Frailty subtypes among people living with HIV and HIV-negative individuals in Taizhou, Zhejiang: a cluster analysis

LI Jing; YUAN Shi-ying; CHEN Xiao-xiao; LIN Hai-jiang; HE Na; DING Ying-ying

doi:10.16462/j.cnki.zhjbkz.2021.06.015

Volume 25 Issue 6

Jul. 2021

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LI Jing, YUAN Shi-ying, CHEN Xiao-xiao, LIN Hai-jiang, HE Na, DING Ying-ying. Frailty subtypes among people living with HIV and HIV-negative individuals in Taizhou, Zhejiang: a cluster analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(6): 703-708. doi: 10.16462/j.cnki.zhjbkz.2021.06.015

Citation:

LI Jing, YUAN Shi-ying, CHEN Xiao-xiao, LIN Hai-jiang, HE Na, DING Ying-ying. Frailty subtypes among people living with HIV and HIV-negative individuals in Taizhou, Zhejiang: a cluster analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(6): 703-708. doi: 10.16462/j.cnki.zhjbkz.2021.06.015

Citation:

LI Jing, YUAN Shi-ying, CHEN Xiao-xiao, LIN Hai-jiang, HE Na, DING Ying-ying. Frailty subtypes among people living with HIV and HIV-negative individuals in Taizhou, Zhejiang: a cluster analysis[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(6): 703-708. doi: 10.16462/j.cnki.zhjbkz.2021.06.015

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Frailty subtypes among people living with HIV and HIV-negative individuals in Taizhou, Zhejiang: a cluster analysis

doi: 10.16462/j.cnki.zhjbkz.2021.06.015

1.
1Department of Epidemiology, School of Public Health, Fudan University, The Key Laboratory of Public Health Safety of Ministry of Education, Shanghai 200032, China
2.
Taizhou City Center for Disease Control and Prevention, Taizhou 318000, China

Funds:

National Natural Science Foundation of China 81872671

China National Science and Technology Major Projects on Infectious Diseases 2018ZX10721102-004

More Information

Corresponding author: DING Ying-ying, E-mail: dingyy@fudan.edu.cn
Received Date: 2020-08-24
Rev Recd Date: 2020-10-25
Publish Date: 2021-06-10

Abstract

Abstract

Objective To identify the frailty subtypes and investigate their differences in distribution and epidemiological characteristics between people living with HIV (PLWH) and HIV-negative individuals, to provide evidence for conducting intervention on frail PLWH. Methods PLWH and HIV-negative individuals who met the Fried's frailty phenotype criteria were selected from the baseline survey of the comparative HIV and aging research in Taizhou cohort (CHART) from February 2017 to January 2020. Latent cluster analysis was conducted to identify the frailty subtypes based on five Fried frailty components. Results Among 83 frail PLWH and 101 frail HIV-negative individuals included, three frailty clusters were identified. Cluster 1 was characterized by weakness with low physical activity, exhaustion and weak grip strength, which was defined as weakness group; cluster 2 was characterized by 5 poor items with slow walking pace as prominent feature, which was defined as slow walking pace group; cluster 3 was characterized by weight loss and mild weakness, which was defined as emaciation group. Proportion of frail PLWH was the highest in slow walking pace group (54.2%), but proportion of frail HIV-negative individuals was the highest in weakness group(35.6%). Frail PLWH in slow walking pace group were more likely to be current smokers compared with those in emaciation group(χ² =10.889, P=0.004). Frail PLWH in weakness group were more likely to be current smokers compared with those in emaciation group(χ² =7.909, P=0.019). Frail PLWH in emaciation group were more likely to be underweight compared to those in weakness group(χ² =9.309, P=0.009). Frail HIV-negative individuals in weakness group were more likely to be aged over 60 years old compared to those in emaciation group(χ² =10.502, P=0.001), but less likely to have sleep disorders than those in emaciation group(χ² =6.541, P=0.011). Frail HIV-negative individuals in slow walking pace group were more likely to be aged over 60 years old compared to those in emaciation group(χ² =6.232, P=0.013). Conclusions Distribution of frailty subtypes are different between frail PLWH and HIV-negative individuals. Frail PLWH have more frailty subtype characterized by 5 poor components with slow walking pace as the prominent feature. Screening and intervention should be actively carried out considering frailty subtypes and their characteristics in PLWH.
- AIDS,
- Frailty,
- Sleep disorders,
- Depressive symptoms,
- Comorbidity

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References(25)

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