The association between hypertriglyceridemia-waist and hyperuricemia

ZHANG Kai-xuan; LIN Hai; LUO Dan; HU Kuan; ZOU Pin-ang; LUO Fang; CHEN Yue; PENG Wen-hui; WANG Bao-guo

doi:10.16462/j.cnki.zhjbkz.2021.09.020

Volume 25 Issue 9

Oct. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(9): 1107-1111

ZHANG Kai-xuan, LIN Hai, LUO Dan, HU Kuan, ZOU Pin-ang, LUO Fang, CHEN Yue, PENG Wen-hui, WANG Bao-guo. The association between hypertriglyceridemia-waist and hyperuricemia[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1107-1111. doi: 10.16462/j.cnki.zhjbkz.2021.09.020

Citation:

ZHANG Kai-xuan, LIN Hai, LUO Dan, HU Kuan, ZOU Pin-ang, LUO Fang, CHEN Yue, PENG Wen-hui, WANG Bao-guo. The association between hypertriglyceridemia-waist and hyperuricemia[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1107-1111. doi: 10.16462/j.cnki.zhjbkz.2021.09.020

Citation:

ZHANG Kai-xuan, LIN Hai, LUO Dan, HU Kuan, ZOU Pin-ang, LUO Fang, CHEN Yue, PENG Wen-hui, WANG Bao-guo. The association between hypertriglyceridemia-waist and hyperuricemia[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1107-1111. doi: 10.16462/j.cnki.zhjbkz.2021.09.020

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The association between hypertriglyceridemia-waist and hyperuricemia

doi: 10.16462/j.cnki.zhjbkz.2021.09.020

1.
Department of Epidemiology, School of Public Health, Guangdong Pharmaceutical University, Guangzhou 510310, China
2.
Zhongshan Center for Disease Control and Prevention Institute of Chronic Noncommunicable Diseases, Zhongshan 528400, China

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Corresponding author: WANG Bao-guo, E-mail: gdwangbaoguo@163.com
Received Date: 2021-01-26
Rev Recd Date: 2021-03-16

Available Online: 2021-10-23

Publish Date: 2021-09-10

Abstract

Abstract

Objective To study the relationship between hypertriglyceridemia-waist (HTGW) phenotype and high uric acidemia (HUA) and provide a basis for early identification of high-risk individuals of HUA. Methods Adults from 24 townships in Zhongshan City were selected by multi-stage random sampling method to conduct on-site questionnaires, physical examinations and biochemical index detection. The relationship between HTGW phenotype and HUA was analyzed using Logistic regression model, Goodman-Kruskal method and multivariate linear stepwise regression. Results A total of 7 173 subjects were included. The detectable rate was 15.2% for the HTGW phenotype population and 2 332 for HUA patients, with a detectable rate of 32.5%. The multi-factor Logistic regression analysis showed that the HTGW phenotype was an important risk factor for HUA (OR=2.689, 95% CI: 2.249-3.215, P <0.001). The results of the Goodman-Kruskal correlation analysis and Multiple linear regression modol showed that there was a significant positive correlation between the HTGW phenotype and HUA (P < 0.001). Conclusions HTGW phenotype is an important risk factor of HUA. In daily prevention and treatment of HUA, we should focus on monitoring people with HTGW phenotype.
- High uric acidemia,
- Serum uric acid,
- Biomarker,
- Hypertriglyceridemia-waist

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References(21)

References

[1]	王雪莹, 李楠, 郭佳桐, 等. 基于分类树模型对高尿酸血症的影响因素分析[J]. 中华疾病控制杂志, 2019, 23(11): 1364-1369. DOI: 10.16462/j.cnki.zhjbkz.2019.11.013. Wang XY, Li N, Guo JT, et al. Analysis on the associated factors of hyperuricemia: based on classification tree model[J]. Chin J Dis Control Prev, 2019, 23(11): 1364-1369. DOI: 10.16462/j.cnki.zhjbkz.2019.11.013.
[2]	Joo HJ, Kim GR, Choi DW, et al. Uric acid level and kidney function: a cross-sectional study of the Korean national health and nutrition examination survey (2016-2017)[J]. Sci Rep, 2020, 10(1): 21672. DOI: 10.1038/s41598-020-77702-x.
[3]	Wei CY, Sun CC, Wei JC, et al. Association between hyperuricemia and metabolic syndrome: an epidemiological study of a labor force population in Taiwan[J]. Biomed Res Int, 2015, 2015: 369179. DOI: 10.1155/2015/369179.
[4]	Yu W, Cheng JD. Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective[J]. Front Pharmacol, 2020, 11: 582680. DOI: 10.3389/fphar.2020.582680.
[5]	Lemieux I, Pascot A, Couillard C, et al. Hypertriglyceridemic waist: a marker of the atherogenic metabolic triad (hyperinsulinemia; hyperapolipoprotein B; small, dense LDL) in men?[J]. Circulation, 2000, 102(2): 179-184. DOI: 10.1161/01.cir.102.2.179.
[6]	Ma CM, Wang R, Liu XL, et al. The Relationship between Hypertriglyceridemic Waist Phenotype and Early Diabetic Nephropathy in Type 2 Diabetes[J]. Cardiorenal Med, 2017, 7(4): 295-300. DOI: 10.1159/000477828.
[7]	Qiu Y, Zhao Q, Wang N, et al. Association of hypertriglyceridemic waist phenotype with renal function impairment: a cross-sectional study in a population of Chinese adults[J]. Nutr Metab(Lond), 2020, 17: 63. DOI: 10.1186/s12986-020-00483-7.
[8]	LeBlanc S, Coulombe F, Bertrand OF, et al. Hypertriglyceridemic waist: a simple marker of high-risk atherosclerosis features associated with excess visceral adiposity/ectopic fat[J]. J Am Heart Assoc, 2018, 7(8): 1-15. DOI: 10.1161/JAHA.117.008139.
[9]	中国高血压防治指南修订委员会, 高血压联盟(中国), 中华医学会心血管病学分会, 等. 中国高血压防治指南(2018年修订版)[J]. 中国心血管杂志, 2019, 24(1): 24-56. DOI: 10.3969/j.issn.1007-5410.2019.01.002. Writing Group of 2018 Chinese Guidelines for the Management of Hypertension, Chinese Hypertension League, Chinese Society of Cardiology, et al. 2018 Chinese guidelines for the management of hypertension[J]. Chin J Cardiovasc Med, 2019, 24(1): 24-56. DOI: 10.3969/j.issn.1007-5410.2019.01.002.
[10]	中国肥胖问题工作组. 中国成人超重与肥胖症预防与控制指南(节录)[J]. 营养学报, 2004, 26(1): 1-4. DOI: 10.3321/j.issn:0512-7955.2004.01.001. Working Group on Obesity in China. Guidelines for prevention and control of overweight and obesity in Chinese adults[J]. Acta Nutr Sin, 2004, 26(1): 1-4. DOI: 10.3321/j.issn:0512-7955.2004.01.001.
[11]	李林, 朱小霞, 戴宇翔, 等. 中国高尿酸血症相关疾病诊疗多学科专家共识[J]. 中华内科杂志, 2017, 56(3): 235-248. DOI: 10.3760/cma.j.issn.0578-1426.2017.03.021. Li L, Zhu XX, Dai YX, et al. Chinese multi-disciplinary consensus on the diagnosis and treatment of hyperuricemia and its related diseases[J]. Chin J Intern Med, 2017, 56(3): 235-248. DOI: 10.3760/cma.j.issn.0578-1426.2017.03.021.
[12]	饶媛, 刘宏艺, 梁结玲, 等. 东莞市茶山镇成年人血脂异常与高尿酸血症的关系[J]. 新医学, 2020, 51(9): 718-723. DOI: 10.3969/j.issn.0253-9802.2020.09.016. Rao Y, Liu HY, Liang JL, et al, Association between hyperuricemia and dyslipidemia in Chinese adults from Chashan, Dongguan[J]. J New Med, 2020, 51(9): 718-723. DOI: 10.3969/j.issn.0253-9802.2020.09.016.
[13]	中华医学会内分泌学分会. 中国高尿酸血症与痛风诊疗指南(2019)[J]. 中华内分泌代谢杂志, 2020, 36(1): 1-13. DOI: 10.3760/cma.j.issn.1000-6699.2020.01.001. Chinese Society of Endocrinology, Chinese Medical Association. Guidelines for the diagnosis and treatment of hyperuricemia and gout in China(2019)[J]. Chin J Endocrinol Metab, 2020, 36(1): 1-13. DOI: 10.3760/cma.j.issn.1000-6699.2020.01.001.
[14]	张明峰, 郭惠芳, 高丽霞. 高尿酸血症对代谢综合征和心血管病的影响与防治[J]. 临床荟萃, 2016, 31(5): 496-500. DOI: 10.3969/j.issn.1004-583X.2016.05.007. Zhang MF, Guo HF, Gao LX. Pay attention to the influence and prevention strategy of hyperuricemia on metabolic syndrome and cardiovascular disease[J]. Clin Focus, 2016, 31(5): 496-500. DOI: 10.3969/j.issn.1004-583X.2016.05.007.
[15]	Chen S, Guo XF, Dong SY, et al. Association between the hypertriglyceridemic waist phenotype and hyperuricemia: a cross-sectional study[J]. Clin Rheumatol, 2017, 36(5): 1111-1119. DOI: 1111-1119.10.1007/s10067-017-3559-z.
[16]	Sam S, Haffner S, Davidson MH, et al. Hypertriglyceridemic waist phenotype predicts increased visceral fat in subjects with type 2 diabetes[J]. Diabetes Care, 2009, 32(10): 1916-1920. DOI: 10.2337/dc09-0412.
[17]	Fabregat I, Revilla E, Machado A. Short-term control of the pentose phosphate cycle by insulin could be modulated by the NADPH/NADP ratio in rat adipocytes and hepatocytes[J]. Biochem Biophys Res Commun, 1987, 146(2): 920-925. DOI: 10.1016/0006-291X(87)90618-8.
[18]	Rospleszcz S, Dermyshi D, Müller-Peltzer K, et al. Association of serum uric acid with visceral, subcutaneous and hepatic fat quantified by magnetic resonance imaging[J]. Sci Rep, 2020, 10(1): 442. DOI: 10.1038/s41598-020-57459-z.
[19]	Yamada A, Sato KK, Kinuhata S, et al. Association of visceral fat and liver fat with hyperuricemia[J]. Arthritis Care Res(Hoboken), 2016, 68(4): 553-561. DOI: 10.1002/acr.22729.
[20]	Björntorp P. "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes[J]. Arteriosclerosis, 1990, 10(4): 493-496. DOI: 10.1161/01.ATV.10.4.493.
[21]	Ma WY, Cui CM, Feng S, et al. Serum uric acid and triglycerides in Chinese patients with newly diagnosed moyamoya disease: a cross-sectional study[J]. Biomed Res Int, 2019, 2019: 9792412. DOI: 10.1155/2019/9792412.