The study on the relationship between herpes zoster and depression based on Health Big Data—Real world research examples

DING Xiong; JIANG Wei; JIANG Jing; HU Yue-hua; WU Ying; LI Yun; ZHAO Dan-dan; YIN Da-peng

doi:10.16462/j.cnki.zhjbkz.2021.06.019

Volume 25 Issue 6

Jul. 2021

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DING Xiong, JIANG Wei, JIANG Jing, HU Yue-hua, WU Ying, LI Yun, ZHAO Dan-dan, YIN Da-peng. The study on the relationship between herpes zoster and depression based on Health Big Data—Real world research examples[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(6): 730-733. doi: 10.16462/j.cnki.zhjbkz.2021.06.019

Citation:

DING Xiong, JIANG Wei, JIANG Jing, HU Yue-hua, WU Ying, LI Yun, ZHAO Dan-dan, YIN Da-peng. The study on the relationship between herpes zoster and depression based on Health Big Data—Real world research examples[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(6): 730-733. doi: 10.16462/j.cnki.zhjbkz.2021.06.019

Citation:

DING Xiong, JIANG Wei, JIANG Jing, HU Yue-hua, WU Ying, LI Yun, ZHAO Dan-dan, YIN Da-peng. The study on the relationship between herpes zoster and depression based on Health Big Data—Real world research examples[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(6): 730-733. doi: 10.16462/j.cnki.zhjbkz.2021.06.019

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The study on the relationship between herpes zoster and depression based on Health Big Data—Real world research examples

doi: 10.16462/j.cnki.zhjbkz.2021.06.019

1.
School of Public Health, North China University of Science and Technology, Tangshan 063210, China
2.
Yichang Center for Disease Control and Prevention, Yichang 443003, China
3.
Office of Epidemiology, Chinese Center for Disease Control and Prevention, Beijing 102206, China

DING Xiong and JIANG Wei contributed equally to this article

Funds:

2020 Beijing Natural Science Foundation L202008

Beihang University & Capital Medical University Advanced Innovation Center for Big Data-Based Precision Medicine Plan BHME-201801

Scientific Research Project of Chinese Center for Disease Control and Prevention 59911917

More Information

Corresponding author: HU Yue-hua, E-mail: huyueer@163.com; WU ying, E-mail: wyzhdd@sina.com
Received Date: 2020-08-04
Rev Recd Date: 2020-11-10
Publish Date: 2021-06-10

Abstract

Abstract

Objective The aim of our study was to explore the relationship between depression and the risk of herpes zoster in Yichang City. Methods With use of the Health Big Data of Yichang City, China, patients who were diagnosed with herpes zoster by clinicians between September 1, 2018 to September 30, 2019 were included. For each patient with herpes zoster, 4 matched controls were identified, matched for age (class interval: 10 years old) and sex. Controls took the index date of their matched case, and conditional Logistic regression analysis model was used to evaluate the relationship between depression and the risk of herpes zoster. Results In age was 56 (43, 67) years old, a total of 5 370 cases were included and 21 480 controls were matched. There were 2 533 males (47.17%) in the case group and 10 132 males (47.17%) in the control group. After adjusting for potential confounding factors, patients with depression had the 1.697 times risk of shingles as those without depression, the OR (odds ratio, OR) for case group was 1.697, (95% CI: 1.089-2.643, P=0.019), compared with matched controls. This relationship also observed in female (OR=1.983, 95% CI: 1.124-3.498, P=0.018), age under 50 years old (OR=2.213, 95% CI: 1.059-4.629, P=0.035) and older than 70 years old (OR=2.738, 95% CI: 1.264-5.929, P=0.011). Conclusion The recent study suggested that depression may be a risk factor for herpes zoster, especially in females, individuals under 50 years old and older than 70 years old.
- Herpes zoster,
- Depression,
- Big data

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References(13)

References

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