A study of the polymorphisms of <i>XPC</i> rs2279017 and susceptibility of esophageal cancer

DUAN Pei-fen; ZHOU Yan; FENG Xiang-xian

doi:10.16462/j.cnki.zhjbkz.2021.10.014

Volume 25 Issue 10

Nov. 2021

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DUAN Pei-fen, ZHOU Yan, FENG Xiang-xian. A study of the polymorphisms of XPC rs2279017 and susceptibility of esophageal cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(10): 1194-1197. doi: 10.16462/j.cnki.zhjbkz.2021.10.014

Citation:

DUAN Pei-fen, ZHOU Yan, FENG Xiang-xian. A study of the polymorphisms of XPC rs2279017 and susceptibility of esophageal cancer[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(10): 1194-1197. doi: 10.16462/j.cnki.zhjbkz.2021.10.014

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A study of the polymorphisms of XPC rs2279017 and susceptibility of esophageal cancer

doi: 10.16462/j.cnki.zhjbkz.2021.10.014

1.
Department of Preventive Medicine, Changzhi Medical College, Changzhi 046000, China
2.
Jincheng General Hospital, Jincheng 048006, China

Funds:

Program for the Philosophy and Social Sciences Research of Higher Learning Institutions of Shanxi 2019W099

Soft Science Research Program of Shanxi 2019041048-4

More Information

Corresponding author: FENG Xiang-xian, E-mail: xfeng66@163.com
Received Date: 2021-03-01
Rev Recd Date: 2021-05-05

Available Online: 2021-11-17

Publish Date: 2021-10-10

Abstract

Abstract

Objective To investigate the relationship between the polymorphisms of xeroderma pigmentosum group C (XPC) rs2279017 and the susceptibility of esophageal cancer in Changzhi area and its interaction with major risk factors. Methods In this study, 150 cases of esophageal cancer and 176 cases of control were selected to participate in the questionnaire survey, and the group case-control study was conducted. Then, the genotype of XPC rs2279017 was detected by quantitatire real-time PCR. The results were analyzed by SPSS 20.0. Results In the control group, the frequencies of XPC genotype (GG, GT, TT) were 48.86%, 42.05%, 9.09%, respectively. Among the esophageal cancer group, the rates were 29.33%, 46.00% and 24.67%, respectively, and the difference was statistically significant (χ² =20.12, P < 0.001). The risk of esophageal cancer with allele T was 2.11 times that with allele G (OR=2.11, 95% CI: 1.53-2.92, P < 0.001). In addition, interaction analysis showed that XPC mutant T had a synergistic effect on alcohol consumption (RERI=1.26, S=1.91, API=0.35). Conclusions Polymorphism of XPC rs2279017 may be related to the occurrence of esophageal cancer in Changzhi City.
- Esophageal cancer,
- Xeroderma pigmentosum group C,
- Genetic polymorphisms,
- Interaction

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References(12)

References

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