Clinical epidemiological study on the association between neutrophil extracellular traps and acute myocardial infarction among coronary atherosclerotic heart disease

SHUAI Zi-qiang; ZHANG Cheng-xin; AN Cheng; GE Sheng-lin

doi:10.16462/j.cnki.zhjbkz.2021.09.021

Volume 25 Issue 9

Oct. 2021

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SHUAI Zi-qiang, ZHANG Cheng-xin, AN Cheng, GE Sheng-lin. Clinical epidemiological study on the association between neutrophil extracellular traps and acute myocardial infarction among coronary atherosclerotic heart disease[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1112-1116. doi: 10.16462/j.cnki.zhjbkz.2021.09.021

Citation:

SHUAI Zi-qiang, ZHANG Cheng-xin, AN Cheng, GE Sheng-lin. Clinical epidemiological study on the association between neutrophil extracellular traps and acute myocardial infarction among coronary atherosclerotic heart disease[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1112-1116. doi: 10.16462/j.cnki.zhjbkz.2021.09.021

Citation:

SHUAI Zi-qiang, ZHANG Cheng-xin, AN Cheng, GE Sheng-lin. Clinical epidemiological study on the association between neutrophil extracellular traps and acute myocardial infarction among coronary atherosclerotic heart disease[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(9): 1112-1116. doi: 10.16462/j.cnki.zhjbkz.2021.09.021

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Clinical epidemiological study on the association between neutrophil extracellular traps and acute myocardial infarction among coronary atherosclerotic heart disease

doi: 10.16462/j.cnki.zhjbkz.2021.09.021

Department of Cardiovascular Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

Funds:

Natural Foundation of Anhui Province 1808085MH279

More Information

Corresponding author: GE Sheng-lin, E-mail: geshenglin@ahmu.edu.cn
Received Date: 2021-07-04
Rev Recd Date: 2021-08-09

Available Online: 2021-10-23

Publish Date: 2021-09-10

Abstract

Abstract

Objective To investigate the change and its roles of neutrophil extracellular traps (NETs) in peripheral blood from patients with coronary atherosclerotic heart disease (CAHD) during their acute myocardial infarction (AMI) and post operation of coronary artery bypass graft (CABG), and to proride effective prevention and control of CAHD and AMI. Methods A total of 52 patients with AMI and 52 healthy controls (HCs) were involved in this study. The levels of NETs, fragment a of the factor B (Ba), fragment a of the 5th complement (C5a) and myeloperoxidase (MPO) in peripheral blood were detected by enzyme linked immunosorbent assay (ELISA) at the onset of AMI [pre-treatment (PRT) group], post-operative treatment group (POT group) and in HC group. Their differences between the groups were detected by t test while the relationships between the parameters in PRT group were tested by Pearson correlation analysis. Results All the parameters from PRT and POT group were higher than those in the HC group, respectively. The levels of cardiac troponin I (cTnI), NETs, Ba, C5a and MPO in PRT group were higher than those in POT group [(0.279±0.132) ng/ml vs.(0.016±0.008) ng/ml, P < 0.001; OD value: (0.466±0.143) vs. (0.378±0.151), P=0.002; (72.812±30.144) pg/ml vs. (60.491±28.323) pg/ml, P=0.001; (327.112±203.228) ng/ml vs. (260.411±135.984) ng/ml, P=0.025; (75.782±33.596) ng/ml vs. (58.462±29.647) ng/ml, P=0.008, respectively]. In PRT group, NETs was positively correlated with Ba, C5a and MPO (r=0.394, P=0.001; r=0.324, P=0.030 and r=0.406, P < 0.001), respectively, and Ba had positive correlation with C5a (r=0.436, P < 0.001) while cTnI was only correlated with NETs (r=0.352, P=0.008). The cTnI level, though recovered to normal range in POT group, was still higher than that in HC group [(0.016±0.008) pg/ml vs. (0.012±0.007) pg/ml, P=0.016]. Conclusions The persistent high level of NETs and its related high activity of complement alternative pathway in CAHD during the onset of AMI and post-treatment of CABG might contribute to the progression of the disease and the recurrence of myocardial infarction. Intervention on the formation of NETs might be one of the potential pathways to prevent the progression of CHAD and the occurrence of AMI.
- Coronary atherosclerotic heart disease,
- Acute myocardial infarction,
- Coronary artery bypass graft,
- Neutrophil extracellular traps,
- Pathogenesis

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References(27)

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