Interaction of overweight/obesity and hyperhomocysteinemia on risk of hypertension

XIE Ming; ZENG Yuan; YUAN Shu-qian; LIU Yin-yue; ZHOU Jun-hua; HE Quan-yuan; HONG Xiu-qin; YANG Yi-de

doi:10.16462/j.cnki.zhjbkz.2021.11.006

Volume 25 Issue 11

Nov. 2021

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Article Navigation > CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION > 2021 > 25(11): 1269-1275

XIE Ming, ZENG Yuan, YUAN Shu-qian, LIU Yin-yue, ZHOU Jun-hua, HE Quan-yuan, HONG Xiu-qin, YANG Yi-de. Interaction of overweight/obesity and hyperhomocysteinemia on risk of hypertension[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(11): 1269-1275. doi: 10.16462/j.cnki.zhjbkz.2021.11.006

Citation:

XIE Ming, ZENG Yuan, YUAN Shu-qian, LIU Yin-yue, ZHOU Jun-hua, HE Quan-yuan, HONG Xiu-qin, YANG Yi-de. Interaction of overweight/obesity and hyperhomocysteinemia on risk of hypertension[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(11): 1269-1275. doi: 10.16462/j.cnki.zhjbkz.2021.11.006

Citation:

XIE Ming, ZENG Yuan, YUAN Shu-qian, LIU Yin-yue, ZHOU Jun-hua, HE Quan-yuan, HONG Xiu-qin, YANG Yi-de. Interaction of overweight/obesity and hyperhomocysteinemia on risk of hypertension[J]. CHINESE JOURNAL OF DISEASE CONTROL & PREVENTION, 2021, 25(11): 1269-1275. doi: 10.16462/j.cnki.zhjbkz.2021.11.006

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Interaction of overweight/obesity and hyperhomocysteinemia on risk of hypertension

doi: 10.16462/j.cnki.zhjbkz.2021.11.006

1.
Department of Child and Adolescent Health, School of Medicine, Hunan Normal University, Changsha 410013, China
2.
Key Laboratory of Molecular Epidemiology of Hunan Province, Hunan Normal University, Changsha 410005, China

Funds:

National Natural Science Foundation of China 81773530

National Natural Science Foundation of China 81903336

Natural Science Foundation of Hunan Province 2019JJ50376

Hunan Province college students research learning and innovative experiment project S202110542057

More Information

Corresponding author: HONG Xiu-qin, E-mail: hldhld@126.com; YANG Yi-de, E-mail: yangyide2007@126.com
Received Date: 2020-12-16
Rev Recd Date: 2021-02-27

Available Online: 2021-12-04

Publish Date: 2021-11-10

Abstract

Abstract

Objective To investigate the interaction between overweight/obesity and hyperhomocysteinemia (HHcy) on the risk of hypertension. Methods Six districts in Hunan Province (Changsha, Zhuzhou, Yongzhou, Hengyang, Yueyang, and Xiangxi) were selected from June 2013 to May 2014 by the stratified cluster sampling method. Two urban and two rural communities were randomly selected in each district. A total of 5 258 residents aged 30 or above and living in the district for at least 5 years were invited to participate in the present study. Physical examination, questionnaire survey and laboratory measurements were conducted for participants. Logistic regression model was used to analyze the association between overweight/obesity or HHcy and the risk of hypertension, and the additive and multiplicative interaction were further analyzed. Results Among 4 012 subjects with complete data, 1 538 were categorized with hypertension (38.3%); 39.3% participants were considered to be overweight/obese and 35.1% participants with HHcy. After adjustment with covariates such as gender, age, marital status, educational level, smoking, alcohol drinking, diet behavior and physical activity, multivariate unconditional Logistic regression analysis showed that the risk of hypertension in overweight/obese participants was 2.801 times (95% CI: 2.407-3.261) of that in participants without overweight/obesity, and the risk of hypertension in HHcy participant was 3.488 times (95% CI: 3.000-4.055) of that in normal Hcy participants. The risk of hypertension in participants with both overweight and HHcy was 10.205 times (95% CI: 8.120-12.826) of that in non-overweight/obese participants with normal Hcy. With further interaction analysis, we found that the Relative Excess Risk of Interaction, Attributable Proportion of Interaction and Interaction Index S of coexisting of overweight/obesity and HHcy were 5.218 (95% CI: 3.213-7.222), 0.527 (95% CI: 0.420-0.634) and 2.415 (95% CI: 1.848-3.156), respectively, which means that overweight/obesity and HHcy have an additive interaction effect on hypertension. There was no significant multiplicative interaction between overweight/obesity and HHcy (OR=1.246, 95% CI: 0.920-1.688). Conclusions Overweight/obesity and HHcy are both associated higher risk of hypertension. In addition, there is an interaction between overweight/obesity and HHcy associated with significantly elavated risk of hypertension.
- Hypertension,
- Overweight,
- Obesity,
- Hyperhomocysteinemia,
- Interaction

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References(29)

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