Association of blood lipid and genetic factor with cancer risk in men

HU Bei-ping; WANG Tian-pei; ZHU Meng; YAN Cai-wang; JIN Guang-fu

doi:10.16462/j.cnki.zhjbkz.2021.09.003

Volume 25 Issue 9

Oct. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(9): 1003-1007

HU Bei-ping, WANG Tian-pei, ZHU Meng, YAN Cai-wang, JIN Guang-fu. Association of blood lipid and genetic factor with cancer risk in men[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1003-1007. doi: 10.16462/j.cnki.zhjbkz.2021.09.003

Citation:

HU Bei-ping, WANG Tian-pei, ZHU Meng, YAN Cai-wang, JIN Guang-fu. Association of blood lipid and genetic factor with cancer risk in men[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1003-1007. doi: 10.16462/j.cnki.zhjbkz.2021.09.003

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Association of blood lipid and genetic factor with cancer risk in men

doi: 10.16462/j.cnki.zhjbkz.2021.09.003

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Funds:

National Natural Science Foundation of China 81872702

National Natural Science Foundation of China 82003534

National Natural Science Foundation of Jiangsu Province BK20200674

More Information

Corresponding author: JIN Guang-fu, E-mail: guangfujin@njmu.edu.cn
Received Date: 2021-08-13
Rev Recd Date: 2021-08-25

Available Online: 2021-10-23

Publish Date: 2021-09-10

Abstract

Abstract

Objective To investigate the potential roles of blood lipid levels and genetic factors in cancer development in men. Methods Male participants in the UK Biobank (UKB) were stratified into low, intermediate and high genetic risk groups. The number of abnormal lipid levels was used to divide study subjects into three categories. The association between abnormal levels of blood lipid and the risk of cancer incidence under different genetic risks were analyzed. Results A total of 178 171 men were included in the study, of whom 11 824 (6.64%) developed new cancer cases within the follow-up period. After adjustment for confounders including age, smoking, alcohol consumption, and fasting plasma glucose, abnormal lipid score was associated with the risk of cancer (all P < 0.001). Men with high genetic risk and high lipid abnormal score had 2.290 fold higher (95% CI: 2.039-2.571, P < 0.001) overall cancer risk than those with low genetic risk and low lipid abnormal score. Conclusion Abnormal levels of blood lipid may increase the risk of cancer across different genetic risk groups in men.
- Blood lipids,
- Polygenic risk score,
- Cancer risk,
- Association

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References(19)

References

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