factor. Conclusions Older age, history of antibiotic use and history of skin and soft tissue infection are important influencing factors for children S. aureus carriage.
- Children,
- Staphylococcus aureus,
- Influencing factors

FullText(HTML)

References(18)

References

[1]	Krismer B, Peschel A. Does Staphylococcus aureus nasal colonization involve biofilm formation?[J]. Future Microbiol, 2011, 6(5): 489-493. DOI: 10.2217/fmb.11.37.
[2]	von Eiff C, Becker K, Machka K, et al. Nasal carriage as a source of Staphylococcus aureus bacteremia[J]. N Engl J Med, 2001, 344(1): 11-16. DOI: 10.1056/NEJM200101043440102.
[3]	Davoodabadi F, Mobasherizadeh S, Mostafavizadeh K, et al. Nasal colonization in children with community acquired methicillin-resistant Staphylococcus aureus[J]. Adv Biomed Res, 2016, 5: 86. DOI: 10.4103/2277-9175.182217.
[4]	Ho PL, Chiu SS, Chan MY, et al. Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong[J]. J Infect, 2012, 64(5): 500-506. DOI: 10.1016/j.jinf.2012.02.018.
[5]	Peacock SJ, de Silva I, Lowy FD. What determines nasal carriage of Staphylococcus aureus?[J]. Trends Microbiol, 2001, 9(12): 605-610. DOI: 10.1016/s0966-842x(01)02254-5.
[6]	叶小华, 傅锦坚, 周俊立, 等. 儿童携带耐甲氧西林金黄色葡萄球菌及影响因素[J]. 中国妇幼保健, 2014, 29(9): 1359-1361. DOI: 10.7620/zgfybj.j.issn.1001-4411.2014.09.16. Ye XH, Fu JJ, Zhou JL, et al. Influencing factors of methicillin-resistant Staphylococcus aureus carried by children[J]. Matern Child health Care of China, 2014, 29(9): 1359-1361. DOI: 10.7620/zgfybj.j.issn.1001-4411.2014.09.16.
[7]	邓建军, 万朝敏, 母得志, 等. 在校健康儿童鼻前庭携带金黄色葡萄球菌检测及药物敏感分析[J]. 四川大学学报(医学版), 2012, 43(3): 391-394. DOI: 10.13464/j.scuxbyxb.2012.03.013. Deng JJ, Wan CM, Mu DZ, et al. Nasal carriage of communitv-acquired Staphylococcus aureus and drug sensitivity tests in healthy children in Chengdu[J]. J Sichuan Univ (Med Sci Ed), 2012, 43(3): 391-394. DOI: 10.13464/j.scuxbyxb.2012.03.013.
[8]	Chen CH, Kuo KC, Hwang KP, et al. Risk factors for and molecular characteristics of methicillin-resistant Staphylococcus aureus nasal colonization among healthy children in southern Taiwan, 2005-2010[J]. J Microbiol Immunol Infect, 2019, 52(6): 929-936. DOI: 10.1016/j.jmii.2018.09.003.
[9]	Lamaro-Cardoso J, de Lencastre H, Kipnis A, et al. Molecular epidemiology and risk factors for nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus in infants attending day care centers in Brazil[J]. J Clin Microbiol, 2009, 47(12): 3991-3997. DOI: 10.1128/JCM.01322-09.
[10]	Ciftci IH, Koken R, Bukulmez A, et al. Nasal carriage of Staphylococcus aureus in 4-6 age groups in healthy children in Afyonkarahisar, Turkey[J]. Acta Paediatr, 2007, 96(7): 1043-1046. DOI: 10.1111/j.1651-2227.2007.00315.x.
[11]	杨梅玲, 李晓红. 儿童社区获得性耐甲氧西林金葡菌感染的危险因素分析[J]. 山东医药, 2013, 53(32): 68-69. DOI:10.3969/j.Issn.1002-266X.2013.32.026. Yang ML, Li XH. Analysis of risk factors for community-acquired methicillin-resistant Staphylococcus aureus infection in children[J]. Shandong Med J, 2013, 53(32): 68-69. DOI: 10.3969/j.issn.1002-266X.2013.32.026.
[12]	Halablab MA, Hijazi SM, Fawzi MA, et al. Staphylococcus aureus nasal carriage rate and associated risk factors in individuals in the community[J]. Epidemiol Infect, 2010, 138(5): 702-706. DOI: 10.1017/S0950268809991233.
[13]	Fritz SA, Garbutt J, Elward A, et al. Prevalence of and risk factors for community-acquired methicillin-resistant and methicillin-sensitive Staphylococcus aureus colonization in children seen in a practice-based research network[J]. Pediatrics, 2008, 121(6): 1090-1098. DOI: 10.1542/peds.2007-2104.
[14]	Pan HH, Huang YC, Chen CJ, et al. Prevalence of and risk factors for nasal methicillin-resistant Staphylococcus aureus colonization among children in central Taiwan[J]. J Microbiol Immunol Infect, 2019, 52(1): 45-53. DOI: 10.1016/j.jmii.2016.08.020.
[15]	Regev-Yochay G, Trzcinski K, Thompson CM, et al. Interference between Streptococcus pneumoniae and Staphylococcus aureus: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae[J]. J Bacteriol, 2006, 188(13): 4996-5001. DOI: 10.1128/jb.00317-06.
[16]	Nelson AL, Ries J, Bagnoli F, et al. RrgA is a pilus-associated adhesin in Streptococcus pneumoniae[J]. Mol Microbiol, 2007, 66(2): 329-340. DOI: 10.1111/j.1365-2958.2007.05908.x.
[17]	Barocchi MA, Ries J, Zogaj X, et al. A pneumococcal pilus influences virulence and host inflammatory responses[J]. Proc Natl Acad Sci USA, 2006, 103(8): 2857-2862. DOI: 10.1073/pnas.0511017103.
[18]	Madhi SA, Adrian P, Kuwanda L, et al. Long-term effect of pneumococcal conjugate vaccine on nasopharyngeal colonization by Streptococcus pneumoniae-and associated interactions with Staphylococcus aureus and Haemophilus influenzae colonization-in HIV-infected and HIV-uninfected children[J]. J Infect Dis, 2007, 196(11): 1662-1666. DOI: 10.1086/522164.