Advances in applications of polygenic risk score in precision prevention

WANG Tian-pei; JIN Guang-fu; HU Zhi-bin; SHEN Hong-bing

doi:10.16462/j.cnki.zhjbkz.2021.09.001

Volume 25 Issue 9

Oct. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(9): 993-997

WANG Tian-pei, JIN Guang-fu, HU Zhi-bin, SHEN Hong-bing. Advances in applications of polygenic risk score in precision prevention[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 993-997. doi: 10.16462/j.cnki.zhjbkz.2021.09.001

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WANG Tian-pei, JIN Guang-fu, HU Zhi-bin, SHEN Hong-bing. Advances in applications of polygenic risk score in precision prevention[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 993-997. doi: 10.16462/j.cnki.zhjbkz.2021.09.001

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Advances in applications of polygenic risk score in precision prevention

doi: 10.16462/j.cnki.zhjbkz.2021.09.001

WANG Tian-pei^{1, 2},
JIN Guang-fu^{1, 2
,
,},
HU Zhi-bin^{1, 2},
SHEN Hong-bing¹

1.
Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China
2.
School of Gusu, Nanjing Medical University, Suzhou 215008, China

Funds:

National Natural Science Foundation of China 81872702

More Information

Corresponding author: JIN Guang-fu, E-mail: guangfujin@njmu.edu.cn
Received Date: 2021-08-10
Rev Recd Date: 2021-08-23

Available Online: 2021-10-23

Publish Date: 2021-09-10

Abstract

Abstract

Genome-wide association studies have successfully identified numerous genetic loci for complex diseases. Polygenic risk score combining multiple loci together has been proved to effectively measure genetic risk of complex diseases, which poses opportunities for risk stratification and potential precision medicine application. This paper briefly reviews the recent progress in the development and evaluation of polygenic risk score, and summarizes its application in precision prevention.
- Polygenic risk score,
- Genome-wide association study,
- Precision prevention

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References(35)

References

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